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101. Unlocking novel T cell-based immunotherapy for hepatocellular carcinoma through neoantigen-driven T cell receptor isolation.
作者: Panagiota Maravelia.;Haidong Yao.;Curtis Cai.;Daniela Nascimento Silva.;Jennifer Fransson.;Ola B Nilsson.;Yong-Chen William Lu.;Patrick Micke.;Johan Botling.;Francesca Gatto.;Giulia Rovesti.;Mattias Carlsten.;Matti Sallberg.;Per Stål.;Carl Jorns.;Marcus Buggert.;Anna Pasetto.
来源: Gut. 2025年
Tumour-infiltrating T cells can mediate both antitumour immunity and promote tumour progression by creating an immunosuppressive environment. This dual role is especially relevant in hepatocellular carcinoma (HCC), characterised by a unique microenvironment and limited success with current immunotherapy.
103. Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy - a multi-arm randomised controlled trial (HELIOS).
作者: Maarten Te Groen.;Anouk M Wijnands.;Nathan den Broeder.;Dirk J de Jong.;Willemijn A van Dop.;Marjolijn Duijvestein.;Herma H Fidder.;Fiona van Schaik.;Meike M C Hirdes.;Andrea E van der Meulen-de Jong.;P W Jeroen Maljaars.;Philip W Voorneveld.;K H Nanne de Boer.;Charlotte P Peters.;Bas Oldenburg.;Frank Hoentjen.; .
来源: Gut. 2025年74卷4期547-556页
It remains unclear if the increased colorectal neoplasia detection rate in inflammatory bowel disease (IBD) by high-definition (HD) dye-based chromoendoscopy compared with HD white-light endoscopy is due to enhanced contrast or increased inspection times. Longer withdrawal times may yield similar neoplasia detection rates as found by HD chromoendoscopy.
105. Targeting MXD1 sensitises pancreatic cancer to trametinib.
作者: Shaoping Zhang.;Shuang Deng.;Ji Liu.;Shuang Liu.;Ziming Chen.;Shaoqiu Liu.;Chunling Xue.;Lingxing Zeng.;Hongzhe Zhao.;Zilan Xu.;Sihan Zhao.;Yifan Zhou.;Xinyi Peng.;Xiaoyu Wu.;Ruihong Bai.;Shaojia Wu.;Mei Li.;Jian Zheng.;Dongxin Lin.;Jialiang Zhang.;Xudong Huang.
来源: Gut. 2025年
The resistance of pancreatic ductal adenocarcinoma (PDAC) to trametinib therapy limits its clinical use. However, the molecular mechanisms underlying trametinib resistance in PDAC remain unclear.
108. Withdrawal of antitumour necrosis factor in inflammatory bowel disease patients in remission: a randomised placebo-controlled clinical trial of GETECCU.
作者: Javier P Gisbert.;María G Donday.;Sabino Riestra.;Alfredo J Lucendo.;José-Manuel Benítez.;Mercè Navarro-Llavat.;Jesús Barrio.;Víctor J Morales-Alvarado.;Montserrat Rivero.;David Busquets.;Eduardo Leo Carnerero.;Olga Merino.;Óscar Nantes Castillejo.;Pablo Navarro.;Manuel Van Domselaar.;Ana Gutiérrez.;Inmaculada Alonso-Abreu.;Rafael Mejuto.;Luis Fernández-Salazar.;Marisa Iborra.;María Dolores Martín-Arranz.;Juan Ramón Pineda.;Manuela Josefa Sampedro.;Katja Serra Nilsson.;Abdel Bouhmidi.;Lissette Batista.;Carmen Muñoz Villafranca.;Iago Rodríguez-Lago.;Daniel Ceballos.;Iván Guerra.;Miriam Mañosa.;Ignacio Marín Jiménez.;Emilio Torrella.;Maribel Vera Mendoza.;María José Casanova.;Ruth de Francisco.;Laura Arias-González.;Sandra Marín Pedrosa.;Orlando García-Bosch.;Francisco Javier García-Alonso.;Pedro Delgado-Guillena.;María José García.;Leyanira Torrealba.;Andrea Núñez-Ortiz.;Miren Vicuña Arregui.;Marta Maia Bosca-Watts.;Isabel Blázquez.;Diana Acosta.;Ana Garre.;Montse Baldán.;Concepción Martínez.;Manuel Barreiro-de Acosta.;Eugeni Domènech.;Maria Esteve.;Valle García-Sánchez.;Pilar Nos.;Julián Panés.;María Chaparro.; .
