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6761. Ultrasound-guided medical thoracoscopy in the absence of pleural effusion.
作者: Giampietro Marchetti.;Alberto Valsecchi.;Davide Indellicati.;Sabrina Arondi.;Marco Trigiani.;Valentina Pinelli.
来源: Chest. 2015年147卷4期1008-1012页
Medical thoracoscopy (MT) is a diagnostic and therapeutic procedure that permits the study of the pleural space. The presence of pleural adhesions is the most important contraindication to performing MT. Lesions of the pleura in absence of pleural effusion are usually studied in video-assisted thoracoscopic surgery (VATS) with preoperative ultrasound evaluation. No data are available about ultrasound-guided MT in the absence of pleural effusion.
6762. Outcomes after hospitalization in idiopathic pulmonary fibrosis: a cohort study.
作者: A Whitney Brown.;Chelsea P Fischer.;Oksana A Shlobin.;Russell G Buhr.;Shahzad Ahmad.;Nargues A Weir.;Steven D Nathan.
来源: Chest. 2015年147卷1期173-179页
The outcomes of patients with idiopathic pulmonary fibrosis (IPF) who undergo hospitalization have not been well characterized. We sought to determine the frequency of all-cause and respiratory-related hospitalizations and to evaluate their impact on the subsequent course and survival of patients with IPF.
6763. Accuracy of fluorodeoxyglucose-PET imaging for differentiating benign from malignant pleural effusions: a meta-analysis.
作者: José M Porcel.;Paula Hernández.;Montserrat Martínez-Alonso.;Silvia Bielsa.;Antonieta Salud.
来源: Chest. 2015年147卷2期502-512页
The role of fluorodeoxyglucose (FDG)-PET imaging for diagnosing malignant pleural effusions is not well defined. The aim of this study was to summarize the evidence for its use in ruling in or out the malignant origin of a pleural effusion or thickening.
6764. Impact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the Worcester Heart Failure Study.
作者: Kimberly A Fisher.;Mihaela S Stefan.;Chad Darling.;Darleen Lessard.;Robert J Goldberg.
来源: Chest. 2015年147卷3期637-645页
COPD is a common comorbidity in patients with heart failure, yet little is known about the impact of this condition in patients with acute decompensated heart failure (ADHF), especially from a more generalizable, community-based perspective. The primary objective of this study was to describe the in-hospital and postdischarge mortality and treatment of patients hospitalized with ADHF according to COPD status.
6765. Palliative care and location of death in decedents with idiopathic pulmonary fibrosis.
作者: Kathleen O Lindell.;Zhan Liang.;Leslie A Hoffman.;Margaret Q Rosenzweig.;Melissa I Saul.;Joseph M Pilewski.;Kevin F Gibson.;Naftali Kaminski.
来源: Chest. 2015年147卷2期423-429页
Palliative care, integrated early, may reduce symptom burden in patients with idiopathic pulmonary fibrosis (IPF). However, limited information exists on timing and clinical practice. The purpose of this study was to describe the time course of events prior to death in patients with IPF managed at a specialty center with a focus on location of death and timing of referral for palliative care.
6766. Retrospective review of combined sirolimus and simvastatin therapy in lymphangioleiomyomatosis.
作者: Angelo M Taveira-DaSilva.;Amanda M Jones.;Patricia A Julien-Williams.;Mario Stylianou.;Joel Moss.
来源: Chest. 2015年147卷1期180-187页
Combined simvastatin and sirolimus therapy reduces tuberous sclerosis complex 2-null lesions and alveolar destruction in a mouse model of lymphangioleiomyomatosis (LAM), suggesting that therapy with both drugs may benefit patients with LAM.
6767. The impact of lung cancer on survival of idiopathic pulmonary fibrosis.
作者: Sara Tomassetti.;Christian Gurioli.;Jay H Ryu.;Paul A Decker.;Claudia Ravaglia.;Paola Tantalocco.;Matteo Buccioli.;Sara Piciucchi.;Nicola Sverzellati.;Alessandra Dubini.;Giampaolo Gavelli.;Marco Chilosi.;Venerino Poletti.
来源: Chest. 2015年147卷1期157-164页
Lung cancer (LC) is frequently associated with idiopathic pulmonary fibrosis (IPF). Despite this well-known association, the outcome of LC in patients with IPF is unclear. The objective of this study was to evaluate the impact of LC on survival of patients with associated IPF.
6768. Delirium detection using EEG: what and how to measure.
作者: Arendina W van der Kooi.;Irene J Zaal.;Francina A Klijn.;Huiberdina L Koek.;Ronald C Meijer.;Frans S Leijten.;Arjen J Slooter.
来源: Chest. 2015年147卷1期94-101页
Despite its frequency and impact, delirium is poorly recognized in postoperative and critically ill patients. EEG is highly sensitive to delirium but, as currently used, it is not diagnostic. To develop an EEG-based tool for delirium detection with a limited number of electrodes, we determined the optimal electrode derivation and EEG characteristic to discriminate delirium from nondelirium.
6769. Sex differences in response to tadalafil in pulmonary arterial hypertension.
作者: Stephen C Mathai.;Paul M Hassoun.;Milo A Puhan.;Yi Zhou.;Robert A Wise.
来源: Chest. 2015年147卷1期188-197页
Pulmonary arterial hypertension (PAH) is a progressive disease with high rates of morbidity and mortality. Current therapies improve symptoms, functional capacity, and, in select cases, survival. Little is known about patient factors that may predict the likelihood of patient-important, clinically relevant responses to therapy such as the 6-min walk distance (6MWD) and health-related quality of life (HRQoL).
6770. Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study.
