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344. Cholecystectomy following EUS-guided gallbladder drainage in patients with acute cholecystitis at high surgical risk: friend or foe?
作者: Alberto Larghi.;Roy L J van Wanrooij.;Michiel Bronswijk.;Giuseppe Vanella.;Rastislav Kunda.;Manuel Pérez-Miranda.;Jeanin E Van-Hooft.;Marc A Barthet.;Paolo Giorgio Arcidiacono.;Schalk Willem Van der Merwe.
来源: Gut. 2024年73卷12期e40页 346. Smoking-related Lactobacillus and immune cell infiltration in colorectal cancer: evidence from a population-based study.
作者: Silu Chen.;Junyi Xin.;Dongying Gu.;Huiqin Li.;Rui Zheng.;Shuwei Li.;Zhengdong Zhang.;Mulong Du.;Meilin Wang.
来源: Gut. 2024年74卷1期e3页 347. New entity of adult ultra-short coeliac disease: the first international cohort and case-control study.
作者: Suneil A Raju.;Emily A Greenaway.;Annalisa Schiepatti.;Giovanni Arpa.;Nicoletta Vecchione.;Chao LA Jian.;Charlotte Grobler.;Margherita Maregatti.;Olivia Green.;Freya J Bowker-Howell.;Mohamed G Shiha.;Hugo A Penny.;Simon S Cross.;Carolina Ciacci.;Kamran Rostami.;Shokoufeh Ahmadipour.;Afshin Moradi.;Mohammad Rostami-Nejad.;Federico Biagi.;Umberto Volta.;Michelangelo Fiorentino.;Benjamin Lebwohl.;Peter Hr Green.;Suzanne Lewis.;Javier Molina-Infante.;Pilar Mata-Romero.;Valentina Vaira.;Luca Elli.;Irfan Soykan.;Arzu Ensari.;David S Sanders.
来源: Gut. 2024年73卷7期1124-1130页
Ultra-short coeliac disease (USCD) is defined as villous atrophy only present in the duodenal bulb (D1) with concurrent positive coeliac serology. We present the first, multicentre, international study of patients with USCD.
352. Function of mast cell and bile-cholangiocarcinoma interplay in cholangiocarcinoma microenvironment.
作者: Anda Shi.;Zengli Liu.;Zhongqi Fan.;Kangshuai Li.;Xingkai Liu.;Yongchang Tang.;Jiaming Hu.;Xingyong Li.;Lizhuang Shu.;Liming Zhao.;Lingling Huang.;Zhiyue Zhang.;Guoyue Lv.;Zongli Zhang.;Yunfei Xu.
来源: Gut. 2024年73卷8期1350-1363页
The correlation between cholangiocarcinoma (CCA) progression and bile is rarely studied. Here, we aimed to identify differential metabolites in benign and malignant bile ducts and elucidate the generation, function and degradation of bile metabolites.
353. PNPLA3 fatty liver allele was fixed in Neanderthals and segregates neutrally in humans.
作者: Andreas Geier.;Jonas Trost.;Ke Wang.;Clemens Schmid.;Marcin Krawczyk.;Stephan Schiffels.
来源: Gut. 2024年73卷6期1008-1014页
Fat deposition is modulated by environmental factors and genetic predisposition. Genome-wide association studies identified PNPLA3 p.I148M (rs738409) as a common variant that increases risk of developing liver steatosis. When and how this variant evolved in humans has not been studied to date.
356. Genetic and transcriptomic landscape of colonic diverticulosis.
作者: Jungkyun Seo.;Hongwei Liu.;Kristin Young.;Xinruo Zhang.;Temitope O Keku.;Corbin D Jones.;Kari E North.;Robert S Sandler.;Anne F Peery.
来源: Gut. 2024年73卷6期932-940页
Colonic diverticulosis is a prevalent condition among older adults, marked by the presence of thin-walled pockets in the colon wall that can become inflamed, infected, haemorrhage or rupture. We present a case-control genetic and transcriptomic study aimed at identifying the genetic and cellular determinants underlying this condition and the relationship with other gastrointestinal disorders.
357. Absence of a pancreatic microbiome in intraductal papillary mucinous neoplasm.
作者: Marie-Madlen Pust.;Darío Missael Rocha Castellanos.;Kara Rzasa.;Andrea Dame.;Gleb Pishchany.;Charnwit Assawasirisin.;Andrew Liss.;Carlos Fernandez-Del Castillo.;Ramnik J Xavier.
来源: Gut. 2024年73卷7期1131-1141页
This study aims to validate the existence of a microbiome within intraductal papillary mucinous neoplasm (IPMN) that can be differentiated from the taxonomically diverse DNA background of next-generation sequencing procedures.
360. MASH Resolution Index: development and validation of a non-invasive score to detect histological resolution of MASH.
作者: Rohit Loomba.;Maral Amangurbanova.;Ricki Bettencourt.;Egbert Madamba.;Harris Siddiqi.;Lisa Richards.;Cynthia Behling.;Claude B Sirlin.;Mildred D Gottwald.;Shibao Feng.;Maya Margalit.;Daniel Q Huang.
来源: Gut. 2024年73卷8期1343-1349页
Dynamic changes in non-invasive tests, such as changes in alanine aminotransferase (ALT) and MRI proton-density-fat-fraction (MRI-PDFF), may help to detect metabolic dysfunction-associated steatohepatitis (MASH) resolution, but a combination of non-invasive tests may be more accurate than either alone. We developed a novel non-invasive score, the MASH Resolution Index, to detect the histological resolution of MASH.
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