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6801. What is the role of tiotropium in asthma?: a systematic review with meta-analysis.
The role of tiotropium for the treatment of asthma has not yet been clearly defined. The aim of this systematic review was to assess the efficacy and safety of tiotropium in patients with asthma.
6802. The effect of omega-3 fatty acids on bronchial hyperresponsiveness, sputum eosinophilia, and mast cell mediators in asthma.
作者: John D Brannan.;Johan Bood.;Ahmad Alkhabaz.;David Balgoma.;Joceline Otis.;Ingrid Delin.;Barbro Dahlén.;Craig E Wheelock.;Parameswaran Nair.;Sven-Erik Dahlén.;Paul M O'Byrne.
来源: Chest. 2015年147卷2期397-405页
Omega-3 fatty acid supplements have been reported to inhibit exercise-induced bronchoconstriction (EIB). It has not been determined whether omega-3 supplements inhibit airway sensitivity to inhaled mannitol, a test for bronchial hyperresponsiveness (BHR) and model for EIB in people with mild to moderate asthma.
6803. Nighttime intensivist staffing, mortality, and limits on life support: a retrospective cohort study.
作者: Meeta Prasad Kerlin.;Michael O Harhay.;Jeremy M Kahn.;Scott D Halpern.
来源: Chest. 2015年147卷4期951-958页
Evidence regarding nighttime physician staffing of ICUs is suboptimal. We aimed to determine how nighttime physician staffing models influence patient outcomes.
6804. Prevention of acute exacerbations of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline.
作者: Gerard J Criner.;Jean Bourbeau.;Rebecca L Diekemper.;Daniel R Ouellette.;Donna Goodridge.;Paul Hernandez.;Kristen Curren.;Meyer S Balter.;Mohit Bhutani.;Pat G Camp.;Bartolome R Celli.;Gail Dechman.;Mark T Dransfield.;Stanley B Fiel.;Marilyn G Foreman.;Nicola A Hanania.;Belinda K Ireland.;Nathaniel Marchetti.;Darcy D Marciniuk.;Richard A Mularski.;Joseph Ornelas.;Jeremy D Road.;Michael K Stickland.
来源: Chest. 2015年147卷4期894-942页
COPD is a major cause of morbidity and mortality in the United States as well as throughout the rest of the world. An exacerbation of COPD (periodic escalations of symptoms of cough, dyspnea, and sputum production) is a major contributor to worsening lung function, impairment in quality of life, need for urgent care or hospitalization, and cost of care in COPD. Research conducted over the past decade has contributed much to our current understanding of the pathogenesis and treatment of COPD. Additionally, an evolving literature has accumulated about the prevention of acute exacerbations.
6805. Hospitalization and survival in patients using epoprostenol for injection in the PROSPECT observational study.
作者: Robert P Frantz.;Robert J Schilz.;Murali M Chakinala.;David B Badesch.;Adaani E Frost.;Vallerie V McLaughlin.;Robyn J Barst.;Daniel M Rosenberg.;Dave P Miller.;Brian K Hartline.;Wade W Benton.;Harrison W Farber.
来源: Chest. 2015年147卷2期484-494页
Few studies have prospectively reported outcomes in patients with pulmonary arterial hypertension (PAH) treated with epoprostenol in the modern-day era of oral therapy and combination treatments. The Registry to Prospectively Describe Use of Epoprostenol for Injection (Veletri, prolonged room temperature stable-epoprostenol [RTS-Epo]) in Patients with Pulmonary Arterial Hypertension (PROSPECT) was established to prospectively describe the course of PAH in patients prescribed RTS-Epo.
6806. Executive summary: prevention of acute exacerbation of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline.
作者: Gerard J Criner.;Jean Bourbeau.;Rebecca L Diekemper.;Daniel R Ouellette.;Donna Goodridge.;Paul Hernandez.;Kristen Curren.;Meyer S Balter.;Mohit Bhutani.;Pat G Camp.;Bartolome R Celli.;Gail Dechman.;Mark T Dransfield.;Stanley B Fiel.;Marilyn G Foreman.;Nicola A Hanania.;Belinda K Ireland.;Nathaniel Marchetti.;Darcy D Marciniuk.;Richard A Mularski.;Joseph Ornelas.;Jeremy D Road.;Michael K Stickland.
来源: Chest. 2015年147卷4期883-893页 6807. CT scan findings of probable usual interstitial pneumonitis have a high predictive value for histologic usual interstitial pneumonitis.
