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4961. Prevalence, Recognition of Work-Relatedness, and Effect on Work of Low Back Pain Among U.S. Workers.
作者: Sara E Luckhaupt.;James M Dahlhamer.;Gabriella T Gonzales.;Ming-Lun Lu.;Matthew Groenewold.;Marie Haring Sweeney.;Brian W Ward.
来源: Ann Intern Med. 2019年171卷4期301-304页
This is the prepublication, author-produced version of a manuscript accepted for publication in Annals of Internal Medicine. This version does not include post-acceptance editing and formatting. The American College of Physicians, the publisher of Annals of Internal Medicine, is not responsible for the content or presentation of the author-produced accepted version of the manuscript or any version that a third party derives from it. Readers who wish to access the definitive published version of this manuscript and any ancillary material related to this manuscript (e.g., correspondence, corrections, editorials, linked articles) should go to Annals.org or to the print issue in which the article appears. Those who cite this manuscript should cite the published version, as it is the official version of record.
4962. Performance of the T2Bacteria Panel for Diagnosing Bloodstream Infections: A Diagnostic Accuracy Study.
作者: M Hong Nguyen.;Cornelius J Clancy.;A William Pasculle.;Peter G Pappas.;George Alangaden.;George A Pankey.;Bryan H Schmitt.;Altaf Rasool.;Melvin P Weinstein.;Raymond Widen.;Diana R Hernandez.;Donna M Wolk.;Thomas J Walsh.;John R Perfect.;Mollie N Wilson.;Eleftherios Mylonakis.
来源: Ann Intern Med. 2019年170卷12期845-852页
Blood cultures, the gold standard for diagnosing bloodstream infections (BSIs), are insensitive and limited by prolonged time to results. The T2Bacteria Panel (T2 Biosystems) is a direct-from-blood, nonculture test that identifies the most common ESKAPE bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli).
4963. Cases in Precision Medicine: Genetic Assessment After a Sudden Cardiac Death in the Family.
作者: Ronald Laracuente.;Marc Paul Waase.;Isha Kalia.;Arthur A M Wilde.;Wendy K Chung.
来源: Ann Intern Med. 2019年170卷10期710-716页
Sudden death in a family is associated with serious anxiety among family members. Assessing the cause of death may help determine the risk for other family members, thus alleviating some anxiety. In some cases, the cause of death may be evident on autopsy; however, in cases of arrhythmias, standard autopsy will not reveal the cause of death. Evaluation of the circumstances of death, medical history of the deceased, and results of genetic testing may reveal a diagnosis. Once a diagnosis is made, relatives should receive genetic testing and clinical assessment to stratify their risk. Depending on their risk, various interventions are available, including medication, defibrillators, and lifestyle modifications.
4969. Hypertension.
Recent guidelines on diagnosis and management of high blood pressure (BP) include substantial changes and several new concepts compared with previous guidelines. These are reviewed and their clinical implications are discussed in this article. The goal is to provide a practical reference to assist clinicians with up-to-date management of patients with high BP. Important issues include new diagnostic thresholds, out-of-office BP monitoring, intensified treatment goals, and a different approach to resistant hypertension. Finally, differences among guidelines, the persistent controversies that have led to them, and their implications for clinical practice are discussed.
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