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381. Prognostic Implications of Evolving Universal Definitions of Periprocedural Myocardial Infarction in Patients With Acute Coronary Syndrome.
作者: Sergio Leonardi.;Antonio Landi.;Andrea Zito.;Mattia Branca.;Enrico Frigoli.;Giuseppe Ando'.;Carlo Briguori.;Paolo Calabro.;Andrea Gagnor.;Roberto Garbo.;Dik Heg.;Ugo Limbruno.;Andrea Milzi.;Elmir Omerovic.;Filippo Russo.;Manel Sabaté.;Andrea Santarelli.;Gennaro Sardella.;Paolo Tosi.;Arnoud W J Van't Hof.;Pascal Vranckx.;Marco Valgimigli.
来源: Circulation. 2026年153卷4期230-242页
The universal definition of percutaneous coronary intervention (PCI)-related myocardial infarction (MI) has been substantially updated over the years, including an increase in the biomarker threshold (from 3 to 5 times the upper reference limit) and the introduction of ancillary criteria such as ischemic symptoms and electrocardiographic or angiographic complication. The impact of these changes in patients with acute coronary syndrome (ACS) remains incompletely understood. The objective of this study was to compare prognostic implications of evolving universal definitions of PCI-MI in a large cohort of patients with ACS from the MATRIX trial (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX).
382. Inhibition of Annexin A2 Facilitates PHB2-Mediated Mitophagy in Cardiomyocytes to Alleviate Cardiac Injury and Remodeling After Infarction.
作者: Ke-Qiong Deng.;Zhendong Xu.;Qiongxin Wang.;Huan-Huan Cai.;Di Fan.;Qingqing Wu.;Xiao-Jing Zhang.;Peng Zhang.;Zhi-Gang She.;Xingguo Liu.;Xianqing Li.;Zhibing Lu.
来源: Circulation. 2026年153卷11期826-844页
Mitophagy is critically involved in cardiac injury and repair after myocardial infarction (MI), whereas the annexin A family plays an important role in mitophagy. However, the intrinsic molecular underpinnings that orchestrate the homeostasis of mitophagy in the infarcted heart remain to be fully characterized. Here, we aimed to evaluate the role of ANXA2 (annexin A2) in cardiac mitophagy in response to MI.
383. Impact of Pregnancy on Mortality in Dilated Cardiomyopathy: Immediate and 12-Month Postpartum Outcomes: Data From the InCor Pregnancy and Heart Disease Registry.
作者: Mônica Samuel Avila.;Fernando Bacal.;Fabio Fernandes.;Flavio Tarasoutchi.;Walkiria Samuel Avila.
来源: Circ Heart Fail. 2026年e013656页
Pregnant women with dilated cardiomyopathy (DCM) face high risks of complications and maternal death due to hemodynamic overload, withdrawal of teratogenic but essential therapies, and limited treatment options during pregnancy. To evaluate maternal and fetal outcomes in women with DCM during pregnancy and up to 12 months postpartum, across different etiologies, and identify predictors of maternal death.
384. Percutaneous Aorto-Coronary Bypass Graft to Prevent Coronary Obstruction Following TAVR: First Human VECTOR Procedure.
作者: Christopher G Bruce.;Vasilis C Babaliaros.;Gaetano Paone.;Patrick T Gleason.;Rim N Halaby.;Jaffar M Khan.;Toby Rogers.;Ellen Richter.;Robert J Lederman.;Adam B Greenbaum.
来源: Circ Cardiovasc Interv. 2026年19卷1期e016130页 385. GRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis.
作者: Hu Wang.;Jiaxing Wang.;Min Zhu.;Ling Jin.;Hao Cui.;Cihang Liu.;Chenyu Fan.;Hui Li.;Jichun Yang.;Ming Cui.;Jiangping Song.;Wengong Wang.;Ming Xu.
来源: Circulation. 2026年153卷10期736-753页
Imbalances in cardiac branched-chain amino acid (BCAA) metabolism and mitochondrial homeostasis are implicated in the onset and development of heart failure. However, the mechanisms triggering the downregulation of cardiac BCAA metabolism in heart failure remain unclear. Here, we identify a novel role of the RNA-binding protein GRSF1 (guanine-rich RNA sequence binding factor 1) in post-transcriptionally regulating cell-intrinsic BCAA metabolic pathways, ultimately contributing to the pathogenesis of heart failure.
386. Dual Diagnosis by Cardiac MRI of Takotsubo Syndrome and Adrenal Pheochromocytoma in Pregnancy.
作者: Soundous M'Rabet.;Thibaut Pommier.;Thibault Leclercq.;Amandine Nguyen.;Loup Guichard.;Régine Duvernay-Debin.