作者: Jonathan H Chung.;Ashish Chawla.;Anna L Peljto.;Carlyne D Cool.;Steve D Groshong.;Janet L Talbert.;David F McKean.;Kevin K Brown.;Tasha E Fingerlin.;Marvin I Schwarz.;David A Schwartz.;David A Lynch.
来源: Chest. 2015年147卷2期450-459页
The current usual interstitial pneumonitis (UIP)/idiopathic pulmonary fibrosis CT scan classification system excludes probable UIP as a diagnostic category. We sought to determine the predictive effect of probable UIP on CT scan on histology and the effect of the promoter polymorphism in MUC5B (rs35705950) on histologic and CT scan UIP diagnosis.
6808. Noninvasive positive pressure ventilation following esophagectomy: safety demonstrated in a pig model.
Respiratory complications occur in 20% to 65% of patients who have undergone esophagectomy. While noninvasive positive pressure ventilation (NPPV) is associated with fewer complications than endotracheal intubation (ET), it is relatively contraindicated after esophagectomy due to potential injury to the anastomosis. We created ex vivo and in vivo pig models to determine the pressure tolerance of an esophagectomy anastomosis and compare it to esophageal pressure during NPPV.
6809. Preintubation application of oral chlorhexidine does not provide additional benefit in prevention of early-onset ventilator-associated pneumonia.
作者: Cindy L Munro.;Mary Jo Grap.;Curtis N Sessler.;Ronald K Elswick.;Devanand Mangar.;Rachel Karlnoski-Everall.;Paula Cairns.
来源: Chest. 2015年147卷2期328-334页
Daily application of oral chlorhexidine gluconate (CHX) following intubation to reduce the risk of ventilator-associated pneumonia (VAP) is now the standard of care in many ICUs. This randomized clinical trial evaluated the benefit of adding a preintubation CHX dose to the known benefit of postintubation CHX to reduce the risk of early-onset VAP. A secondary aim was to test the effect of a preintubation oral application of CHX on early endotracheal tube (ETT) colonization.
6810. Prognostic accuracy of clinical prediction rules for early post-pulmonary embolism all-cause mortality: a bivariate meta-analysis.
作者: Christine G Kohn.;Elizabeth S Mearns.;Matthew W Parker.;Adrian V Hernandez.;Craig I Coleman.
来源: Chest. 2015年147卷4期1043-1062页
Studies suggest outpatient treatment or early discharge of patients with acute pulmonary embolism (aPE) is reasonable for those deemed to be at low risk of early mortality. We sought to determine clinical prediction rule accuracy for identifying patients with aPE at low risk for mortality.
6811. Ventilation/Perfusion distribution abnormalities in morbidly obese subjects before and after bariatric surgery.
作者: Eva Rivas.;Ebymar Arismendi.;Alvar Agustí.;Marcelo Sanchez.;Salvadora Delgado.;Concepción Gistau.;Peter D Wagner.;Roberto Rodriguez-Roisin.
来源: Chest. 2015年147卷4期1127-1134页
Obesity is a global and growing public health problem. Bariatric surgery (BS) is indicated in patients with morbid obesity. To our knowledge, the effects of morbid obesity and BS on ventilation/perfusion (V.a/Q.) ratio distributions using the multiple inert gas elimination technique have never before been explored.
6812. Bardet Biedl syndrome: motile ciliary phenotype.
Cilia line the surface of the respiratory tract and beat in a coordinated wave to protect the lungs against infection. Bardet Biedl Syndrome (BBS) is a rare condition attributed to cilia dysfunction. Murine models of BBS suggest a respiratory phenotype; however, no reports have studied the translation of these findings in patients.
6813. Development of a novel, multilayered presentation format for clinical practice guidelines.
作者: Annette Kristiansen.;Linn Brandt.;Pablo Alonso-Coello.;Thomas Agoritsas.;Elie A Akl.;Tara Conboy.;Mahmoud Elbarbary.;Mazen Ferwana.;Wedad Medani.;Mohammad Hassan Murad.;David Rigau.;Sarah Rosenbaum.;Frederick A Spencer.;Shaun Treweek.;Gordon Guyatt.;Per Olav Vandvik.
来源: Chest. 2015年147卷3期754-763页
Bridging the gap between clinical research and everyday health-care practice requires effective communication strategies. To address current shortcomings in conveying practice recommendations and supporting evidence, we are creating and testing presentation formats for clinical practice guidelines (CPGs).
6814. Pulmonary arterial hypertension in the southern hemisphere: results from a registry of incident Brazilian cases.
作者: Jose Leonidas Alves.;Francisca Gavilanes.;Carlos Jardim.;Caio Julio Cesar Dos Santos Fernandes.;Luciana Tamie Kato Morinaga.;Bruno Dias.;Susana Hoette.;Marc Humbert.;Rogerio Souza.
