当前位置: 首页 >> 检索结果
701. Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target.
作者: Eloi R Verrier.;Gaëtan Ligat.;Laura Heydmann.;Katharina Doernbrack.;Julija Miller.;Anne Maglott-Roth.;Frank Jühling.;Houssein El Saghire.;Margaux J Heuschkel.;Naoto Fujiwara.;Sen-Yung Hsieh.;Yujin Hoshida.;David E Root.;Emanuele Felli.;Patrick Pessaux.;Atish Mukherji.;Laurent Mailly.;Catherine Schuster.;Laurent Brino.;Michael Nassal.;Thomas F Baumert.
来源: Gut. 2022年72卷9期1745-57页
Chronic hepatitis B virus (HBV) infection is a leading cause of liver disease and hepatocellular carcinoma. A key feature of HBV replication is the synthesis of the covalently close circular (ccc)DNA, not targeted by current treatments and whose elimination would be crucial for viral cure. To date, little is known about cccDNA formation. One major challenge to address this urgent question is the absence of robust models for the study of cccDNA biology.
702. Empirical rescue treatment of Helicobacter pylori infection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry on H. pylori management (Hp-EuReg).
作者: Diego Burgos-Santamaría.;Olga P Nyssen.;Antonio Gasbarrini.;Dino Vaira.;Ángeles Pérez-Aisa.;Luís Rodrigo.;Rinaldo Pellicano.;Alma Keco-Huerga.;Manuel Pabón-Carrasco.;Manuel Castro-Fernandez.;Doron Boltin.;Jesus Barrio.;Perminder Phull.;Juozas Kupcinskas.;Laimas Jonaitis.;Inmaculada Ortiz-Polo.;Bojan Tepes.;Alfredo J Lucendo.;José María Huguet.;Miguel Areia.;Natasa Brglez Jurecic.;Maja Denkovski.;Luís Bujanda.;June Ramos-San Román.;Antonio Cuadrado-Lavín.;Judith Gomez-Camarero.;Manuel Alfonso Jiménez Moreno.;Angel Lanas.;Samuel Jesús Martinez-Dominguez.;Enrique Alfaro.;Ricardo Marcos-Pinto.;Vladimir Milivojevic.;Theodore Rokkas.;Marcis Leja.;Sinead Smith.;Ante Tonkić.;György Miklós Buzás.;Michael Doulberis.;Marino Venerito.;Frode Lerang.;Dmitry S Bordin.;Vincent Lamy.;Lisette G Capelle.;Wojciech Marlicz.;Daniela Dobru.;Oleksiy Gridnyev.;Ignasi Puig.;Francis Mégraud.;Colm O'Morain.;Javier P Gisbert.; .
来源: Gut. 2022年
To evaluate the use, effectiveness and safety of Helicobacter pylori empirical rescue therapy in third and subsequent treatment lines in Europe.
703. Lifestyle factors for the prevention of inflammatory bowel disease.
作者: Emily W Lopes.;Simon S M Chan.;Mingyang Song.;Jonas F Ludvigsson.;Niclas Håkansson.;Paul Lochhead.;Allan Clark.;Kristin E Burke.;Ashwin N Ananthakrishnan.;Amanda J Cross.;Domenico Palli.;Manuela M Bergmann.;James M Richter.;Andrew T Chan.;Ola Olén.;Alicja Wolk.;Hamed Khalili.; .
来源: Gut. 2022年
To estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors.
706. Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines.
作者: Roy Hajjar.;Emmanuel Gonzalez.;Gabriela Fragoso.;Manon Oliero.;Ahmed Amine Alaoui.;Annie Calvé.;Hervé Vennin Rendos.;Souad Djediai.;Thibault Cuisiniere.;Patrick Laplante.;Claire Gerkins.;Ayodeji Samuel Ajayi.;Khoudia Diop.;Nassima Taleb.;Sophie Thérien.;Frédéricke Schampaert.;Hefzi Alratrout.;François Dagbert.;Rasmy Loungnarath.;Herawaty Sebajang.;Frank Schwenter.;Ramses Wassef.;Richard Ratelle.;Eric Debroux.;Jean-François Cailhier.;Bertrand Routy.;Borhane Annabi.;Nicholas J B Brereton.;Carole Richard.;Manuela M Santos.
来源: Gut. 2023年72卷6期1143-1154页
Colorectal cancer (CRC) is the third most diagnosed cancer, and requires surgical resection and reconnection, or anastomosis, of the remaining bowel to re-establish intestinal continuity. Anastomotic leak (AL) is a major complication that increases mortality and cancer recurrence. Our objective is to assess the causal role of gut microbiota in anastomotic healing.
707. COVID-19 vaccine effectiveness and community prevalence of Alpha, Delta and Omicron variants in patients with cirrhosis.
作者: Binu V John.;Dustin R Bastaich.;Raphaella D Ferreira.;Akash Doshi.;Tamar H Taddei.;David E Kaplan.;Seth Spector.;Yangyang Deng.;Bassam Dahman.
来源: Gut. 2023年72卷9期1800-1802页 708. Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination.
作者: Genelle Rose Lunken.;Liam Golding.;Alana Schick.;Abdelilah Majdoubi.;Pascal M Lavoie.;Bruce Andrew Vallance.
