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402. Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial.
作者: Lonne W T Meulen.;Roel M M Bogie.;Peter D Siersema.;Bjorn Winkens.;Marije S Vlug.;Frank H J Wolfhagen.;Martine Baven-Pronk.;Michael van der Voorn.;Matthijs P Schwartz.;Lauran Vogelaar.;Wouter H de Vos Tot Nederveen Cappel.;Tom C J Seerden.;Wouter L Hazen.;Ruud W M Schrauwen.;Lorenza Alvarez Herrero.;Ramon-Michel M Schreuder.;Annick B van Nunen.;Esther Stoop.;Gijs J de Bruin.;Philip Bos.;Willem A Marsman.;Edith Kuiper.;Marc de Bièvre.;Yasser A Alderlieste.;Robert Roomer.;John Groen.;Marloes Bargeman.;Monique E van Leerdam.;Linda Roberts-Bos.;Femke Boersma.;Karsten Thurnau.;Roland S de Vries.;Jos M Ramaker.;Frank P Vleggaar.;Rogier J de Ridder.;María Pellisé.;Michael J Bourke.;Ad A M Masclee.;Leon M G Moons.
来源: Gut. 2024年73卷5期741-750页
Endoscopic mucosal resection (EMR) is the preferred treatment for non-invasive large (≥20 mm) non-pedunculated colorectal polyps (LNPCPs) but is associated with an early recurrence rate of up to 30%. We evaluated whether standardised EMR training could reduce recurrence rates in Dutch community hospitals.
406. Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease.
作者: Angelo Armandi.;Tiziana Sanavia.;Ramy Younes.;Gian Paolo Caviglia.;Chiara Rosso.;Olivier Govaere.;Antonio Liguori.;Paolo Francione.;Rocìo Gallego-Duràn.;Javier Ampuero.;Grazia Pennisi.;Rocio Aller.;Dina Tiniakos.;Alastair Burt.;Ezio David.;Fabio Vecchio.;Marco Maggioni.;Daniela Cabibi.;Duncan McLeod.;Maria Jesus Pareja.;Marco Y W Zaki.;Antonio Grieco.;Per Stål.;Stergios Kechagias.;Anna Ludovica Fracanzani.;Luca Valenti.;Luca Miele.;Piero Fariselli.;Mohammed Eslam.;Salvatore Petta.;Hannes Hagström.;Jacob George.;Jörn M Schattenberg.;Manuel Romero-Gómez.;Quentin Mark Anstee.;Elisabetta Bugianesi.
来源: Gut. 2024年73卷5期825-834页
Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death.
407. Revisiting the performance of cyst fluid carcinoembryonic antigen as a diagnostic marker for pancreatic mucinous cysts: a comprehensive 20-year institutional review.
作者: Melanie C Kwan.;Martha Bishop Pitman.;Carlos Fernandez-Del Castillo.;M Lisa Zhang.
来源: Gut. 2024年73卷4期629-638页
Elevated pancreatic cyst fluid carcinoembryonic antigen (CEA) has been routinely used to classify mucinous cysts. This study incorporates original data that established the CEA ≥192 ng/mL threshold with over 20 years of additional data and reassesses the diagnostic performance of CEA for differentiating mucinous from non-mucinous cysts.
409. Treatment of non-constipated irritable bowel syndrome with the histamine 1 receptor antagonist ebastine: a randomised, double-blind, placebo-controlled trial.
作者: Lisse Decraecker.;Danny De Looze.;David P Hirsch.;Heiko De Schepper.;Joris Arts.;Philip Caenepeel.;Albert J Bredenoord.;Jeroen Kolkman.;Koen Bellens.;Kim Van Beek.;Fedrica Pia.;Willy Peetermans.;Tim Vanuytsel.;Alexandre Denadai-Souza.;Ann Belmans.;Guy Boeckxstaens.
来源: Gut. 2024年73卷3期459-469页
We evaluated the histamine 1 receptor antagonist ebastine as a potential treatment for patients with non-constipated irritable bowel syndrome (IBS) in a randomised, placebo-controlled phase 2 study.
411. High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT.
作者: Lang Bu.;Zhengkun Zhang.;Jianwen Chen.;Yizeng Fan.;Jinhe Guo.;Yaqing Su.;Huan Wang.;Xiaomei Zhang.;Xueji Wu.;Qiwei Jiang.;Bing Gao.;Lei Wang.;Kunpeng Hu.;Xiang Zhang.;Wei Xie.;Wenyi Wei.;Ming Kuang.;Jianping Guo.
