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1446. Application of Machine Learning Models to Biomedical and Information System Signals From Critically Ill Adults.
作者: Craig M Lilly.;David Kirk.;Itai M Pessach.;Gurudev Lotun.;Ofer Chen.;Ari Lipsky.;Iris Lieder.;Gershon Celniker.;Eric W Cucchi.;James M Blum.
来源: Chest. 2024年165卷5期1139-1148页
Machine learning (ML)-derived notifications for impending episodes of hemodynamic instability and respiratory failure events are interesting because they can alert physicians in time to intervene before these complications occur.
1447. Clinical Response and Remission in Patients With Severe Asthma Treated With Biologic Therapies.
作者: Susanne Hansen.;Marianne Baastrup Søndergaard.;Anna von Bülow.;Anne-Sofie Bjerrum.;Johannes Schmid.;Linda M Rasmussen.;Claus R Johnsen.;Truls Ingebrigtsen.;Kjell Erik Julius Håkansson.;Sofie Lock Johansson.;Maria Bisgaard.;Karin Dahl Assing.;Ole Hilberg.;Charlotte Ulrik.;Celeste Porsbjerg.
来源: Chest. 2024年165卷2期253-266页
The development of novel targeted biologic therapies for severe asthma has provided an opportunity to consider remission as a new treatment goal.
1448. Longitudinal Effects of Elexacaftor/Tezacaftor/Ivacaftor: Multidimensional Assessment of Neuropsychological Side Effects and Physical and Mental Health Outcomes in Adolescents and Adults.
作者: Sonia Graziano.;Francesca Boldrini.;Gaia Romana Pellicano.;Francesco Milo.;Fabio Majo.;Luca Cristiani.;Enza Montemitro.;Federico Alghisi.;Sergio Bella.;Renato Cutrera.;Alessandro Giovanni Fiocchi.;Alexandra Quittner.;Paola Tabarini.
来源: Chest. 2024年165卷4期800-809页
Italy initiated elexacaftor/tezacaftor/ivacaftor (ETI) for people with cystic fibrosis (pwCF) in July 2021. It has led to dramatic improvements in lung function, BMI, sweat chloride, and respiratory symptoms. However, few data are available on side effects or effects on a broad range of outcomes.
1449. Stage at Diagnosis Following Delay to Interval Scans for Indeterminate Nodules in Lung Cancer Screening: An Observational Study Examining the Outcomes of CHEST Expert Panel Recommendations.
作者: Andrew W Creamer.;Carolyn Horst.;Jennifer L Dickson.;Sophie Tisi.;Helen Hall.;Priyam Verghese.;Ruth Prendecki.;Amyn Bhamani.;Chuen R Khaw.;John McCabe.;Tanita Limani.;Kylie Gyertson.;Anne-Marie Hacker.;J Teague.;L Farrelly.;Shrinkhala Dawadi.;Allan Hackshaw.;Anand Devaraj.;Arjun Nair.;Sam M Janes.; .
来源: Chest. 2024年165卷4期1020-1024页 1450. Epigenetic Fingerprint of the SARS-CoV-2 Infection in the Lung of Lethal COVID-19.
作者: Aleix Noguera-Castells.;Jerónimo Parra.;Veronica Davalos.;Carlos A García-Prieto.;Yoana Veselinova.;Belén Pérez-Miés.;Tamara Caniego-Casas.;José Palacios.;Xavier Saenz-Sardà.;Elisabet Englund.;Eva Musulen.;Manel Esteller.
来源: Chest. 2024年165卷4期820-824页 1451. Management of Critically Ill Patients Receiving Medications for Opioid Use Disorder.
Critical care clinicians are likely to see an increasing number of patients admitted to the ICU who are receiving US Food and Drug Administration-approved medications for opioid use disorder (MOUDs) given the well-documented benefits of these agents. Oral methadone, multiple formulations of buprenorphine, and extended-release naltrexone are the three types of MOUD most likely to be encountered by ICU clinicians; however, these drugs vary with respect to formulations, pharmacokinetics, and adverse effects.
1452. Access to Lung Cancer Screening Among American Indian and Alaska Native Adults: A Qualitative Study.
作者: Allison C Welch.;Sara M London.;Candice L Wilshire.;Christopher R Gilbert.;Dedra Buchwald.;Gary Ferguson.;Cole Allick.;Jed A Gorden.
来源: Chest. 2024年165卷3期716-724页
Lung cancer is the leading cause of cancer mortality among American Indian and Alaska Native populations. American Indian and Alaska Native people use commercial tobacco products at higher rates compared with all other races and ethnicities. Moreover, they show lower adherence to cancer screening guidelines.
1453. Use and Outcomes of Peripheral Vasopressors in Early Sepsis-Induced Hypotension Across Michigan Hospitals: A Retrospective Cohort Study.
