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1121. Upadacitinib in the treatment of Takayasu arteritis: a case report on new perspectives on targeted immunomodulation.
作者: Alexander Pfeil.;Wiebke Schulze.;Ulf Teichgräber.;Tobias Hoffmann.;Niklas Eckardt.;Christian Geis.;Falk Gühne.;Martin Freesmeyer.;Gunter Wolf.;Albrecht Günther.
来源: Rheumatology (Oxford). 2025年64卷9期5187-5188页 1122. CRTAC1: a novel indicator of lung involvement in SSc.
作者: Aneta Prokopcova.;Sabina Oreska.;Hana Wunsch.;Jiri Baloun.;Radim Becvar.;Ladislav Senolt.;Michal Tomcik.
来源: Rheumatology (Oxford). 2025年64卷8期4834-4838页
Interstitial lung disease (ILD) is the most frequent cause of mortality in patients with SSc. Cartilage acidic protein-1 (CRTAC1), secreted by alveolar type-2 epithelial cells, is a potential biomarker of lung health. This study explores CRTAC1's role in SSc, focusing on pulmonary involvement.
1123. Does body composition matter in patients with systemic sclerosis?
作者: Chiara Giraudo.;Giulia Fichera.;Marco Binda.;Beatrice Moccaldi.;Elisabetta Cocconcelli.;Anna Cuberli.;Anna Michielin.;Andrea Doria.;Roberto Stramare.;Elisabetta Balestro.;Elisabetta Zanatta.
来源: Rheumatology (Oxford). 2025年64卷10期5493-5497页
Body composition plays a significant role in various rheumatic and autoinflammatory diseases. The aim of our study was to assess the impact of muscle mass and subcutaneous adipose tissue quality and quantity in patients with SSc.
1124. Anti-mitochondrial antibodies as markers of disease activity in childhood-onset systemic lupus erythematosus: a longitudinal cohort study.
作者: Marina Barguil Macêdo.;Mohamed Javad Wahadat.;Albin Björk.;Sylvia Kamphuis.;Marjan A Versnel.;Christian Lood.
来源: Rheumatology (Oxford). 2025年64卷9期5096-5100页
Mitochondria are prominent antigenic sources, capable of triggering IFN-induced inflammatory pathways in SLE. Recent studies suggest presence of AMA in LN patients with adult-onset SLE. Whether AMA reflect disease activity in childhood-onset SLE (cSLE) remains unexplored. Here, we present inaugural data on the potential utility of AMA as a biomarker in cSLE.
1126. Characterization of fibroblast-like synoviocytes from the synovial fluid of patients affected by juvenile idiopathic arthritis.
作者: Simone Pelassa.;Federica Raggi.;Ignazia Prigione.;Francesca Ridella.;Angelo Ravelli.;Marco Gattorno.;Alessandro Consolaro.;Maria Carla Bosco.
来源: Rheumatology (Oxford). 2025年64卷9期5162-5171页
The objectives of this study were to characterize some phenotypic and functional aspects of fibroblast-like synoviocytes isolated from the Synovial Fluid (SF-FLSs) of patients affected by Juvenile Idiopathic Arthritis (JIA) with active disease and to compare SF-FLS characteristics with those reported in the literature for FLSs of the SM (Synovial Membrane) in adult rheumatic patients.
1127. The lack of association between cumulative MTX dose and liver fibrosis in PsA: a cohort study.
作者: Fadi Kharouf.;Pankti Mehta.;Virginia Carrizo Abarza.;Shangyi Gao.;Daniel Pereira.;Dafna D Gladman.;Denis Poddubnyy.;Vinod Chandran.
来源: Rheumatology (Oxford). 2025年64卷9期5090-5095页
Evidence for the association between MTX use and liver fibrosis in PsA remains inconclusive. We aimed to explore the frequency of liver fibrosis in PsA and identify associated factors including cumulative MTX dose and metabolic features.
1128. Continuous decline in Paget's disease of bone: a One Health perspective on 2342 new diagnoses and their association with rural livestock.
作者: Carmen Rebollo-Najera.;Ricardo Usategui-Martín.;Juan Lobato-Carrasco.;Marta Domínguez-Gil-González.;Jose Antonio Mirón-Canelo.;Pablo Miramontes-González.;Stuart H Ralston.;Luis Corral-Gudino.
来源: Rheumatology (Oxford). 2025年64卷9期5081-5089页
To characterize the incidence of clinically diagnosed Paget's disease of bone (PDB) in Castille and Leon, a region in the central plateau of Spain, from 2009 to 2019, and explores its association with environmental factors, particularly livestock activity.
1129. Association of matrix metalloproteinase 7 and the alpha-chain of fibrinogen at baseline with response to methotrexate at 3 months in patients with early rheumatoid arthritis.
作者: Karen Hambardzumyan.;Carl Hamsten.;Lucía Lourido.;Saedis Saevarsdottir.;Peter Nilsson.;Ronald F van Vollenhoven.;Per-Johan Jakobsson.;Helena Idborg.
