Spondyloarthritides (SpA) are common entities of the inflammatory rheumatic type. There are still 3 relevant problems in everyday clinical practice: early disease detection, cardiovascular risk assessment, and less so, disease activity measurement. Metabolomics allows the quantification of a large number of small-molecule substances from biological samples.

Behçet's Disease (BD) is a chronic, systemic vasculitis of unknown etiology that affects multiple organ systems. It is characterized by recurrent oral and genital ulcers, ocular involvement, affecting arteries and veins of all sizes. It is more prevalent in countries along the ancient Silk Road. Diagnosis is primarily clinical, as there are no specific laboratory tests. The International Criteria for BD (ICBD) was developed to improve diagnostic accuracy. Management requires a multidisciplinary approach, with treatment strategies depending on disease severity. Despite BD's significant morbidity and diverse clinical manifestations, its prevalence and characteristics remain to be described in Palestine. This research provides critical insights into disease patterns and contributes to improved diagnosis and management in Palestine.

Anifrolumab, a monoclonal antibody targeting the type I interferon-α receptor, has been approved for the treatment of moderate-to-severe systemic lupus erythematosus (SLE). This study aimed to assess its safety profile in real-world settings.

Rituximab is known as an efficacious drug for the treatment of Rheumatoid Arthritis (RA). The original administration schedule consisted of two infusions of 1000 mg with a 2-week interval. We aimed to explore the long-term effectiveness of rituximab in daily clinical practice in patients with RA.

Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug (DMARD) for treating rheumatoid arthritis (RA). However, MTX use is associated with gastrointestinal adverse effects in a number of patients. Early detection of MTX intolerance could help modify the treatment strategy, thereby ensuring patient compliance and response. In the present study we aimed to identify the prevalence of MTX intolerance, and associated risk factors in a cohort of Indian RA patients receiving oral MTX therapy.

Systemic lupus erythematosus is a complex and increasingly prevalent disease that presents substantial challenges in both diagnosis and management. Diagnostic delays frequently lead to irreversible organ damage, and remain a crucial concern, mainly among vulnerable populations, such as minority ethnic groups and those living in the global south. These delays are exacerbated by the clinical heterogeneity of systemic lupus erythematosus, the lack of specific diagnostic biomarkers, gaps in disease awareness or medical training, and persistent health care disparities, particularly in low-resource settings. This Perspective highlights the urgent need for a standardized definition of diagnostic delay that accounts for both clinical and socio-economic factors. By prioritizing early intervention and expanding access to specialized care, we can improve patient outcomes and reduce the long-term burden of the disease.

Similarly to polymyalgia rheumatica (PMR), calcium pyrophosphate deposition (CPPD) disease is common among older people. Calcium pyrophosphate deposition can present in several forms, including proximal manifestations associated with raised inflammatory markers. Consequently, CPPD disease may be diagnosed as PMR. Recently, a European Alliance of Associations for Rheumatology and American College of Rheumatology (EULAR/ACR) collaborative initiative proposed new classification criteria for symptomatic CPPD disease. This review paper aimed to discuss when CPPD disease could be considered a PMR-mimicking disease in the light of these criteria.

This literature review provides a comprehensive overview of the use of complementary and alternative modalities for the treatment of autoimmune diseases, which pose a significant challenge in contemporary healthcare, often requiring long-term management with conventional therapies. It explores a diverse range of complementary and alternative therapies, including herbal remedies, dietary interventions, mind-body practices, and emerging therapies, in the context of the management of several autoimmune diseases, highlighting increased patient satisfaction, pain management and adaptation. The findings shed light on the evolving role of complementary and alternative medicine in addressing autoimmune diseases, emphasizing the importance of a holistic approach to patient care.

Axial spondyloarthritis (axSpA) comprises a group of chronic inflammatory joint diseases. Modern therapies enable the rapid achievement of low disease activity or even remission. Therefore, assessing disease activity is now crucial for making the best possible therapeutic decisions. In addition to standard clinical indices used to evaluate disease activity, magnetic resonance imaging (MRI) is increasingly employed to assess inflammation.

Juvenile idiopathic arthritis is the most common rheumatic chronic disease in children, typically characterised by joint pain and swelling, fatigue, stiffness, muscle weakness and movement restrictions. As a consequence, children are exposed to bone atrophy, physical disability, social separation and reduced quality of life. It is believed that early implementation of targeted pharmacological treatment such as nonsteroidal anti-inflammatory drugs, disease-modifying agents and biological therapies is necessary to ensure full recovery. Recent recommendations emphasize the importance of nonpharmacologic treatments, e.g. nutrition, supplements and physical or occupational therapies, as an important component of a complex therapy. In this article, we review recent studies, summarising the impact of different physical interventions on children with juvenile idiopathic arthritis on muscle, bone and psychological function to provide a basis for more detailed recommendations of physical activity for children with arthritis.

Thoracic spine pain syndrome is far less common than lumbosacral or cervical pain. This pathology is often caused by work-related overload, especially sedentary work, lack of regular sport activities, and adopting incorrect postures. Thoracic spine pain may result, for instance, from degenerative joint lesions. In consequence, there is a reflex contraction of the soft, paraspinal tissues (muscles, fascia, ligaments). In this case, one of the treatment methods is spinal mesotherapy. The purpose of the present research was to evaluate the effectiveness and safety of thoracic spinal mesotherapy with collagen type I vs. lignocaine.

Radiosynoviorthesis is a minimally invasive treatment for inflammatory joint disorders. It is an alternative to surgical synovectomy and is used when systemic treatment and intraarticular glucocorticosteroid injections have failed. This literature review summarizes the effectiveness of this method in various inflammatory joint disorders. A systematic literature search was performed in the PubMed, Embase, Web of Science and DOAJ databases. Depending on the type of inflammation and level of joint destruction, the effectiveness of therapy is 50-80%, up to even 90-100% in hemarthrosis. The present study demonstrates that the therapy is safe, with almost no side-effects. It provides long-term cost-effectiveness for patients due to its ambulatory characteristics, does not require rehabilitation, and leads to reduced use of other therapies. Moreover, it may be used as an independent type of therapy as well as a part of complex treatment. Given its benefits, the method should be considered by specialists of various fields.

This study outlines the diagnostic and therapeutic approaches - both pharmacological and non-pharmacological - used by Moroccan rheumatologists in managing fibromyalgia (FM). It also addresses other key aspects, such as assessing the psychosocial context of patients and referring them to other medical specialties.

The aim was to assess osteocalcin (OC) and N-terminal telopeptide of type I collagen (NTx) levels in men with ankylosing spondylitis (AS) and evaluate their relationship with the course of the disease and the structural and functional state of bone tissue.