作者: Elizabeth S Munroe.;Megan E Heath.;Mousab Eteer.;Hayley B Gershengorn.;Jennifer K Horowitz.;Jessica Jones.;Scott Kaatz.;Maximiliano Tamae Kakazu.;Elizabeth McLaughlin.;Scott A Flanders.;Hallie C Prescott.
来源: Chest. 2024年165卷4期847-857页
Vasopressors traditionally are administered via central access, but newer data suggest that peripheral administration may be safe and may avoid delays and complications associated with central line placement.
1454. Ozanimod Therapy in Patients With COVID-19 Requiring Oxygen Support: A Randomized Open-Label Pilot Trial.
作者: François Lellouche.;Pascale Blais-Lecours.;François Maltais.;Jean-François Sarrazin.;Philippe Rola.;Tuyen Nguyen.;Nathalie Châteauvert.;David Marsolais.
来源: Chest. 2024年165卷4期810-819页
Sphingosine-1-phosphate receptor ligands (SRLs) dampen immunopathologic damages in models of viral pneumonia.
1455. Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest: A Retrospective Multicenter Cohort Study.
作者: Toru Takiguchi.;Naoki Tominaga.;Takuro Hamaguchi.;Tomohisa Seki.;Jun Nakata.;Takeshi Yamamoto.;Takashi Tagami.;Akihiko Inoue.;Toru Hifumi.;Tetsuya Sakamoto.;Yasuhiro Kuroda.;Shoji Yokobori.; .
来源: Chest. 2024年165卷4期858-869页
A better understanding of the relative contributions of various factors to patient outcomes is essential for optimal patient selection for extracorporeal CPR (ECPR) therapy for patients with out-of-hospital cardiac arrest (OHCA). However, evidence on the prognostic comparison based on the etiologies of cardiac arrest is limited.
1456. High-Resolution CT Scan Fibrotic Patterns in Stage IV Pulmonary Sarcoidosis: Impact on Pulmonary Function and Survival.
作者: Ogugua Ndili Obi.;Shehabaldin Alqalyoobi.;Veeranna Maddipati.;Elyse E Lower.;Robert P Baughman.
来源: Chest. 2024年165卷4期892-907页
Different patterns of fibrosis on high-resolution CT scans (HRCT) have been associated with reduced survival in some interstitial lung diseases. Nothing is known about HRCT scan patterns and survival in sarcoidosis.
1457. Exploring the Association of Male Sex With Adverse Outcomes in Severe Bronchopulmonary Dysplasia: A Retrospective, Multicenter Cohort Study.
作者: J D Hammond.;Matthew J Kielt.;Sara Conroy.;Krithika Lingappan.;Eric D Austin.;Laurie C Eldredge.;William E Truog.;Steven H Abman.;Leif D Nelin.;Milenka Cuevas Guaman.
来源: Chest. 2024年165卷3期610-620页
Bronchopulmonary dysplasia (BPD) is a significant contributor to morbidity and death in infants who are born premature. Male sex is an independent risk factor for the development of BPD. However, whether male sex is associated with adverse outcomes that occur after formal diagnosis of severe BPD prior to hospital discharge remains unclear.
1458. Associations of Plasma Omega-3 Fatty Acids With Progression and Survival in Pulmonary Fibrosis.
作者: John S Kim.;Shwu-Fan Ma.;Jennie Z Ma.;Yong Huang.;Catherine A Bonham.;Justin M Oldham.;Ayodeji Adegunsoye.;Mary E Strek.;Kevin R Flaherty.;Emma Strickland.;Inemesit Udofia.;Joshua J Mooney.;Shrestha Ghosh.;Krishnarao Maddipati.;Imre Noth.
来源: Chest. 2024年165卷3期621-631页
Preclinical experiments suggest protective effects of omega-3 fatty acids and their metabolites in lung injury and fibrosis. Whether higher intake of omega-3 fatty acids is associated with disease progression and survival in humans with pulmonary fibrosis is unknown.
1459. Individual Risk Factors of PM2.5 Associated With Wintertime Mortality in Urban Patients With COPD.
作者: Jordan Aron.;Arianne K Baldomero.;Austin Rau.;Mark B Fiecas.;Christine H Wendt.;Jesse D Berman.
来源: Chest. 2024年165卷4期825-835页
Air pollution contributes to premature mortality, but potential impacts differ in populations with existing disease, particularly for individuals with multiple risk factors. Although COPD increases vulnerability to air pollution, individuals with COPD and other individual risk factors are at the intersection of multiple risks and may be especially susceptible to the effect of acute outdoor air pollution.
1460. Creation and Validation of a Massive Hemoptysis Simulator.
作者: Melissa L New.;Timothy Amass.;Anna Neumeier.;Nicholas M Jacobson.;Tristan J Huie.
来源: Chest. 2024年165卷3期636-644页
Simulation for the management of massive hemoptysis is limited by the absence of a commercially available simulator to practice procedural skills necessary for management.
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