来源: BMC Rheumatol. 2025年9卷1期56页
The identification of responders to methotrexate (MTX) would optimize the therapy of patients with early rheumatoid arthritis (eRA). Our aim was to identify protein biomarkers for the prediction of the response to MTX.
1130. The impact of intensive management on pain intensity in patients with rheumatoid arthritis and psoriatic arthritis: secondary analysis of three clinical trials.
Understanding the impact of intensive treatment on pain in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) is crucial to informing the application of evidence-based arthritis pain care. The impact of intensive treatment on inflammatory arthritis pain has received relatively limited attention. We addressed this through a detailed secondary analysis of three trials evaluating varying intensities of disease-modifying anti-rheumatic drug treatment. We considered a range of pain outcomes of clinical relevance to patients, including the achievement of mild endpoint pain scores and clinically-meaningful pain reductions.
1132. Leg edema in systemic sclerosis: uncovering fasciitis and myositis as key underlying causes.
作者: Shiri Keret.;Merav Lidar.;Aniela Shouval.;Abid Awisat.;Alaa Sawaed.;Noa Nemesh.;Lisa Kaly.;Itzhak Rosner.;Michael Rozenbaum.;Nina Boulman.;Gleb Slobodin.;Doron Rimar.
来源: Rheumatology (Oxford). 2025年64卷9期5184-5186页 1133. Meta-analysis revealed HLA susceptibility markers in ANCA-associated vasculitis and its clinical subtypes.
作者: Harinder Singh.;Koustav Maiti.;Sohini Saha.;Sabyasachi Senapati.
来源: Rheumatology (Oxford). 2025年64卷10期5208-5216页
ANCA-associated vasculitis (AAV) is a group of systemic autoimmune diseases affecting small blood-vessels. Class-II human leukocyte antigen (HLA) genes are often reported as major genetic determinants. We conducted a systematic review and meta-analysis to evaluate the susceptibility conferred by HLA genes to AAV and five of its clinical subtypes [PR3+AAV, MPO+AAV, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA)].
1134. NETs in the spotlight: exploring NETosis markers for tracking disease activity in IgA vasculitis.
作者: Vafa Guliyeva.;Fatma Gül Demirkan.;Erdem Bektaş.;Rabia Deniz.;Zeliha Emrence.;Özlem Akgün.;Selen Duygu Arık.;Ayşenur Doğru.;Ayşe Tanatar.;Neslihan Abacı.;Sema Sırma Ekmekci.;Ahmet Gül.;Nuray Aktay Ayaz.
来源: Rheumatology (Oxford). 2025年64卷10期5509-5517页
The role of neutrophil extracellular traps (NETs) in IgA vasculitis (IgAV) pathogenesis is emerging, with NETosis-associated markers potentially linked to disease activity. This study aimed to explore the relationship between NETosis biomarkers and IgAV disease phases.
1135. Evaluating the relevance of the 2024 BSR systemic sclerosis guideline for juvenile systemic sclerosis.
作者: Clare E Pain.;Hanna Lythgoe.;Emily Willis.;Sunil Sampath.;Samundeeswari Deepak.;Kathryn S Torok.;Phuoc H Duong.;Shahin Moledina.;Juliana Silva.;Clarissa Pilkington.;Eslam Al-Abadi.;Christopher P Denton.
来源: Rheumatology (Oxford). 2025年64卷9期5179-5181页 1137. The Fibrosis-4 Index (FIB-4) correlates with cardiovascular risk and insulin resistance in patients with rheumatoid arthritis.
作者: Iván Ferraz-Amaro.;Elena Heras-Recuero.;Antonia de Vera-González.;Alejandra González-Delgado.;Alejandro Romo-Cordero.;Adrián Quevedo-Rodríguez.;Juan C Quevedo-Abeledo.;Raquel Largo.;Miguel Á González-Gay.
来源: Rheumatology (Oxford). 2025年64卷9期5065-5073页
The Fibrosis-4 index (FIB-4), a non-invasive tool for assessing liver fibrosis, has also been linked to cardiovascular (CV) risk in the general population. This connection is due to the association of chronic liver diseases, particularly fibrosis or non-alcoholic fatty liver disease, with systemic inflammation, metabolic syndrome and atherosclerosis. In this study, we aimed to calculate the FIB-4 index in patients with rheumatoid arthritis (RA), a condition associated with increased CV disease risk. We then examined its association with disease characteristics and CV comorbidities, including lipid profile, subclinical carotid atherosclerosis and insulin resistance indices.
1139. Functional brain networks related to processing speed and memory in SLE: a connectome-based modelling study.
作者: Linhui Wang.;Qin Huang.;Jingyi Wang.;Fuqiang Wu.;Wenjun Hu.;Jiaying Mo.;Kunyu Zhuang.;Hai Lin.;Ruibin Zhang.;Xiangliang Tan.
来源: Rheumatology (Oxford). 2025年64卷9期5142-5150页
Cognitive dysfunction is a common neuropsychiatric manifestation in SLE, particularly affecting processing speed (PS) and memory. This study aims to identify behaviourally relevant topological networks of functional connectivity underlying neuropsychological test performances, using connectome-based predictive modelling (CPM).
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