来源: Circ Cardiovasc Imaging. 2026年19卷2期e019133页 387. Clinical Spectrum of Children With Parvovirus B19-Associated Acute Myocarditis.
作者: Enrico Ammirati.;Giacomo Veronese.;Francesca Raimondi.;Giuseppe Alberto Annoni.;Domenico Sirico.;Francesco Bianco.;Alessio Franceschini.;Gessica Ingrasciotta.;Giovanni Meliota.;Guglielmo Capponi.;Isabella Pellicioli.;Gaia Biancamaria Chiesa.;Carlo Beretta.;Giada Colombo.;Giovanni Di Salvo.;Sandra Nonini.;Francesca Aresta.;Luca Ragni.;Tammam Hasan.;Maurizio Brighenti.;Giovanna Travi.;Olivia Leoni.;Paul Stefan Vrabie.;Michele Ercolanoni.;Giuseppe Limongelli.;Emanuele Monda.;Maria Giovanna Russo.;Alessandra Corato.;Elena Reffo.;Valentina Bucciarelli.;Sergio Filippelli.;Susanna Breviario.;Carlo Pace Napoleone.;Ugo Vairo.;Maristella Lombardi.;Nadia Assanta.;Pietro Marchese.;Paolo Ferrero.;Flavio Luciano Ribichini.;Andrea Garascia.;Michele Giovanni Mondino.;Antonio Amodeo.;Rachele Adorisio.;Ezio Bonanomi.
来源: Circulation. 2026年153卷10期699-715页
Parvovirus B19 is a DNA virus transmitted via respiratory droplets, commonly causing erythema infectiosum in children but also implicated in acute myocarditis. In 2024, an outbreak of parvovirus B19 infections was reported across Europe and the United States. Despite growing awareness, data on the clinical features and outcomes of children with parvovirus B19-associated acute myocarditis remain limited.
388. Myocardial Recovery With Mechanical Circulatory Support Is Linked to Alternative Splicing and Subcellular Localization of CAMK2D.
作者: Thomas G Martin.;Dakota R Hunt.;Christopher C Ebmeier.;Abhishek P Dhand.;Christina Alamana.;Joseph C Cleveland.;Sharon L Graw.;Sarah Bruner.;Michael R Bristow.;Luisa Mestroni.;Matthew R G Taylor.;Jason A Burdick.;Amrut V Ambardekar.;Peter M Buttrick.;Leslie A Leinwand.
来源: Circulation. 2026年153卷9期673-687页
Cardiac reverse remodeling occurs in a small subset of patients with heart failure treated with guideline-directed therapies. This phenomenon, which is defined by reduced ventricular dilatation and improved systolic function, is most common in patients receiving left ventricular assist device (LVAD) therapy. Identifying therapeutic targets for initiating reverse remodeling is an area of great clinical interest, because these patients experience improved outcomes and quality of life. Targets may be discovered among the unique molecular changes associated with LVAD-induced partial myocardial functional recovery; however, the mechanisms underlying this favorable response are incompletely understood.
389. Histone Lactylation-Mediated Metabolic Remodeling in Vascular Smooth Muscle Cells Aggravates Aortic Aneurysm and Dissection by Promoting Lactate Accumulation.
作者: Liwei Liu.;Jinyan Zhang.;Zhen Dong.;Yikai Cui.;Xiaoyi Zou.;Hao Lai.;Jiawei Gu.;Xinyu Weng.;Xuejuan Jin.;Tianyi Qiu.;Zhiqiang Pei.;Wenxuan Hong.;Ya Huang.;Wei Luo.;Lihong Pan.;Xiaolei Sun.;Beijian Zhang.;Adilan Shalamu.;Aijun Sun.;Junbo Ge.
来源: Circulation. 2026年153卷3期189-209页
Vascular smooth muscle cells (VSMCs) undergo phenotypic changes during the development of aortic aneurysm and dissection (AAD). Metabolism shifts from oxidative phosphorylation to glycolysis. Recent studies suggest that epigenetics plays a crucial role in AAD.
390. Association of Race and Ethnicity With High-Potency P2Y12 Inhibitors Prescription Among Patients With Acute MI Undergoing PCI: An Analysis From the CathPCI Registry.
作者: Hend Mansoor.;Rebecca Young.;Lisa A Kaltenbach.;Daniel M Wojdyla.;Binita Shah.;Ian C Gilchrist.;Jennifer A Rymer.;Islam Y Elgendy.
