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21. Contemporary TAVR for Patients With Bicuspid Aortic Valve: Importance of Specific Bicuspid Phenotypes, Raphe, Calcification, and a Lifetime Management Intention.
作者: Hector I Michelena.;Dhairya Patel.;Raj R Makkar.;Hasan Jilaihawi.
来源: Circ Cardiovasc Interv. 2025年18卷6期e015442页 22. Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk.
作者: Parag R Gajendragadkar.;Adam Von Ende.;Federico Murgia.;Alison Offer.;C Fielder Camm.;Rohan S Wijesurendra.;Barbara Casadei.;Jemma C Hopewell.
来源: Circ Genom Precis Med. 2025年18卷3期e004932页
Genome-wide association studies have clustered candidate genes associated with atrial fibrillation (AF) into biological pathways reflecting different pathophysiological mechanisms. We investigated whether these pathways associate with distinct intermediate phenotypes and confer differing risks of cardioembolic stroke.
23. Machine Learning-Based Plasma Protein Risk Score Improves Atrial Fibrillation Prediction Over Clinical and Genomic Models.
作者: Min Seo Kim.;Shaan Khurshid.;Shinwan Kany.;Lu-Chen Weng.;Sarah Urbut.;Carolina Roselli.;Leonoor Wijdeveld.;Sean J Jurgens.;Joel T Rämö.;Patrick T Ellinor.;Akl C Fahed.
来源: Circ Genom Precis Med. 2025年e004943页
Clinical factors discriminate incident atrial fibrillation (AF) risk with moderate accuracy, with only modest improvement after incorporation of polygenic risk scores. Whether emerging large-scale proteomic profiling can augment AF risk estimation is unknown.
24. Cost-Effectiveness of Gamification, Financial Incentives, or Both to Increase Physical Activity Among Patients With Elevated Risk for Cardiovascular Disease.
作者: Louise B Russell.;Kevin G M Volpp.;Mitesh S Patel.;Neel P Chokshi.;Samantha Coratti.;David Farraday.;Laurie Norton.;Charles Rareshide.;Jingsan Zhu.;Tamar Klaiman.;Julia E Szymczak.;Dylan S Small.;Alexander C Fanaroff.
来源: Circ Cardiovasc Qual Outcomes. 2025年e011839页
The BE ACTIVE trial (Behavioral Economic Approaches to Increase Physical Activity Among Patients with Elevated Risk for Cardiovascular Disease) documented the effectiveness, compared with an attention control arm that received daily text messages, of gamification, financial incentives, or gamification+financial incentives to increase steps/day. Increases in daily step count are associated with longer life expectancy, but understanding the cost-effectiveness of these interventions is essential for payers and other stakeholders seeking to implement findings.
27. Family Screening in Relatives at Risk for Plakophilin-2-Associated Arrhythmogenic Right Ventricular Cardiomyopathy.
作者: Steven A Muller.;Babken Asatryan.;Alessio Gasperetti.;Maarten J Cramer.;Ahmad S Amin.;Peter Loh.;Richard T Carrick.;Moniek G P J Cox.;Pim van der Harst.;Marish I F J Oerlemans.;Crystal Tichnell.;Sing-Chien Yap.;Brittney Murray.;Stefan L Zimmerman.;J Peter van Tintelen.;Hugh Calkins.;Anneline S J M Te Riele.;Cynthia A James.
来源: Circulation. 2025年
Penetrance and risk of ventricular arrhythmias (VAs) in arrhythmogenic right ventricular cardiomyopathy (ARVC) are increasingly recognized as being genotype specific. Therefore, genotype-informed family screening protocols may lead to safer and more personalized recommendations than the current one-size-fits-all screening recommendations. We aimed to develop a safe, evidence-based plakophilin-2 (PKP2)-specific longitudinal screening algorithm.
30. Response by Vukadinović et al to Letter Regarding Article, "Effects of Catheter-Based Renal Denervation in Hypertension: A Systematic Review and Meta-Analysis".32. Influence of Resuscitated Cardiac Arrest on Efficacy and Safety of Extracorporeal Life Support in Infarct-Related Cardiogenic Shock: A Substudy of the ECLS-SHOCK Trial.
