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501. Addressing clinical challenges in ANCA-associated vasculitis with real-world evidence.
Key challenges in the management of ANCA-associated vasculitis (AAV) include the need to achieve more rapid and sustained remission, reduce exposure to glucocorticoids (GC) and reliably monitor and predict treatment response. Clinical trials in patients receiving rituximab or cyclophosphamide for AAV show that the adjunctive use of avacopan (a novel complement 5a receptor 1 [C5aR1] antagonist) for up to 1 year enables sustained AAV remission, considerable reductions in GC exposure, and greater recovery of kidney function, especially in patients with acute kidney injury. Additional real-world evidence suggests avacopan can be used to replace GC in patients with GC toxicity and supports the use of avacopan in AAV patients with rapidly progressing glomerulonephritis, pulmonary hemorrhage and/or refractory AAV. Future studies are needed to investigate the benefits of extending avacopan treatment beyond 1 year and in specific populations.
503. Impact of HLA-DRB1 SE, anti-citrullinated protein antibodies and smoking on radiographic outcome in Greek patients with Rheumatoid Arthritis.
作者: Evangelia N Mole.;Katerina Tarassi.;Alexandra Tsirogianni.;Theophilos Athanassiades.;Vasiliki Kitsiou.;Diamanto Kouniaki.;Sousana Gazi.;Panagiotis Vlachoyiannopoulos.
来源: BMC Rheumatol. 2025年9卷1期128页
Rheumatoid arthritis (RA) is a complex, multifactorial autoimmune disease, whose aetiopathogenesis involves genetic and environmental factors. It remains unclear whether these factors influence the radiographic damage in RA patients. In this study we aimed to investigate the main effects of shared epitope (SE) alleles, smoking and anti-citrullinated protein antibodies (ACPAs), as well as their possible interaction on the radiographic outcome, in Greek patients with longstanding RA.
504. Gastrointestinal involvement in granulomatosis with polyangiitis: frequency, clinical impact, and prognostic implications in a retrospective cohort study.
作者: Goli Siri.;Seyed Farshad Allameh.;Mahsa Heidari-Foroozan.;Abdolreza Raee.;Mohammad Sadidi.;Mahgol Meshkati.
来源: BMC Rheumatol. 2025年9卷1期129页
Granulomatosis with polyangiitis (GPA) is a rare form of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis that can involve multiple organ systems, including the gastrointestinal (GI) tract. Although GI manifestations are relatively uncommon, they may be associated with serious complications and adverse outcomes. This study aimed to assess the frequency and types of GI involvement in patients with GPA and to examine their relationship with disease severity, prognosis, and treatment response.
505. Fetal and maternal outcome in the pregnancies of patients with systemic sclerosis and very early diagnosis of systemic sclerosis in France: a prospective study.
作者: Anne Murarasu.;Lauren Beaudeau.;Veronique Le Guern.;Gaelle Guettrot-Imbert.;Claire Cazalets.;Cécile Durant.;Cécile Yelnik.;Céline Lartigau Roussin.;Marie-Charlotte Besse.;Emilie Berthoux.;Emmanuel Chatelus.;Eric Hachulla.;Estibaliz Lazaro.;Francois Maurier.;Gaëlle Leroux.;Gregory Pugnet.;Isabelle Durieu.;Loic Raffray.;Maelle Le Besnerais.;Mélanie Roriz.;Odile Souchaud Debouverie.;Patrick Jego.;Pauline Orquevaux.;Claire De Moreuil.;Helene Maillard.;Nathalie Morel.;Anna Molto.;Camille Le Ray.;Emmanuelle Pannier.;Loïc Sentilhes.;Luc Mouthon.;Nathalie Costedoat-Chalumeau.;Benjamin Chaigne.; .
来源: Lancet Rheumatol. 2026年8卷1期e33-e41页
Prospective data on pregnancies in systemic sclerosis are scarce. We aimed to examine the frequency of adverse pregnancy outcomes and maternal disease progression in systemic sclerosis, as well as the factors that predict these events.