来源: Circ Cardiovasc Interv. 2026年19卷2期e015600页
Racial and ethnic disparities exist in postacute myocardial infarction (AMI) care. High-potency P2Y12 inhibitors use among patients with AMI who undergo percutaneous coronary intervention (PCI) carries a class I indication in the guidelines. This study aims to examine racial and ethnic differences in high-potency P2Y12 inhibitor prescription on discharge among patients with AMI undergoing PCI.
391. Outcomes of Patients With New Left Bundle Branch Block After TAVR: TVT Registry Insights.
作者: Nickpreet Singh.;David J Cohen.;Shmuel Chen.;Miloni A Shah.;Amanda Stebbins.;Andrzej S Kosinski.;Leo Brothers.;Sreekanth Vemulapalli.;Ajay J Kirtane.;Jose M Dizon.;Isaac George.;Martin B Leon.;Tamim M Nazif.
来源: Circ Cardiovasc Interv. 2026年19卷2期e015441页
Cardiac conduction disturbances remain the most frequent complication of transcatheter aortic valve replacement (TAVR), but the clinical implications of new left bundle branch block (LBBB) after TAVR remain controversial. Here, we aim to assess the impact of new LBBB after TAVR on patient outcomes in a large, real-world registry.
392. Invasion of Epicardial-Derived Cells to the Trabeculae Mediated by NFPs-Fgf Signaling Regulates Ventricular Compaction.
作者: Anika Nusrat.;Luqi Zhao.;Lianjie Miao.;Shiyanth Thevasagayampillai.;Xi Lu.;Aaranyah Kandasamy.;Md Areeful Haque.;Preethi H Gunaratne.;Sylvia M Evans.;Mingfu Wu.
来源: Circ Heart Fail. 2026年19卷2期e013210页
Left ventricular noncompaction cardiomyopathy (LVNC; OMIM No. 604169) is anatomically characterized by excess trabeculation and deep intertrabecular recesses. It is the third most prevalent pediatric cardiomyopathy. Despite its clinical significance, the pathogenesis of LVNC remains uncertain.
396. Dilated Cardiomyopathy-Related Mortality in the United States: Demographic and Regional Trends Over the Past 2 Decades.
作者: Ali Bin Abdul Jabbar.;Muhammad Abdullah Javed.;Selma F Mohammed.
来源: Circ Heart Fail. 2026年19卷1期e012987页
Dilated cardiomyopathy (DCM) is a common cause of heart failure and is associated with substantial morbidity and mortality. However, data on mortality trends and disparities in DCM mortality in the United States are limited. The objective of this study is to define trends and demographic and regional disparities in DCM-related mortality in the United States.
397. Prediction of Heart Failure Hospitalization or Death After TAVR.
作者: Bassim El-Sabawi.;Pratik Manandhar.;Javed Butler.;Philippe Généreux.;Marc R Dweck.;Thomas A Treibel.;David J Cohen.;Nimesh D Desai.;Vinod H Thourani.;Wayne B Batchelor.;Michael J Mack.;Martin B Leon.;JoAnn Lindenfeld.;Angela Lowenstern.;Andrzej S Kosinski.;Sreekanth Vemulapalli.;Brian R Lindman.
来源: Circ Cardiovasc Interv. 2026年19卷2期e015398页
Heart failure (HF) remains a significant burden following transcatheter aortic valve replacement, adversely impacting survival and quality of life. Identification of patients who may benefit from closer monitoring or adjunctive medical therapy to reduce the risk of HF is an unmet need. The objective of this study was to develop and internally validate a clinical prediction model to determine the 1-year risk of HF hospitalization or death after transcatheter aortic valve replacement.
398. Letter by Jelisejevas et al Regarding Article, "Prospective Observational Study on the Accuracy of Predictors of Permanent Pacemaker Secondary to High-Grade Atrioventricular Conduction Block After TAVI (CONDUCT-TAVI)".400. Artificial Intelligence-Enabled Echocardiography as a Surrogate for Multimodality Aortic Stenosis Imaging: Post Hoc Analysis of a Clinical Trial.
作者: Evangelos K Oikonomou.;Neil J Craig.;Gregory Holste.;Sumukh Vasisht Shankar.;Audrey C White.;Menaka Mahendran.;David E Newby.;Marc R Dweck.;Rohan Khera.
来源: Circ Cardiovasc Imaging. 2026年19卷2期e018353页
Accurate aortic stenosis (AS) phenotyping requires multimodality imaging which has limited availability. The digital aortic stenosis severity index (DASSi), an artificial intelligence biomarker of AS-related remodeling on single-view 2-dimensional echocardiography, predicts AS progression independent of Doppler measurements. We sought to evaluate the ability of DASSi to define personalized AS progression profiles and to validate its performance as a scalable alternative to multimodality imaging features of functional, structural, and biological AS severity.
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