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3461. Population-based assessment of the outcomes in patients with postcolonoscopy colorectal cancers.
作者: Anand Govindarajan.;Linda Rabeneck.;Lingsong Yun.;Jill Tinmouth.;Lawrence F Paszat.;Nancy N Baxter.
来源: Gut. 2016年65卷6期971-6页
The potential for cancers to not be detected on colonoscopy is increasingly recognised, but little is known about patient outcomes. The objective of this study was to assess the outcomes of patients diagnosed with postcolonoscopy colorectal cancers (PCCRCs).
3462. Multimodality endoscopic eradication for neoplastic Barrett oesophagus: results of an European multicentre study (EURO-II).
作者: K Nadine Phoa.;Roos E Pouw.;Raf Bisschops.;Oliver Pech.;Krish Ragunath.;Bas L A M Weusten.;Brigitte Schumacher.;Bjorn Rembacken.;Alexander Meining.;Helmut Messmann.;Erik J Schoon.;Liebwin Gossner.;Jayan Mannath.;C A Seldenrijk.;Mike Visser.;Toni Lerut.;Stefan Seewald.;Fiebo J ten Kate.;Christian Ell.;Horst Neuhaus.;Jacques J G H M Bergman.
来源: Gut. 2016年65卷4期555-62页
Focal endoscopic resection (ER) followed by radiofrequency ablation (RFA) safely and effectively eradicates Barrett's oesophagus (BO) containing high-grade dysplasia (HGD) and/or early cancer (EC) in smaller studies with limited follow-up. Herein, we report long-term outcomes of combined ER and RFA for BO (HGD and/or EC) from a single-arm multicentre interventional study.
3463. Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants.
作者: Sung Noh Hong.;Changho Park.;Soo Jung Park.;Chang Kyun Lee.;Byong Duk Ye.;You Sun Kim.;Seungbok Lee.;Jeesoo Chae.;Jong-Il Kim.;Young-Ho Kim.; .
来源: Gut. 2016年65卷5期788-96页
Genome wide association studies (GWAS) and meta-analyses for Crohn's disease (CD) have not fully explained the heritability of CD, suggesting that additional loci are yet to be found and that the known loci may contain high effect rare risk variants that have thus far gone undetected by GWAS. While the cost of deep sequencing remains too high to analyse many samples, targeted sequencing of pooled DNA samples allows the efficient and cost effective capture of all variations in a target region.
3464. Clinical and endoscopic predictors of cytological dysplasia or cancer in a prospective multicentre study of large sessile serrated adenomas/polyps.
作者: Nicholas G Burgess.;Maria Pellise.;Kavinderjit S Nanda.;Luke F Hourigan.;Simon A Zanati.;Gregor J Brown.;Rajvinder Singh.;Stephen J Williams.;Spiro C Raftopoulos.;Donald Ormonde.;Alan Moss.;Karen Byth.;Heok P'Ng.;Duncan McLeod.;Michael J Bourke.
来源: Gut. 2016年65卷3期437-46页
The serrated neoplasia pathway accounts for up to 30% of all sporadic colorectal cancers (CRCs). Sessile serrated adenomas/polyps (SSA/Ps) with cytological dysplasia (SSA/P-D) are a high-risk serrated CRC precursor with little existing data. We aimed to describe the clinical and endoscopic predictors of SSA/P-D and high grade dysplasia (HGD) or cancer.
3465. Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease.
作者: James B Canavan.;Cristiano Scottà.;Anna Vossenkämper.;Rimma Goldberg.;Matthew J Elder.;Irit Shoval.;Ellen Marks.;Emilie Stolarczyk.;Jonathan W Lo.;Nick Powell.;Henrieta Fazekasova.;Peter M Irving.;Jeremy D Sanderson.;Jane K Howard.;Simcha Yagel.;Behdad Afzali.;Thomas T MacDonald.;Maria P Hernandez-Fuentes.;Nahum Y Shpigel.;Giovanna Lombardi.;Graham M Lord.
来源: Gut. 2016年65卷4期584-94页
Thymus-derived regulatory T cells (Tregs) mediate dominant peripheral tolerance and treat experimental colitis. Tregs can be expanded from patient blood and were safely used in recent phase 1 studies in graft versus host disease and type 1 diabetes. Treg cell therapy is also conceptually attractive for Crohn's disease (CD). However, barriers exist to this approach. The stability of Tregs expanded from Crohn's blood is unknown. The potential for adoptively transferred Tregs to express interleukin-17 and exacerbate Crohn's lesions is of concern. Mucosal T cells are resistant to Treg-mediated suppression in active CD. The capacity for expanded Tregs to home to gut and lymphoid tissue is unknown.
3466. Efficacy and safety of endoscopic resection of large colorectal polyps: a systematic review and meta-analysis.
作者: C Hassan.;A Repici.;P Sharma.;L Correale.;A Zullo.;M Bretthauer.;C Senore.;C Spada.;Cristina Bellisario.;P Bhandari.;D K Rex.
