6798. Intradiscal Glucocorticoid Injection for Patients With Chronic Low Back Pain Associated With Active Discopathy: A Randomized Trial.
作者: Christelle Nguyen.;Isabelle Boutron.;Gabriel Baron.;Katherine Sanchez.;Clémence Palazzo.;Raphaël Benchimol.;Guillaume Paris.;Étienne James-Belin.;Marie-Martine Lefèvre-Colau.;Johann Beaudreuil.;Jean-Denis Laredo.;Anne Béra-Louville.;Anne Cotten.;Jean-Luc Drapé.;Antoine Feydy.;Philippe Ravaud.;François Rannou.;Serge Poiraudeau.
来源: Ann Intern Med. 2017年166卷8期547-556页
Active discopathy is associated with a specific phenotype of chronic low back pain (LBP). Local inflammation has a role in active discopathy-associated symptoms.
6799. Oral Direct-Acting Agent Therapy for Hepatitis C Virus Infection: A Systematic Review.
作者: Oluwaseun Falade-Nwulia.;Catalina Suarez-Cuervo.;David R Nelson.;Michael W Fried.;Jodi B Segal.;Mark S Sulkowski.
来源: Ann Intern Med. 2017年166卷9期637-648页
Rapid improvements in hepatitis C virus (HCV) therapy have led to the approval of multiple oral direct-acting antiviral (DAA) regimens by the U.S. Food and Drug Administration (FDA) for treatment of chronic HCV infection.
6800. Clinical Trials of Therapeutics for the Prevention of Congenital Zika Virus Disease: Challenges and Potential Solutions.
作者: Alex P Salam.;Amanda Rojek.;Jake Dunning.;Peter W Horby.
来源: Ann Intern Med. 2017年166卷10期725-732页
Zika virus (ZIKV) infection in pregnancy is associated with adverse fetal outcomes, such as microcephaly and other congenital malformations. No therapeutic options are available to pregnant women with ZIKV infection to prevent these effects. Drug trials in pregnancy raise several scientific, ethical, and logistic challenges, which are compounded further in ZIKV because of limited knowledge of the disease pathophysiology and a product development pipeline in its infancy. We evaluate the major challenges in choosing therapeutics to prevent congenital ZIKV disease and conducting clinical trials of these treatments, with a focus on preventing congenital central nervous system malformations. These challenges must be characterized and planned for now so that clinical trials can progress expediently and effectively in the future.
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