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621. FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer.
作者: Marta Canel.;Aleksandra Dominika Sławińska.;David W Lonergan.;Ashwin Adrian Kallor.;Rosie Upstill-Goddard.;Catherine Davidson.;Alex von Kriegsheim.;Andrew V Biankin.;Adam Byron.;Javier Alfaro.;Alan Serrels.
来源: Gut. 2023年73卷1期131-155页
Immunotherapy for the treatment of pancreatic ductal adenocarcinoma (PDAC) has shown limited efficacy. Poor CD8 T-cell infiltration, low neoantigen load and a highly immunosuppressive tumour microenvironment contribute to this lack of response. Here, we aimed to further investigate the immunoregulatory function of focal adhesion kinase (FAK) in PDAC, with specific emphasis on regulation of the type-II interferon response that is critical in promoting T-cell tumour recognition and effective immunosurveillance.
622. NNMT enriches for AQP5+ cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma.
作者: Zhangding Wang.;Qiang Wang.;Chen Chen.;Xiaoya Zhao.;Honggang Wang.;Lei Xu.;Yao Fu.;Guang Huang.;Mengmeng Li.;Jiawen Xu.;Qianyi Zhang.;Bo Wang.;Guifang Xu.;Lei Wang.;Xiaoping Zou.;Shouyu Wang.
来源: Gut. 2023年73卷1期63-77页
Early gastric cardia adenocarcinoma (EGCA) is a highly heterogeneous cancer, and the understanding of its classification and malignant progression is limited. This study explored the cellular and molecular heterogeneity in EGCA using single-cell RNA sequencing (scRNA-seq).
623. Three double-dose reinforced hepatitis B revaccination scheme for patients with cirrhosis unresponsive to the standard regimen: an open-label randomised clinical trial.
作者: Álvaro Giráldez-Gallego.;Elisa Del Pilar Rodríguez-Seguel.;Raquel Valencia-Martín.;Áurea Morillo-García.;Celia Salamanca-Rivera.;Ricardo Ruiz-Pérez.;María Cuaresma-Duque.;Clara Rosso-Fernández.;María Teresa Ferrer-Ríos.;José Manuel Sousa-Martín.;Juan Manuel Praena-Fernández.;Trinidad Desongles-Corrales.;Aitana Rodríguez-Pérez.;Francisco Camino-Durán.;Antonia Gasch-Illescas.;Javier Ampuero-Herrojo.;Juan Manuel Pascasio-Acevedo.
来源: Gut. 2023年73卷1期166-174页
We aimed to compare the response rates between two different hepatitis B virus vaccination schedules for cirrhotic subjects who were non-responders to the first three 40 µg doses (month 0-1-2), and identify factors associated with the final response.
624. Faecal metabolome and its determinants in inflammatory bowel disease.
作者: Arnau Vich Vila.;Shixian Hu.;Sergio Andreu-Sánchez.;Valerie Collij.;Bernadien H Jansen.;Hannah E Augustijn.;Laura A Bolte.;Renate A A A Ruigrok.;Galeb Abu-Ali.;Cosmas Giallourakis.;Jessica Schneider.;John Parkinson.;Amal Al-Garawi.;Alexandra Zhernakova.;Ranko Gacesa.;Jingyuan Fu.;Rinse K Weersma.
来源: Gut. 2023年72卷8期1472-1485页
Inflammatory bowel disease (IBD) is a multifactorial immune-mediated inflammatory disease of the intestine, comprising Crohn's disease and ulcerative colitis. By characterising metabolites in faeces, combined with faecal metagenomics, host genetics and clinical characteristics, we aimed to unravel metabolic alterations in IBD.
625. A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut.
作者: Sidharth P Mishra.;Bo Wang.;Shalini Jain.;Jingzhong Ding.;Jared Rejeski.;Cristina M Furdui.;Dalane W Kitzman.;Subhash Taraphder.;Christian Brechot.;Ambuj Kumar.;Hariom Yadav.
来源: Gut. 2023年72卷10期1848-1865页
Ample evidence exists for the role of abnormal gut microbiota composition and increased gut permeability ('leaky gut') in chronic inflammation that commonly co-occurs in the gut in both obesity and diabetes, yet the detailed mechanisms involved in this process have remained elusive.
628. Australian inflammatory bowel disease consensus statements for preconception, pregnancy and breast feeding.
作者: Robyn Laube.;Christian P Selinger.;Cynthia H Seow.;Britt Christensen.;Emma Flanagan.;Debra Kennedy.;Reme Mountifield.;Sean Seeho.;Antonia Shand.;Astrid-Jane Williams.;Rupert W Leong.
来源: Gut. 2023年72卷6期1040-1053页
Because pregnancy outcomes tend to be worse in women with inflammatory bowel disease (IBD) than in those without, we aimed to update consensus statements that guide the clinical management of pregnancy in patients with IBD.
630. Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.
作者: Chang Xu.;Kie Kyon Huang.;Jia Hao Law.;Joy Shijia Chua.;Taotao Sheng.;Natasha M Flores.;Melissa Pool Pizzi.;Atsushi Okabe.;Angie Lay Keng Tan.;Feng Zhu.;Vikrant Kumar.;Xiaoyin Lu.;Ana Morales Benitez.;Benedict Shi Xiang Lian.;Haoran Ma.;Shamaine Wei Ting Ho.;Kalpana Ramnarayanan.;Chukwuemeka George Anene-Nzelu.;Milad Razavi-Mohseni.;Siti Aishah Binte Abdul Ghani.;Su Ting Tay.;Xuewen Ong.;Ming Hui Lee.;Yu Amanda Guo.;Hassan Ashktorab.;Duane Smoot.;Shang Li.;Anders Jacobsen Skanderup.;Michael A Beer.;Roger Sik Yin Foo.;Joel Shi Hao Wong.;Kaushal Sanghvi.;Wei Peng Yong.;Raghav Sundar.;Atsushi Kaneda.;Shyam Prabhakar.;Pawel Karol Mazur.;Jaffer A Ajani.;Khay Guan Yeoh.;Jimmy Bok-Yan So.;Patrick Tan.; .
