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481. Heart Rate Reduction Is Associated With Reverse Left Ventricular Remodeling and Mechanism-Specific Molecular Phenotypes in Dilated Cardiomyopathy.
作者: Natasha L Altman.;Edward A Gill.;Rami Kahwash.;Leslie K Meyer.;Jessica A Wagner.;Anis Karimpour-Fard.;Amber A Berning.;Wayne A Minobe.;Ian A Carroll.;Eric R Jonas.;Dobromir Slavov.;Sitaramesh Emani.;William T Abraham.;Alexa R Gollah.;Samuel L Ellis.;Matthew R G Taylor.;Sharon L Graw.;Luisa Mestroni.;Timothy A McKinsey.;Peter M Buttrick.;David P Kao.;Michael R Bristow.
来源: Circ Heart Fail. 2025年18卷4期e012484页
Heart rate (HR) affects heart failure outcomes, via uncertain mechanisms that may include left ventricular remodeling. However, in human ventricular myocardium, HR change has not been associated with a particular remodeling molecular phenotype.
482. Hemodynamics of Exercise-Induced Hypertension and Relationship to Outcomes in Adults With Coarctation of the Aorta.
作者: Alexander C Egbe.;Yogesh N V Reddy.;William R Miranda.;C Charles Jain.;Heidi M Connolly.;Barry A Borlaug.
来源: Circ Heart Fail. 2025年18卷4期e012459页
Exercise-induced hypertension (EIH) is common in adults with coarctation of the aorta (COA), but there are limited data about hemodynamics and outcomes in such patients. The purpose of this study was to assess changes in arterial load during exercise in patients with COA with versus without EIH, and the relationship to clinical outcomes.
483. Transfer to Hub Hospitals and Outcomes in Cardiogenic Shock.
作者: Shubhadarshini Pawar.;Kannu Bansal.;J Dawn Abbott.;Manreet K Kanwar.;Navin K Kapur.;Van-Khue Ton.;Saraschandra Vallabhajosyula.
来源: Circ Heart Fail. 2025年18卷4期e012477页
There are limited large-scale data on the outcomes of patients with cardiogenic shock (CS) transferred to hub centers. This study aimed to compare the characteristics and outcomes of transferred patients with CS versus those who were not transferred.
485. Early Versus Delayed Invasive Management of Female Patients With Non-ST-Elevation Acute Coronary Syndrome: An Individual Patient Data Meta-Analysis.
作者: Gregory B Mills.;Christos P Kotanidis.;Shamir Mehta.;Denise Tiong.;Erik A Badings.;Thomas Engstrøm.;Arnoud W J van 't Hof.;Dan Høfsten.;Lene Holmvang.;Alexander Jobs.;Lars Køber.;Dejan Milasinovic.;Aleksandra Milosevic.;Goran Stankovic.;Holger Thiele.;Roxana Mehran.;Vijay Kunadian.
来源: Circ Cardiovasc Interv. 2025年18卷3期e014763页
Female patients are at greater risk of adverse events following non-ST-elevation acute coronary syndrome but less frequently receive guideline-recommended coronary angiography and revascularization. Routine invasive management benefits high-risk patients, but evidence informing the optimal timing of angiography specifically in female patients is lacking.
486. Recurrent Cryptogenic Ischemic Strokes in a Young Female Patient: A Case of a Bilateral Carotid Web.
作者: Erica Rocco.;Marco Ciacciarelli.;Salvino Bilancini.;Sonia Ferri.;Alessandro Polidoro.;Marco Rengo.;Beatrice Simeone.;Valentina Valenti.;Sebastiano Sciarretta.;Luigi Iuliano.
来源: Circ Cardiovasc Imaging. 2025年e017819页 488. Targeting uPARAP Modifies Lymphatic Vessel Architecture and Attenuates Lymphedema.
作者: Fabrice Gucciardo.;Alizée Lebeau.;Sébastien Pirson.;Florence Buntinx.;Elitsa Ivanova.;Silvia Blacher.;Pascal Brouillard.;Jonathan Deroye.;Louis Baudin.;Alexandra Pirnay.;Florent Morfoisse.;Claire Villette.;Christophe Nizet.;François Lallemand.;Carine Munaut.;Kari Alitalo.;Liesbet Geris.;Miikka Vikkula.;Marine Gautier-Isola.;Agnès Noel.
