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6729. Understanding why patients with COPD get readmitted: a large national study to delineate the Medicare population for the readmissions penalty expansion.
作者: Tina Shah.;Matthew M Churpek.;Marcelo Coca Perraillon.;R Tamara Konetzka.
来源: Chest. 2015年147卷5期1219-1226页
The Hospital Readmissions Reduction Program (HRRP) penalizes hospitals for 30-day readmissions and was extended to COPD in October 2014. There is limited evidence available on readmission risk factors and reasons for readmission to guide hospitals in initiating programs to reduce COPD readmissions.
6730. Reliability of home respiratory polygraphy for the diagnosis of sleep apnea in children.
作者: María Luz Alonso-Álvarez.;Joaquin Terán-Santos.;Estrella Ordax Carbajo.;José Aurelio Cordero-Guevara.;Ana Isabel Navazo-Egüia.;Leila Kheirandish-Gozal.;David Gozal.
来源: Chest. 2015年147卷4期1020-1028页
The objective of this study was to evaluate the diagnostic reliability of home respiratory polygraphy (HRP) in children with a clinical suspicion of OSA-hypopnea syndrome (OSAS).
6731. Serum Bilirubin and Disease Progression in Mild COPD.
作者: Scott Apperley.;Hye Yun Park.;Daniel T Holmes.;S F Paul Man.;Donald Tashkin.;Robert A Wise.;John E Connett.;Don D Sin.
来源: Chest. 2015年148卷1期169-175页
COPD is a chronic inflammatory disorder associated with oxidative stress. Serum bilirubin has potent antioxidant actions, and higher concentrations have been shown to protect against oxidative stress. The relation between serum bilirubin and COPD progression is unknown.
6732. Exome sequencing identifies mutant TINF2 in a family with pulmonary fibrosis.
作者: Jonathan K Alder.;Susan E Stanley.;Christa L Wagner.;Makenzie Hamilton.;Vidya Sagar Hanumanthu.;Mary Armanios.
来源: Chest. 2015年147卷5期1361-1368页
Short telomeres are a common defect in idiopathic pulmonary fibrosis, yet mutations in the telomerase genes account for only a subset of these cases.
6733. Natural history of typical pulmonary carcinoid tumors: a comparison of nonsurgical and surgical treatment.
The natural history of typical pulmonary carcinoid tumors has not been described and has important implications for counseling elderly patients or patients with high operative-risk about surgical resection.
6734. How Common Is Airflow Limitation in Patients With Emphysema on CT Scan of the Chest?
作者: Sanjiva M Lutchmedial.;Whitney G Creed.;Alastair J Moore.;Ryan R Walsh.;George E Gentchos.;David A Kaminsky.
来源: Chest. 2015年148卷1期176-184页
COPD has traditionally been defined by the presence of irreversible airflow limitation on spirometry using either the GOLD (Global Initiative for Chronic Obstructive Lung Disease) or American Thoracic Society/European Respiratory Society criteria (lower limit of normal [LLN]). We have observed that some patients with clinical COPD and emphysema on chest CT scan have no obstruction on spirometry. The purpose of this study was to assess the prevalence of obstruction by GOLD and LLN criteria in patients with emphysema on CT scan and determine which radiographic criteria were associated with a clinical diagnosis of COPD.
6737. Tools for assessing outcomes in studies of chronic cough: CHEST guideline and expert panel report.
作者: Louis-Philippe Boulet.;Remy R Coeytaux.;Douglas C McCrory.;Cynthia T French.;Anne B Chang.;Surinder S Birring.;Jaclyn Smith.;Rebecca L Diekemper.;Bruce Rubin.;Richard S Irwin.; .
来源: Chest. 2015年147卷3期804-814页
Since the publication of the 2006 American College of Chest Physicians (CHEST) cough guidelines, a variety of tools has been developed or further refined for assessing cough. The purpose of the present committee was to evaluate instruments used by investigators performing clinical research on chronic cough. The specific aims were to (1) assess the performance of tools designed to measure cough frequency, severity, and impact in adults, adolescents, and children with chronic cough and (2) make recommendations or suggestions related to these findings.
6739. Chemoreceptor Responsiveness at Sea Level Does Not Predict the Pulmonary Pressure Response to High Altitude.
作者: Ryan L Hoiland.;Glen E Foster.;Joseph Donnelly.;Mike Stembridge.;Chris K Willie.;Kurt J Smith.;Nia C Lewis.;Samuel J E Lucas.;Jim D Cotter.;David J Yeoman.;Kate N Thomas.;Trevor A Day.;Mike M Tymko.;Keith R Burgess.;Philip N Ainslie.
来源: Chest. 2015年148卷1期219-225页
The hypoxic ventilatory response (HVR) at sea level (SL) is moderately predictive of the change in pulmonary artery systolic pressure (PASP) to acute normobaric hypoxia. However, because of progressive changes in the chemoreflex control of breathing and acid-base balance at high altitude (HA), HVR at SL may not predict PASP at HA. We hypothesized that resting oxygen saturation as measured by pulse oximetry (Spo₂) at HA would correlate better than HVR at SL with PASP at HA.
6740. Children with chronic cough: when is watchful waiting appropriate? development of likelihood ratios for assessing children with chronic cough.
作者: Anne B Chang.;Peter P Van Asperen.;Nicholas Glasgow.;Colin F Robertson.;Craig M Mellis.;I Brent Masters.;Louis I Landau.;Laurel Teoh.;Irene Tjhung.;Helen L Petsky.;Peter S Morris.
来源: Chest. 2015年147卷3期745-753页
Chronic cough is associated with poor quality of life and may signify a serious underlying disease. Differentiating nonspecific cough (when watchful waiting can be safely undertaken) from specific cough (treatment and further investigations are beneficial) would be clinically useful. In 326 children, we aimed to (1) determine how well cough pointers (used in guidelines) differentiate specific from nonspecific cough and (2) describe the clinical profile of children whose cough resolved without medications (spontaneous resolution).
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