来源: Chest. 2015年147卷2期495-501页
Pulmonary arterial hypertension (PAH) is a rare and ultimately fatal disorder of the pulmonary vasculature. There is increasing interest in the worldwide characteristics of patients with PAH, although data coming from the Southern Hemisphere remain scarce. The objective of this study was to describe a cohort of incident patients with PAH from a large reference center in Brazil.
6815. The clinical course of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
作者: Laurie L Carr.;Jonathan H Chung.;Rosane Duarte Achcar.;Zoran Lesic.;Ji Y Rho.;Kunihiro Yagihashi.;Robert M Tate.;Jeffrey J Swigris.;Jeffrey A Kern.
来源: Chest. 2015年147卷2期415-422页
Current understanding of the clinical course of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is poor and based predominantly on small case series. In our clinical experience, we have found that the diagnosis of DIPNECH is frequently delayed because respiratory symptoms are ascribed to other lung conditions. The objectives of this study were to collect and analyze longitudinal clinical data on pulmonary physiology, chest high-resolution CT (HRCT) imaging, and therapies to better delineate the course of disease.
6816. Endothelial function in children with OSA and the effects of adenotonsillectomy.
作者: Kate C C Chan.;Chun T Au.;Ping Chook.;Dennis L Y Lee.;Hugh S Lam.;Yun K Wing.;Albert Martin Li.
来源: Chest. 2015年147卷1期132-139页
The association between childhood OSA and endothelial function as measured by flow-mediated dilation (FMD) and its response to OSA treatment are uncertain. The objective of this study was to compare FMD in children with OSA with nonsnoring control subjects and to examine its response to treatment.
6817. Transbronchial vs transesophageal needle aspiration using an ultrasound bronchoscope for the diagnosis of mediastinal lesions: a randomized study.
作者: Masahide Oki.;Hideo Saka.;Masahiko Ando.;Rie Tsuboi.;Masashi Nakahata.;Saori Oka.;Yoshihito Kogure.;Chiyoe Kitagawa.
来源: Chest. 2015年147卷5期1259-1266页
The purpose of this study was to compare the tolerance, efficacy, and safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) with transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with an endobronchial ultrasound scope for the first pathologic diagnosis of lesions accessible by both procedures.
6818. Association between occupational dust exposure and prognosis of idiopathic pulmonary fibrosis: a Korean national survey.
作者: Sang Hoon Lee.;Dong Soon Kim.;Young Whan Kim.;Man Pyo Chung.;Soo Taek Uh.;Choon Sik Park.;Sung Hwan Jeong.;Yong Bum Park.;Hong Lyeol Lee.;Jeong Sup Song.;Jong Wook Shin.;Nam Soo Yoo.;Eun Joo Lee.;Jin Hwa Lee.;Yangin Jegal.;Hyun Kyung Lee.;Moo Suk Park.
来源: Chest. 2015年147卷2期465-474页
Previous studies have investigated the relationship between occupational and environmental agents and idiopathic pulmonary fibrosis (IPF). However, there have been few studies regarding the prognosis of patients with IPF according to patient occupation.
6819. Health literacy, cognitive function, proper use, and adherence to inhaled asthma controller medications among older adults with asthma.
作者: Rachel O'Conor.;Michael S Wolf.;Samuel G Smith.;Melissa Martynenko.;Daniel P Vicencio.;Mary Sano.;Juan P Wisnivesky.;Alex D Federman.
来源: Chest. 2015年147卷5期1307-1315页
We sought to investigate the degree to which cognitive skills explain associations between health literacy and asthma-related medication use among older adults with asthma.
6820. The MUC5B promoter polymorphism is associated with idiopathic pulmonary fibrosis in a Mexican cohort but is rare among Asian ancestries.
作者: Anna L Peljto.;Moises Selman.;Dong Soon Kim.;Elissa Murphy.;Laura Tucker.;Annie Pardo.;Jung Su Lee.;Wonjun Ji.;Marvin I Schwarz.;Ivana V Yang.;David A Schwartz.;Tasha E Fingerlin.
来源: Chest. 2015年147卷2期460-464页
Polymorphisms in the MUC5B promoter, TOLLIP, and nine additional genetic loci have been associated with idiopathic pulmonary fibrosis (IPF) within non-Hispanic white populations. It is unknown whether these variants account for risk of IPF in other racial/ethnic populations. We conducted a candidate single nucleotide polymorphism (SNP) association study in cohorts of Mexican and Korean patients with IPF.
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