来源: Circulation. 2025年151卷19期1412-1429页
Lymphedema is an incurable disease associated with lymphatic dysfunction that causes tissue swelling and fibrosis. We investigated whether lymphedema could be attenuated by interfering with uPARAP (urokinase plasminogen activator receptor-associated protein; Mrc2 gene), an endocytic receptor involved in fibrosis and lymphangiogenesis.
489. Endomyocardial Fibrosis Mimicking a Heart Tumor and Dysplastic Tricuspid Valve in a Teenager: A Rare Cardiac Manifestation of Behçet Disease.
作者: Francesca Sperotto.;Pakaparn Kittichokechai.;Andrew J Powell.;Tal Geva.;Naomi Gauthier.;Joyce C Chang.;Brian D Soriano.;Nikhil Thatte.
来源: Circ Cardiovasc Imaging. 2025年e017064页 495. Echocardiographic Characterization of Myocardial Stiffness in Healthy Volunteers, Cardiac Amyloidosis, and Hypertrophic Cardiomyopathy: A Case-Control Study Using Multimodality Imaging.
作者: Dominik C Benz.;Ali Sadeghi.;Pat G Rafter.;Olivier F Clerc.;Jocelyn Canseco Neri.;Alexandra Taylor.;Shilpa Vijayakumar.;Carolyn Y Ho.;Sarah A M Cuddy.;Rodney H Falk.;Sharmila Dorbala.
来源: Circ Cardiovasc Imaging. 2025年18卷3期e017475页
Noninvasive tools to measure myocardial stiffness are limited. Intrinsic cardiac elastography in echocardiography relates to myocardial stiffness by measuring the propagation of the myocardial stretch generated by atrial contraction. The aims of the present study were (1) to evaluate myocardial stiffness using intrinsic cardiac elastography in healthy volunteers versus those with myocardial diseases (ie, cardiac amyloidosis [CA] and hypertrophic cardiomyopathy) and (2) to identify key factors that affect myocardial stiffness.
498. Race- and Sex-Specific Age at Which Coronary Artery Calcium Becomes Detectable Among Young Adults.
作者: Yvette A Yeboah-Kordieh.;Ellen Boakye.;Albert D Osei.;Omar Dzaye.;Zeina A Dardari.;Joao A C Lima.;Alan Rozanski.;Daniel S Berman.;Matthew J Budoff.;Michael D Miedema.;Khurram Nasir.;John A Rumberger.;Leslee J Shaw.;David R Jacobs.;Michael J Blaha.
来源: Circ Cardiovasc Imaging. 2025年18卷3期e016599页
Coronary artery calcium (CAC) is an excellent predictor of atherosclerotic cardiovascular disease (ASCVD) risk. Limited data exist on the age at which CAC transitions to nonzero among young adults. We aimed to assess the prevalence of CAC by the number of ASCVD risk factors and use this data to model the race- and sex-specific ages at which young adults transition to a CAC >0.
500. Association Between Use of WATCHMAN Device and 1-Year Mortality Using High-Dimensional Propensity Scores to Reduce Confounding.
作者: Julie Z Zhao.;Mohammed Ruzieh.;Fanxing Du.;Yi Lian.;Andrew J Foy.;Robert W Platt.;Mark S Segal.;Janie Coulombe.;Almut G Winterstein.;Tianze Jiao.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷4期e011188页
Previous observational studies showed left atrial appendage occlusions with the WATCHMAN device reduced 1-year mortality, which conflicted with evidence generated from randomized controlled trials. We proposed to use the high-dimensional propensity score (hdPS) to assist in nonactive comparator selection (prevalent user of medication) and compared 1-year mortality between patients with atrial fibrillation who received the WATCHMAN device (percutaneous left atrial appendage occlusion device [pLAAO]) and direct oral anticoagulants in 2 matched cohorts based on (1) traditional propensity score (PS) and (2) integrating traditional PS with information learned from hdPS.
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