508. Lupus enteritis and peritonitis as a first presentation of systemic lupus erythematosus: a case report.
作者: Bashar Kamal Ali Douden.;Nouraldin Hashlamon.;Mahmoud Al-Zaro.;Mahmood Fayiz Ali Al-Drabeeh.;Mohammad Halayqa.;Sufyan Hroub.;Saed Atawnah.
来源: BMC Rheumatol. 2025年9卷1期127页
SLE is a chronic autoimmune illness that affects several systems. Gastrointestinal abnormalities, although uncommon, can be dangerous and frequently go undiagnosed due to vague symptoms. Lupus enteritis and peritonitis are serious consequences. Lupus enteritis affects up to 9.7% of SLE patients and causes stomach discomfort, nausea, and diarrhea. It frequently involves intestinal vasculitis, which results in gut wall thickening and, in extreme instances, ischemia or perforation. Lupus peritonitis is very uncommon. Differentiating them from other causes of stomach discomfort is critical. This case emphasizes the diagnostic problems, imaging results, and the significance of early, focused therapy for better outcomes.
511. Incidence and risk of nephrolithiasis with uricosuric therapies for the treatment of gout: a systematic review and meta-analysis of randomized controlled trials and cohort studies.
作者: Chanaka Dahanayake.;Ram Bajpai.;Mark Lambie.;Kelsey M Jordan.;Edward Roddy.
来源: Rheumatology (Oxford). 2026年65卷2期
To assess the incidence and risk of nephrolithiasis in people receiving uricosuric therapies for gout.
512. Comparable 12-month renal response outcomes with medium- vs high-dose starting prednisone in a real-world study of Lupus Nephritis.
作者: Maria Pappa.;Sofia Flouda.;Antigone Pieta.;Spyridon Katechis.;Myrto Nikoloudaki.;Nektarios-Marios Liapis.;Christina Tsalapaki.;Aglaia Chalkia.;Evangelia Argyriou.;Theodoros Dimitroulas.;Myrto Cheila.;Charalampos Papagoras.;Andreas V Goules.;Christina Katsiari.;Dimitrios Vassilopoulos.;Prodromos Sidiropoulos.;Kyriaki A Boki.;Petros P Sfikakis.;George Liapis.;Charikleia Gakiopoulou.;Foteini Karasavvidou.;Paraskevi V Voulgari.;Dimitrios Boumpas.;George K Bertsias.;Maria G Tektonidou.;Antonis Fanouriakis.
来源: Rheumatology (Oxford). 2026年65卷2期
The optimal starting dose and tapering of glucocorticoids (GC) in LN remains unknown. We aimed to assess whether a higher prednisone dose results in better 12-month complete renal response (CRR) rates compared with a lower dose, in a contemporary multicentre cohort of LN patients.
513. Sexual function in axial spondyloarthritis: a systematic review and meta-analysis.
作者: Max Somer.;Simone Battista.;Jake Grange.;Yeliz Prior.;Helen Parsons.;Jonathan Packham.;Kirstie L Haywood.;Benedetto Giardulli.;James A Prior.
来源: Rheumatology (Oxford). 2026年65卷2期
This systematic review and meta-analysis examined how axial spondyloarthritis (axSpA), and its specific disease features, impact sexual function.
514. Evaluation of a web-based self-monitoring application (MyRA) to empower people with rheumatoid arthritis in daily life.
作者: Laura M J Hochstenbach.;Joost G E Verbeek.;Maria B J Brokken-Peters.;Pim van den Dungen.;Anouk M Knops.;Marieke D Spreeuwenberg.;Harald E Vonkeman.;Astrid van Tubergen.
来源: Rheumatology (Oxford). 2026年65卷2期
To evaluate MyRA, a web-based self-monitoring application for RA, on patient empowerment, usability and perceived usefulness.
