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6641. Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD.
作者: Joseph Footitt.;Patrick Mallia.;Andrew L Durham.;W Eugene Ho.;Maria-Belen Trujillo-Torralbo.;Aurica G Telcian.;Ajerico Del Rosario.;Cheng Chang.;Hong-Yong Peh.;Tatiana Kebadze.;Julia Aniscenko.;Luminita Stanciu.;Sarah Essilfie-Quaye.;Kazuhiro Ito.;Peter J Barnes.;Sarah L Elkin.;Onn M Kon.;W S Fred Wong.;Ian M Adcock.;Sebastian L Johnston.
来源: Chest. 2016年149卷1期62-73页
Respiratory virus infections are commonly associated with COPD exacerbations, but little is known about the mechanisms linking virus infection to exacerbations. Pathogenic mechanisms in stable COPD include oxidative and nitrosative stress and reduced activity of histone deacetylase-2 (HDAC2), but their roles in COPD exacerbations is unknown. We investigated oxidative and nitrosative stress (O&NS) and HDAC2 in COPD exacerbations using experimental rhinovirus infection.
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