We (1) compared anxiety symptom levels in a multinational SSc cohort to a general population normative sample and (2) evaluated sociodemographic, lifestyle and SSc disease factors associated with symptoms.

Pain is the primary complaint in individuals with osteoarthritis (OA) and changes as the disease progresses. Anatomical changes in several joint structures potentially contribute to pain, including the increased innervation of the periosteum, synovium and subchondral bone, and the pathological innervation of articular cartilage, which is aneural under physiological conditions. Research has focused on molecules that sensitize afferent neurons, such as neuropeptides, neurotrophins, pro-inflammatory cytokines and ion channels. The neurotrophin nerve growth factor (NGF) is the best validated target in OA pain, with proven analgesic effects in preclinical and clinical studies, although the development of NGF-targeted therapeutics has been hampered by serious side effects. One relatively neglected area of research is the contribution to OA pain of the molecular pathways that mediate remodelling of nerves in disease. Remodelling requires coordination between the nerve and the associated vasculature, along with signals that are received from the surrounding parenchyma. Key cell guidance molecules, including angiogenic factors, ephrins, semaphorins and SLIT proteins are involved in nerve growth during development, and their expression is increased in osteoarthritic joints.

To identify phenotypic damage pattern at 15 years and predictors of long-term damage at diagnosis in a multicentre Sjögren's disease (SjD) cohort.

Oesophageal dysmotility is a common manifestation of SSc, contributing to substantial morbidity. We sought to determine whether oesophageal dysmotility patterns by high-resolution oesophageal manometry were associated with distinct SSc clinical phenotypes and different outcomes.

To investigate whether clinical outcomes and patient-reported outcomes (PROs) differ over 2 years based on the age of onset of RA.

To explore health-related quality of life (HRQoL), anxiety, depression and fatigue among persons with ANCA-associated vasculitis (AAV).

The relationship between dietary mineral intakes and the risk of rheumatoid arthritis (RA) remains limited. This study aims to investigate the associations between dietary mineral intakes with RA.

To determine the prevalence and incidence of scleroderma renal crisis (SRC) in patients with SSc over two time periods and to identify factors influencing potential epidemiological changes.

To evaluate the absolute and relative risk of venous thromboembolism (VTE) in individuals with RA, with relation to age, sex, BMI, disease duration and exposure to exogenous oestrogens.

To explore self-reported cognitive dysfunction, including memory impairment, across systemic autoimmune rheumatic diseases (SARDs) and examine its impact and associations with demographic, clinical and psychosocial factors.

Giant cell arteritis (GCA) is a large vessel vasculitis characterized by arterial wall inflammation and remodelling. Macrophages and fibroblasts are abundantly present in arteries affected by GCA, but their crosstalk in GCA pathogenesis is largely unknown. Here we investigated the interaction between macrophages and fibroblasts in GCA-affected arteries and in vitro.

Plant homeodomain (PHD) fingers are present in many chromatin-binding proteins. We recently discovered that anti-Mi2 autoantibodies recognize PHD fingers in Mi2 and AIRE. The purpose of this study was to characterize anti-Mi2 autoantibody recognition of PHD fingers in SP140L and TIF1γ as well as to explore recognition of TIF1γ by both anti-TIF1γ and anti-Mi2 autoantibodies.

To capture the current evidence on therapeutic interventions and prognostic factors in PMR informing a task force of the German, Austrian and Swiss rheumatology societies formulating the updated recommendations for the management of PMR.

Functional autoantibodies targeting IFNs can lead to immunodeficiency and have been implicated in various autoimmune diseases. Despite the critical role of interferons in myositis pathogenesis, the significance of anti-IFN autoantibodies in inflammatory myopathies remains poorly understood. This study aimed to investigate the prevalence and functional impact of anti-IFN autoantibodies in patients with myositis.

Using Rasch measurement theory, an item pool of 12 questions has been identified, covering tenderness and swelling, disease activity, pain, physical functioning and stiffness for assessing the construct of RA disease activity. This study aimed to assess the content validity of this item pool using cognitive interviews.

HBV reactivation is a critical concern for patients with autoimmune disease undergoing immunosuppressive therapy. Despite data on HBV reactivation risks associated with biologics, the impact of the new targeted immunosuppressive agents-Janus kinase inhibitors (JAKis)-remains unclear. This study aimed to evaluate the risk of HBV reactivation among patients with RA treated with JAKis, compared with those receiving TNF inhibitors (TNFis) or rituximab.