515. Distinct expression profiles of inflammasome-associated genes in systemic juvenile idiopathic arthritis.
作者: Masaki Shimizu.;Shuya Kaneko.;Asami Shimbo.;Maho Hatano.;Futaba Miyaoka.;Yuko Hayashi.;Hitoshi Irabu.;Yuko Akutsu.;Masaaki Mori.
来源: Rheumatology (Oxford). 2026年65卷2期
This study aimed to clarify the activation profile of inflammasome-associated genes in systemic JIA (s-JIA).
516. Clinical significance of non-infectious procalcitonin elevation in Still's disease: a predictor of macrophage activation syndrome.
作者: Erdem Bektas.;Burcu Ceren Uludogan.;Busra Firlatan Yazgan.;Ozgur Can Kilinc.;Beste Acar.;Oguzhan Kizilkaya.;Aysenur Yilmaz.;Busra Yuce.;Reside Borce Aydin.;Meliha Meric Koc.;Serdal Ugurlu.;Umut Kalyoncu.;Timucin Kasifoğlu.;Cemal Bes.
来源: Rheumatology (Oxford). 2026年65卷2期
Still's disease (SD) is an autoinflammatory disease (AID) that can lead to life-threatening macrophage activation syndrome (MAS). The role of procalcitonin (PCT) in AIDs remains unclear. This study aims to explore the relationship between non-infectious PCT elevation and clinical features of SD.
518. Risk of hospitalization with pneumonia in patients with giant cell arteritis and anti-neutrophil cytoplasmic antibody associated vasculitis.
作者: Mads E R Sørensen.;René Cordtz.;Kirsten S Duch.;Maria Stilling-Vinther.;Lene Dreyer.;Karina F Kirk.;Mette Holland-Fischer.;Salome Kristensen.
来源: Rheumatology (Oxford). 2026年65卷2期
This study aimed to assess the risk of hospitalization with pneumonia (HP) among patients with GCA and ANCA associated vasculitis (AAV).
519. Clinical and molecular characterization of ILD in patients with overlapping ASyS and SjD: a retrospective observational study.
作者: Yulu Qiu.;Chengyin Lv.;Yue Wang.;Hanxiao You.;Qi Wang.;Fang Wang.;Wenfeng Tan.;Yujing Zhu.
来源: Rheumatology (Oxford). 2026年65卷2期
Interstitial lung disease (ILD) is a frequent complication in both anti-synthetase syndrome (ASyS) and primary Sjögren's disease (pSjD), but the clinical and molecular phenotype of patients with overlapping ASyS and pSjD (ASyS-SjD) remains poorly defined. This study aimed to characterize the clinical, serological, radiological and transcriptomic features of ASyS-SjD patients with ILD, and to determine whether this overlap represents a distinct disease entity.
520. Clinical efficacy of JAK inhibitors for RA patients with poor-prognosis factors: the ANSWER cohort study.
作者: Yuji Nozaki.;Koichi Murata.;Akira Onishi.;Kohei Tsujimoto.;Wataru Yamamoto.;Hirotaka Yamada.;Sho Sendo.;Motomu Hashimoto.;Tadashi Okano.;Hideyuki Shiba.;Yuri Hiramatsu.;Yonsu Son.;Naofumi Yoshida.;Rika Fukuda.;Yumi Morimoto.;Kazuya Kishimoto.;Tetsu Itami.;Daisuke Tomita.;Chisato Ashida.;Toshihiko Shiga.;Koji Kinoshita.
来源: Rheumatology (Oxford). 2026年65卷1期
We evaluated the efficacy of Janus kinase inhibitors (JAKis) compared with TNF inhibitors (TNFis) in RA patients with poor-prognosis factors (PPFs), including ACPA or RF positivity, Clinical Disease Activity Index (CDAI) ≥22, CRP ≥0.6 mg/dl and HAQ-DI ≥0.5. We focused on treatment continuation, disease control and glucocorticoid (GC) reduction.
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