来源: Gut. 2024年73卷7期1156-1168页
Whether and how the PI3K-AKT pathway, a central node of metabolic homeostasis, is responsible for high-fat-induced non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remain a mystery. Characterisation of AKT regulation in this setting will provide new strategies to combat HCC.
412. Familial coaggregation of inflammatory bowel disease with cardiovascular disease: a nationwide multigenerational cohort study.
作者: Jiangwei Sun.;Jialu Yao.;Ola Olén.;Jonas Halfvarson.;David Bergman.;Fahim Ebrahimi.;Johan Sundström.;Jonas F Ludvigsson.
来源: Gut. 2024年73卷11期e23页 415. Unveiling 8 years of duodenoscope contamination: insights from a retrospective analysis in a large tertiary care hospital.
作者: Koen van der Ploeg.;Cynthia P Haanappel.;Anne F Voor In 't Holt.;Woutrinus de Groot.;Adriana J C Bulkmans.;Nicole S Erler.;Bibi C G C Mason-Slingerland.;Juliëtte A Severin.;Margreet C Vos.;Marco J Bruno.
来源: Gut. 2024年73卷4期613-621页
Contaminated duodenoscopes caused several hospital outbreaks. Despite efforts to reduce contamination rates, 15% of patient-ready duodenoscopes are still contaminated with gastrointestinal microorganisms. This study aimed to provide an overview of duodenoscope contamination over time, identify risk factors and study the effects of implemented interventions.
416. Positive effects of diet-induced microbiome modification on GDM in mice following human faecal transfer.
作者: Sigal Frishman.;Meital Nuriel-Ohayon.;Sondra Turjeman.;Yishay Pinto.;Or Yariv.;Kinneret Tenenbaum-Gavish.;Yoav Peled.;Eran Poran.;Joseph Pardo.;Rony Chen.;Efrat Muller.;Elhanan Borenstein.;Moshe Hod.;Yoram Louzoun.;Betty Schwartz.;Eran Hadar.;Maria Carmen Collado.;Omry Koren.
来源: Gut. 2024年73卷10期e17页 417. Blood-based colorectal cancer screening in an integrated health system: a randomised trial of patient adherence.
作者: Gloria D Coronado.;Charisma L Jenkins.;Elizabeth Shuster.;Cheryl Johnson.;David Amy.;Jennifer Cook.;Samantha Sahnow.;Jamilyn M Zepp.;Rajasekhara Mummadi.
来源: Gut. 2024年73卷4期622-628页
We evaluated whether people who had not completed a faecal immunochemical test (FIT) for colorectal cancer (CRC) screening would complete a blood-based testing option if offered one during health encounters. Blood-based screening tests for CRC could add to the total number of people screened for CRC by providing another testing alternative.
418. Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis.
作者: Ming Kong.;Junjing Zhou.;Aoqi Kang.;Yameng Kuai.;Huihui Xu.;Min Li.;Xiulian Miao.;Yan Guo.;Zhiwen Fan.;Yong Xu.;Zilong Li.
来源: Gut. 2024年73卷5期810-824页
Liver fibrosis is a prelude to a host of end-stage liver diseases. Hepatic stellate cells (HSCs), switching from a quiescent state to myofibroblasts, are the major source for excessive production of extracellular matrix proteins. In the present study, we investigated the role of Suv39h1, a lysine methyltransferase, in HSC-myofibroblast transition and the implication in liver fibrosis.
419. ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo.
作者: Anja Schulz-Kuhnt.;Katharina Rühle.;Asal Javidmehr.;Michael Döbrönti.;Jana Biwank.;Selina Knittel.;Peter Neidlinger.;Jannik Leupold.;Li-Juan Liu.;Mark Dedden.;Regina Verena Taudte.;Arne Gessner.;Martin F Fromm.;Dirk Mielenz.;Lucas Kreiss.;Maximilian J Waldner.;Sebastian Schürmann.;Oliver Friedrich.;Barbara Dietel.;Rocío López-Posadas.;Christina Plattner.; .;Sebastian Zundler.;Christoph Becker.;Raja Atreya.;Markus F Neurath.;Imke Atreya.
来源: Gut. 2024年73卷4期601-612页
Mucosal T cells play a major role in inflammatory bowel disease (IBD). However, their immunometabolism during intestinal inflammation is poorly understood. Due to its impact on cellular metabolism and proinflammatory immune cell function, we here focus on the enzyme ATP citrate lyase (ACLY) in mucosal T cell immunometabolism and its relevance for IBD.
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