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442. Single-cell transcriptomic analysis deciphers heterogenous cancer stem-like cells in colorectal cancer and their organ-specific metastasis.
作者: Rui Li.;Xuefei Liu.;Xudong Huang.;Di Zhang.;Ziming Chen.;Jialiang Zhang.;Ruihong Bai.;Shaoping Zhang.;Hongzhe Zhao.;Zilan Xu.;Lingxing Zeng.;Lisha Zhuang.;Shujuan Wen.;Shaojia Wu.;Mei Li.;Zhixiang Zuo.;Junzhong Lin.;Dongxin Lin.;Jian Zheng.
来源: Gut. 2024年73卷3期470-484页
Metastasis is the major cause of cancer death. However, what types of heterogenous cancer cells in primary tumour and how they metastasise to the target organs remain largely undiscovered.
443. Compared to histamine-2 receptor antagonist, proton pump inhibitor induces stronger oral-to-gut microbial transmission and gut microbiome alterations: a randomised controlled trial.
作者: Jiaying Zhu.;Chuqing Sun.;Min Li.;Guoru Hu.;Xing-Ming Zhao.;Wei-Hua Chen.
来源: Gut. 2024年73卷7期1087-1097页
We aim to compare the effects of proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) on the gut microbiota through longitudinal analysis.
444. Dupilumab demonstrated efficacy and was well tolerated regardless of prior use of swallowed topical corticosteroids in adolescent and adult patients with eosinophilic oesophagitis: a subgroup analysis of the phase 3 LIBERTY EoE TREET study.
作者: Albert J Bredenoord.;Evan S Dellon.;Ikuo Hirano.;Alfredo J Lucendo.;Christoph Schlag.;Xian Sun.;Lila Glotfelty.;Leda Mannent.;Jennifer Maloney.;Elizabeth Laws.;Eric Mortensen.;Arsalan Shabbir.
来源: Gut. 2024年73卷3期398-406页
To assess the effect of long-term dupilumab on histological, symptomatic and endoscopic aspects of eosinophilic oesophagitis (EoE) in adolescent and adult patients with and without prior use of swallowed topical corticosteroids (STC) or prior inadequate response, intolerance or contraindication to STC.
446. Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barrett's oesophagus surveillance: individual-level data analysis.
作者: Emily L Black.;Emma Ococks.;Ginny Devonshire.;Alvin Wei Tian Ng.;Maria O'Donovan.;Shalini Malhotra.;Monika Tripathi.;Ahmad Miremadi.;Adam Freeman.;Hannah Coles.; .;Rebecca C Fitzgerald.
来源: Gut. 2024年73卷5期729-740页
Whether gastric metaplasia (GM) of the oesophagus should be considered as Barrett's oesophagus (BO) is controversial. Given concern intestinal metaplasia (IM) may be missed due to sampling, the UK guidelines include GM as a type of BO. Here, we investigated whether the risk of misdiagnosis and the malignant potential of GM warrant its place in the UK surveillance.
459. Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion.
作者: Yang Wang.;Qiqi Li.;Cheng Li.;Cong Wang.;Shijie Wang.;Wenjie Yuan.;Demin Yu.;Ke Zhang.;Bisheng Shi.;Xiaomei Chen.;Tiantian Liu.;Zhenghong Yuan.;Shuping Tong.;Michael Nassal.;Yu-Mei Wen.;Yong-Xiang Wang.
来源: Gut. 2024年73卷4期668-681页
Chronic hepatitis B (CHB) caused by HBV infection greatly increases the risk of liver cirrhosis and hepatocellular carcinoma. Hepatitis B surface antigen (HBsAg) plays critical roles in the pathogenesis of CHB. HBsAg loss is the key indicator for cure of CHB, but is rarely achieved by current approved anti-HBV drugs. Therefore, novel anti-HBV strategies are urgently needed to achieve sustained HBsAg loss.
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