作者: Uwe Zeymer.;Anne Freund.;Marko Noc.;Ibrahim Akin.;Kurt Huber.;Janine Pöss.;Steffen Schneider.;Tienush Rassaf.;Christian Jung.;Eike Tigges.;Taoufik Ouarrak.;Steffen Desch.;Holger Thiele.
来源: Circulation. 2025年151卷24期1752-1754页 33. Impact of the Volume-Based Procurement Policy on the Use of Coronary Stents in China: Cross-Sectional Study.
作者: Zhao Yang.;Wei Zhao.;Liangyu Ni.;Linlin Da.;Yongyi Wu.;Yuxi Li.;Qiyun Zhu.;Jianping Li.;Bin Jiang.
来源: Circ Cardiovasc Qual Outcomes. 2025年e011374页 34. Response by Doust et al to Letter Regarding Article "Assessing the Accuracy of Cardiovascular Disease Prediction Using Female-Specific Risk Factors in Women Aged 45 to 69 in the UK Biobank Study".
作者: Jenny Doust.;Mohammad Reza Baneshi.;Hsin-Fang Chung.;Louise Forsyth Wilson.;Gita Devi Mishra.
来源: Circ Cardiovasc Qual Outcomes. 2025年e012021页 35. Letter by Rich-Edwards et al Regarding Article, "Assessing the Accuracy of Cardiovascular Disease Prediction Using Female-Specific Risk Factors in Women Aged 45 to 69 Years in the UK Biobank Study".
作者: Janet W Rich-Edwards.;Kathryn M Rexrode.;Tiange Liu.;Chuan Hong.;Johanna Quist-Nelson.;Marie-Louise Meng.;Hanne Dahl Vonen.;Michael Pencina.;Ricardo Henao.
来源: Circ Cardiovasc Qual Outcomes. 2025年e011970页 37. Identifying a Heterogeneous Effect of Atrial Fibrillation Screening in Older Adults: A Secondary Analysis of the VITAL-AF Trial.
作者: Sachin J Shah.;Jay M Iyer.;Leila Agha.;Yuchiao Chang.;Jeffrey M Ashburner.;Steven J Atlas.;David D McManus.;Patrick T Ellinor.;Steven A Lubitz.;Daniel E Singer.
来源: Circ Cardiovasc Qual Outcomes. 2025年e011482页
One-time atrial fibrillation (AF) screening trials in older adults have produced mixed results. In a secondary analysis of the VITAL-AF trial, we aimed to identify a subset of people in whom such screening is effective, using effect-based and risk-based approaches.
38. Association Between Automated Coronary Artery Calcium From Routine Chest Computed Tomography Scans and Cardiovascular Risk in Patients With Colorectal or Gastric Cancer.
作者: Subin Kim.;Seonji Kim.;Min Jae Cha.;Hyo Song Kim.;Han Sang Kim.;Woo Jin Hyung.;Iksung Cho.;Seng Chan You.
来源: Circ Cardiovasc Qual Outcomes. 2025年e011656页
As cardiovascular disease (CVD) is the leading cause of noncancer mortality in colorectal or gastric cancer patients, it is essential to identify patients at increased CVD risk. Coronary artery calcium (CAC) is an established predictor of atherosclerotic CVD; however, its application is limited in this population. This study evaluates the association between automated CAC scoring using chest computed tomography and atherosclerotic CVD risk in colorectal or gastric cancer patients.
39. Inactivation of RhoA for Hypertension Treatment Through the TRPV4-RhoA-RhoGDI1 Axis.
作者: Jiawen Wang.;Zhen Yuan.;Na Yu.;Qian Jiao.;Honglei Zhou.;Wenjie Liao.;Jiwei Shan.;Shanshan Ruan.;Yi Zhao.;Ya Mo.;Luyao Qi.;Tiejun Li.;Jianjun Fu.;Bowen Ke.;Yufang Xu.;Xuhong Qian.;Jian Zhang.;Zhenjiang Zhao.;Shiliang Li.;Rui Wang.;Honglin Li.
来源: Circulation. 2025年
The RhoA (Ras homolog family member A) signaling pathway is pivotal in regulating vascular smooth muscle cells (VSMCs) function and blood pressure homeostasis. Current inhibitors of the RhoA signaling pathway are limited in hypertension treatment, suffering from poor efficacy, insufficient specificity, and developmental challenges.
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