作者: William Dalleywater.;Helen A Powell.;Richard B Hubbard.;Vidya Navaratnam.
来源: Chest. 2015年147卷1期150-156页
People with idiopathic pulmonary fibrosis (IPF) have been shown to be at an increased risk for cardiovascular (CV) disease, but reasons for this are unknown. The aim of this study was to compare the prevalence of common CV risk factors in people with IPF and the general population and establish the incidence of ischemic heart disease (IHD) and stroke after the diagnosis of IPF, controlling for these risk factors.
6771. Validation of a scoring system to predict recurrence of resected solitary fibrous tumors of the pleura.
作者: Luis F Tapias.;Olaf Mercier.;Maria R Ghigna.;Benoit Lahon.;Hang Lee.;Douglas J Mathisen.;Philippe Dartevelle.;Michael Lanuti.
来源: Chest. 2015年147卷1期216-223页
Solitary fibrous tumors of the pleura (SFTPs) are infrequent neoplasms with no standardized criteria to predict risk of recurrence after curative surgery. The aim of the present study is to validate a recently proposed recurrence score in a large European cohort of patients with SFTP.
6772. Factors associated with family satisfaction with end-of-life care in the ICU: a systematic review.
Family satisfaction with end-of-life care in the ICU has not previously been systematically reviewed. Our objective was to perform a review, synthesizing published data identifying factors associated with family satisfaction with end-of-life care in critically ill adult populations.
6773. Association between pathogens detected using quantitative polymerase chain reaction with airway inflammation in COPD at stable state and exacerbations.
作者: Bethan L Barker.;Koirobi Haldar.;Hemu Patel.;Ian D Pavord.;Michael R Barer.;Christopher E Brightling.;Mona Bafadhel.
来源: Chest. 2015年147卷1期46-55页
Relationships between airway inflammation and respiratory potentially pathogenic microorganisms (PPMs) quantified using quantitative polymerase chain reaction (qPCR) in subjects with COPD are unclear. Our aim was to evaluate mediators of airway inflammation and their association with PPMs in subjects with COPD at stable state and during exacerbations.
6774. Is a raised bicarbonate, without hypercapnia, part of the physiologic spectrum of obesity-related hypoventilation?
Obesity hypoventilation syndrome (OHS) conventionally includes awake hypercapnia, but an isolated raised bicarbonate, even in the absence of awake hypercapnia, may represent evidence of "early" OHS. We investigated whether such individuals exhibit certain features characteristic of established OHS.
6775. The prognostic value of undetectable highly sensitive cardiac troponin I in patients with acute pulmonary embolism.
作者: Emad U Hakemi.;Tareq Alyousef.;Geetanjali Dang.;Jalal Hakmei.;Rami Doukky.
来源: Chest. 2015年147卷3期685-694页
Elevated cardiac troponin levels have been shown to be associated with adverse outcomes in patients with acute pulmonary embolism (PE). However, few data address the management implications of undetectable cardiac troponin I (cTnI) using a highly sensitive assay. We hypothesized that undetectable cTnI predicts very low in-hospital adverse event rates.
6776. Factors predictive of airflow obstruction among veterans with presumed empirical diagnosis and treatment of COPD.
Despite guideline recommendations, patients suspected of having COPD often are treated empirically instead of undergoing spirometry to confirm airflow obstruction (AFO). Accurate diagnosis and treatment are essential to provide high-quality, value-oriented care. We sought to identify predictors associated with AFO among patients with and treated for COPD prior to performance of confirmatory spirometry.
6777. Would triage predictors perform better than first-come, first-served in pandemic ventilator allocation?
In a pandemic, needs for ventilators might overwhelm the limited supply. Outcome predictors have been proposed to guide ventilator triage allocation decisions. However, pandemic triage predictors have not been validated. This quantitative simulation study evaluated outcomes resulting from allocation strategies varying in their performance for selecting short-stay survivors as favorable candidates for ventilators.
6778. Urinary albumin-creatinine ratio, estimated glomerular filtration rate, and all-cause mortality among US adults with obstructive lung function.
Elevated urinary albumin-creatinine ratio (UACR) and decreased estimated glomerular filtration rate (eGFR) predict all-cause mortality, but whether these markers of kidney damage and function do so in adults with obstructive lung function (OLF) is unclear. The objective of this study was to examine the associations between UACR and eGFR and all-cause mortality in adults with OLF.
6779. Total and state-specific medical and absenteeism costs of COPD among adults aged ≥ 18 years in the United States for 2010 and projections through 2020.
作者: Earl S Ford.;Louise B Murphy.;Olga Khavjou.;Wayne H Giles.;James B Holt.;Janet B Croft.
来源: Chest. 2015年147卷1期31-45页
COPD remains a leading cause of morbidity and mortality. The objectives of this study were to estimate (1) national US COPD-attributable annual medical costs by payer (direct) and absenteeism (indirect) in 2010 and projected medical costs through 2020 and (2) state-specific COPD-attributable medical and absenteeism costs in 2010.
6780. Treatment of alveolar-pleural fistula with endobronchial application of synthetic hydrogel.
作者: Hiren J Mehta.;Paras Malhotra.;Abbie Begnaud.;Andrea M Penley.;Michael A Jantz.
来源: Chest. 2015年147卷3期695-699页
Alveolar-pleural fistula with persistent air leak is a common problem causing significant morbidity, prolonged hospital stay, and increased health-care costs. When conventional therapy fails, an alternative to prolonged chest-tube drainage or surgery is needed. New bronchoscopic techniques have been developed to close the air leak by reducing the flow of air through the leak. The objective of this study was to analyze our experience with bronchoscopic application of a synthetic hydrogel for the treatment of such fistulas.
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