来源: Gut. 2023年73卷1期208-210页 709. Production and possible reduction of greenhouse gases produced during GI endoscopy activity: a systematic review of available literature.
作者: Abhilash Perisetti.;Madhav Desai.;Michael J Bourke.;Ian Penman.;Alessandro Repici.;Duvvur Nageshwar Reddy.;Hisao Tajiri.;Douglas K Rex.;Cesare Hassan.;Prateek Sharma.
来源: Gut. 2023年72卷3期493-500页
Greenhouse gases (GHGs) that trap heat in the atmosphere are composed of carbon dioxide (CO2), methane, nitrous oxide and fluorinated gases (synthetic hydrofluorocarbons, perfluorocarbons and nitrogen trifluoride). In the USA, the health sector accounts for 8.5% of total GHG emissions. The primary objective of this systematic review was to critically analyse the carbon emissions data from GI endoscopic activity.
710. Cardiovascular disease risk in paediatric and young adult non-alcoholic fatty liver disease.
作者: Tracey G Simon.;Bjorn Roelstraete.;Naim Alkhouri.;Hannes Hagström.;Johan Sundström.;Jonas F Ludvigsson.
来源: Gut. 2023年72卷3期573-580页
Longitudinal evidence is lacking regarding the long-term risk of major adverse cardiovascular events (MACE) in children and young adults with non-alcoholic fatty liver disease (NAFLD).
712. Isoformic PD-1-mediated immunosuppression underlies resistance to PD-1 blockade in hepatocellular carcinoma patients.
作者: Zhiwu Tan.;Mei Sum Chiu.;Xinxiang Yang.;Ming Yue.;Tan To Cheung.;Dongyan Zhou.;Yuewen Wang.;Anthony Wing-Hung Chan.;Chi Wing Yan.;Ka Yi Kwan.;Yik Chun Wong.;Xin Li.;Jingying Zhou.;Ka Fai To.;Jiye Zhu.;Chung Mau Lo.;Alfred Sze-Lok Cheng.;Stephen Lam Chan.;Li Liu.;You-Qiang Song.;Kwan Man.;Zhiwei Chen.
来源: Gut. 2023年72卷8期1568-1580页
Immune checkpoint blockade (ICB) has improved cancer treatment, yet why most hepatocellular carcinoma (HCC) patients are resistant to PD-1 ICB remains elusive. Here, we elucidated the role of a programmed cell death protein 1 (PD-1) isoform, Δ42PD-1, in HCC progression and resistance to nivolumab ICB.
713. EUS-guided drainage of large walled-off pancreatic necroses using plastic versus lumen-apposing metal stents: a single-centre randomised controlled trial.
作者: John Gásdal Karstensen.;Srdan Novovic.;Erik Feldager Hansen.;Annette Bojer Jensen.;Henrik Lovendahl Jorgensen.;Morten Laksafoss Lauritsen.;Mikkel Parsberg Werge.;Palle Nordblad Schmidt.
来源: Gut. 2023年72卷6期1167-1173页
In treating pancreatic walled-off necrosis (WON), lumen-apposing metal stents (LAMS) have not proven superior to the traditional double pigtail technique (DPT). Among patients with large WON (>15 cm) and their associated substantial risk of treatment failure, the increased drainage capacity of a novel 20-mm LAMS might improve clinical outcomes. Hence, we conducted a study comparing the DPT and 20-mm LAMS in patients with large WON.
714. Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis.
作者: Jessica Roelands.;Manon van der Ploeg.;Marieke E Ijsselsteijn.;Hao Dang.;Jurjen J Boonstra.;James C H Hardwick.;Lukas J A C Hawinkels.;Hans Morreau.;Noel F C C de Miranda.
来源: Gut. 2023年72卷7期1326-1339页
Biological insights into the stepwise development and progression of colorectal cancer (CRC) are imperative to develop tailored approaches for early detection and optimal clinical management of this disease. Here, we aimed to dissect the transcriptional and immunologic alterations that accompany malignant transformation in CRC and to identify clinically relevant biomarkers through spatial profiling of pT1 CRC samples.
715. Crohn's-associated invariant T cells (CAITs) recognise small sulfonate molecules on CD1d.
作者: Anastasia A Minervina.;Mikhail V Pogorelyy.;Steffen Paysen.;Ulrich Luening.;Frauke Degenhardt.;Andre Franke.;Paul G Thomas.;Elisa Rosati.
来源: Gut. 2023年73卷1期205-206页 717. Response to: Correspondence on 'On the ethics of digestive health research in historically marginalised communities' by Velez and Targownick.
作者: Emad Mansoor.;Scott A Martin.;Abe Perez.;Vu Quang Nguyen.;Jeffry Katz.;Shubham Gupta.;Fabio Cominelli.
来源: Gut. 2023年72卷12期2388页 720. Health-code-based triage versus universal COVID-19 PCR testing before endoscopy in a low incidence area: a real-world experience.
作者: Zhihui Duan.;Dengxiang Liu.;Shengyun Zhou.;Hui Li.;Xiaofang Sun.;Chunqian Zhao.;Qiong Duan.;Liwei Li.;Xiaochong Zhang.;Lingxuan Jin.
来源: Gut. 2023年72卷2期223-225页 |