来源: Gut. 2025年74卷3期387-396页
Primary objectives: to compare the rates of sustained clinical remission at 12 months in patients treated with antitumour necrosis factor (anti-TNF) and immunomodulators who withdraw anti-TNF treatment versus those who maintain it.
109. Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control.
作者: Shannon Nicole Russell.;Constantinos Demetriou.;Giampiero Valenzano.;Alice Evans.;Simei Go.;Tess Stanly.;Ahmet Hazini.;Frances Willenbrock.;Alex Nicolas Gordon-Weeks.;Somnath Mukherjee.;Matthias Tesson.;Jennifer P Morton.;Eric O'Neill.;Keaton Ian Jones.
来源: Gut. 2025年74卷5期825-839页
The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways that regulate macrophage phenotype are of strategic interest, with reprogramming strategies focusing on inhibitors of phosphoinositide 3-kinase-gamma (PI3Kγ) due to restricted immune cell expression. Inhibition of PI3Kγ alone is ineffective in PDAC, despite increased infiltration of CD8+ T cells.
111. Construction of exosome non-coding RNA feature for non-invasive, early detection of gastric cancer patients by machine learning: a multi-cohort study.
作者: Ze-Rong Cai.;Yong-Qiang Zheng.;Yan Hu.;Meng-Yao Ma.;Yi-Jin Wu.;Jia Liu.;Lu-Ping Yang.;Jia-Bo Zheng.;Tian Tian.;Pei-Shan Hu.;Ze-Xian Liu.;Lin Zhang.;Rui-Hua Xu.;Huai-Qiang Ju.
来源: Gut. 2025年
Gastric cancer (GC) remains a prevalent and preventable disease, yet accurate early diagnostic methods are lacking. Exosome non-coding RNAs (ncRNAs), a type of liquid biopsy, have emerged as promising diagnostic biomarkers for various tumours. This study aimed to identify a serum exosome ncRNA feature for enhancing GC diagnosis.
112. Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus.
作者: Jing Tong Tan.;Xianhua Mao.;Ho-Ming Cheng.;Wai-Kay Seto.;Wai-K Leung.;Ka-Shing Cheung.
来源: Gut. 2025年74卷4期603-612页
Patients with type 2 diabetes mellitus (T2DM) have higher pancreatic cancer (PC) risk. While aspirin has chemopreventive effects on digestive cancers, its effect on PC among patients with T2DM is unclear.
113. Accuracy of histopathology evaluation in diminutive colonic polyps diagnosed as neoplastic by computer-aided characterisation.
作者: Roupen Djinbachian.;Heiko Pohl.;Douglas K Rex.;Alan Barkun.;Cesare Hassan.;Geneviève Soucy.;Bich N Nguyen.;Daniel von Renteln.
来源: Gut. 2025年74卷5期703-705页 115. Trends and cross-country inequality in the incidence of GI cancers among the working-age population from 1990 to 2021: a Global Burden of Disease 2021 analysis.
作者: Yiming Song.;Xiaoyi Wang.;Yufeng Shen.;Liping Chen.;Liuyi Yang.;Ruilan Wang.;Junyu Lu.;Zhifang Gao.;Xiaolu Lin.;Yan Song.;Qingwei Zhang.;Xiaobo Li.
来源: Gut. 2024年
GI cancers pose an increasing global health burden, with their impact on the working-age population (WAP) aged 15-64 years remaining largely unexplored despite the crucial role of this group in societal and economic well-being.
118. Mutational signatures define immune and Wnt-associated subtypes of ampullary carcinoma.
作者: Ekaterina Zhuravleva.;Monika Lewinska.;Colm J O'Rourke.;Antonio Pea.;Asif Rashid.;Ann W Hsing.;Andrzej Taranta.;David Chang.;Yu-Tang Gao.;Jill Koshiol.;Rui Caetano Oliveira.;Jesper B Andersen.
来源: Gut. 2025年74卷5期804-814页
Ampullary carcinoma (AMPAC) taxonomy is based on morphology and immunohistochemistry. This classification lacks prognostic reliability and unique genetic associations. We applied an approach of integrative genomics characterising patients with AMPAC exploring molecular subtypes that may guide personalised treatments.
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