来源: Gut. 2023年72卷9期1651-1663页
Gastric cancer (GC) is a leading cause of cancer mortality, with ARID1A being the second most frequently mutated driver gene in GC. We sought to decipher ARID1A-specific GC regulatory networks and examine therapeutic vulnerabilities arising from ARID1A loss.
633. Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer.
作者: Feda H Hamdan.;Amro M Abdelrahman.;Ana Patricia Kutschat.;Xin Wang.;Thomas L Ekstrom.;Nidhi Jalan-Sakrikar.;Catherine Wegner Wippel.;Negar Taheri.;Liezel Tamon.;Waltraut Kopp.;Joana Aggrey-Fynn.;Aditya V Bhagwate.;Roberto Alva-Ruiz.;Isaac Lynch.;Jennifer Yonkus.;Robyn Laura Kosinsky.;Jochen Gaedcke.;Stephan A Hahn.;Jens T Siveke.;Rondell Graham.;Zeynab Najafova.;Elisabeth Hessmann.;Mark J Truty.;Steven A Johnsen.
来源: Gut. 2023年72卷6期1174-1185页
Pancreatic ductal adenocarcinoma (PDAC) displays a remarkable propensity towards therapy resistance. However, molecular epigenetic and transcriptional mechanisms enabling this are poorly understood. In this study, we aimed to identify novel mechanistic approaches to overcome or prevent resistance in PDAC.
634. SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer.
作者: Raphael Rapetti-Mauss.;Jérémy Nigri.;Camille Berenguier.;Pascal Finetti.;Sarah Simha Tubiana.;Bonnie Labrum.;Benoit Allegrini.;Bernard Pellissier.;Georgios Efthymiou.;Zainab Hussain.;Corinne Bousquet.;Nelson Dusetti.;François Bertucci.;Hélène Guizouarn.;Patricia Melnyk.;Franck Borgese.;Richard Tomasini.;Olivier Soriani.
来源: Gut. 2023年72卷4期722-735页
Intercellular communication within pancreatic ductal adenocarcinoma (PDAC) dramatically contributes to metastatic processes. The underlying mechanisms are poorly understood, resulting in a lack of targeted therapy to counteract stromal-induced cancer cell aggressiveness. Here, we investigated whether ion channels, which remain understudied in cancer biology, contribute to intercellular communication in PDAC.
635. 'Family-based' strategy for Helicobacter pylori infection screening: an efficient alternative to 'test and treat' strategy.
作者: Jiafeng Zhang.;Yuchen Deng.;Chang Liu.;Huiquan Wang.;Heifei Ren.;Sai Chen.;Lei Chen.;Bin Shi.;Lin Zhou.
来源: Gut. 2024年73卷4期709-712页 637. Gnotobiotic mice housing conditions critically influence the phenotype associated with transfer of faecal microbiota in a context of obesity.
作者: Laurence Daoust.;Béatrice S-Y Choi.;Anne-Laure Agrinier.;Thibault V Varin.;Adia Ouellette.;Patricia L Mitchell.;Nolwenn Samson.;Genevieve Pilon.;Emile Levy.;Yves Desjardins.;Mathieu Laplante.;Fernando F Anhê.;Vanessa P Houde.;Andre Marette.
来源: Gut. 2023年72卷5期896-905页
Faecal microbiota transplantation (FMT) in germ-free (GF) mice is a common approach to study the causal role of the gut microbiota in metabolic diseases. Lack of consideration of housing conditions post-FMT may contribute to study heterogeneity. We compared the impact of two housing strategies on the metabolic outcomes of GF mice colonised by gut microbiota from mice treated with a known gut modulator (cranberry proanthocyanidins (PAC)) or vehicle.
638. Robust SARS-CoV-2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments.
作者: Eva Zhang.;Thi H O Nguyen.;Lilith F Allen.;Lukasz Kedzierski.;Louise C Rowntree.;So Young Chang.;Wuji Zhang.;Jennifer R Habel.;Isabelle J Foo.;Tejas Menon.;Jeni Mitchell.;Rupert W Leong.;Katherine Bond.;Deborah A Williamson.;Katherine Kedzierska.;Britt Christensen.
来源: Gut. 2024年73卷4期712-714页 639. Sucrase-isomaltase genotype and response to a starch-reduced and sucrose-reduced diet in IBS-D patients.
作者: Andreea Zamfir-Taranu.;Britt-Sabina Löscher.;Diab M Husein.;Abdullah Hoter.;Koldo Garcia-Etxebarria.;Usune Etxeberria.;Lucía Gayoso.;Gabriele Mayr.;Clara Nilholm.;Rita J Gustafsson.;Oliver Ozaydin.;Tenghao Zheng.;Cristina Esteban-Blanco.;Isotta Bozzarelli.;Ferdinando Bonfiglio.;Sandra Rizk.;Andre Franke.;Luis Bujanda.;Hassan Y Naim.;Bodil Ohlsson.;Mauro D'Amato.
来源: Gut. 2024年73卷4期706-708页 640. Empiric use of standard triple therapy in Helicobacter pylori eradication does not require readjustment in the clarithromycin resistance cut-off point.
作者: Peter Malfertheiner.;Francis Megraud.;Theodore Rokkas.;Javier P Gisbert.
来源: Gut. 2024年73卷4期708-709页 |