来源: Gut. 2016年65卷5期806-20页
To assess the efficacy and safety of endoscopic resection of large colorectal polyps.
3467. Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1.
作者: QiQi Zhou.;Liuqing Yang.;Scott Larson.;Sapreet Basra.;Shehzad Merwat.;Alai Tan.;Carlo Croce.;G Nicholas Verne.
来源: Gut. 2016年65卷5期797-805页
Many patients with irritable bowel syndrome IBS not only have abdominal pain but also may suffer from visceral hypersensitivity and heighted visceral nociception. Moreover, IBS has few effective therapeutic agents and mechanisms of disease are unclear. Our goals were to (i) identify microRNA (miRNA) expression, signalling and targets in human colon (controls; patients with IBS); (ii) verify in vitro, IBS-associated changes in miRNAs, especially miR-199, which is complementary to the transient receptor potential vanilloid type 1 (TRPV1) gene; and (iii) determine whether modulating the expression of miRNAs in vivo, especially miR-199, reverses associated changes and pathological hallmarks of visceral hypersensitivity via TRPV1 signalling.
3468. Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.
作者: Toshihiro Matsukawa.;Kumi Izawa.;Masamichi Isobe.;Mariko Takahashi.;Akie Maehara.;Yoshinori Yamanishi.;Ayako Kaitani.;Ko Okumura.;Takanori Teshima.;Toshio Kitamura.;Jiro Kitaura.
来源: Gut. 2016年65卷5期777-87页
Extracellular ATP mediates mast cell-dependent intestinal inflammation via P2X7 purinoceptors. We have previously shown that CD300f (also called the leucocyte mono-immunoglobulin-like receptor 3 (LMIR3)) suppresses immunoglobulin E-dependent and mast cell-dependent allergic responses by binding to ceramide. The aim of the present study was to clarify the role of ceramide-LMIR3 interaction in the development of IBD.
3469. The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study.
作者: Andres J Yarur.;Anjali Jain.;Daniel A Sussman.;Jamie S Barkin.;Maria A Quintero.;Fred Princen.;Richard Kirkland.;Amar R Deshpande.;Sharat Singh.;Maria T Abreu.
来源: Gut. 2016年65卷2期249-55页
The aim of this study was to assess the correlation between serum and intestinal anti-tumour necrosis factor (TNF) levels, and their relationship to endoscopic disease activity and levels of TNF.
3470. Association between ultrasonography screening and mortality in patients with hepatocellular carcinoma: a nationwide cohort study.
作者: Chun-Ying Wu.;Yao-Chun Hsu.;Hsiu J Ho.;Yi-Ju Chen.;Teng-Yu Lee.;Jaw-Town Lin.
来源: Gut. 2016年65卷4期693-701页
Current guidelines recommend screening for hepatocellular carcinoma (HCC) in high-risk populations. However, the effectiveness of screening in reducing mortality has been challenged. In addition, it is unclear which subgroups benefit most from HCC screening.
3471. Leadership training to improve adenoma detection rate in screening colonoscopy: a randomised trial.
作者: Michal F Kaminski.;John Anderson.;Roland Valori.;Ewa Kraszewska.;Maciej Rupinski.;Jacek Pachlewski.;Ewa Wronska.;Michael Bretthauer.;Siwan Thomas-Gibson.;Ernst J Kuipers.;Jaroslaw Regula.
来源: Gut. 2016年65卷4期616-24页
Suboptimal adenoma detection rate (ADR) at colonoscopy is associated with increased risk of interval colorectal cancer. It is uncertain how ADR might be improved. We compared the effect of leadership training versus feedback only on colonoscopy quality in a countrywide randomised trial.
3472. Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells.
作者: Azadeh Arabzadeh.;Jeremy Dupaul-Chicoine.;Valérie Breton.;Sina Haftchenary.;Sara Yumeen.;Claire Turbide.;Maya Saleh.;Kevin McGregor.;Celia M T Greenwood.;Uri David Akavia.;Richard S Blumberg.;Patrick T Gunning.;Nicole Beauchemin.
来源: Gut. 2016年65卷5期821-9页
Nearly 20%-29% of patients with colorectal cancer (CRC) succumb to liver or lung metastasis and there is a dire need for novel targets to improve the survival of patients with metastasis. The long isoform of the Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1-L or CC1-L) is a key regulator of immune surveillance in primary CRC, but its role in metastasis remains largely unexplored. We have examined how CC1-L expression impacts on colon cancer liver metastasis.
3473. Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. Results from a prospective study.
作者: Erica Villa.;Rosina Critelli.;Barbara Lei.;Guido Marzocchi.;Calogero Cammà.;Gianluigi Giannelli.;Patrizia Pontisso.;Giuseppe Cabibbo.;Marco Enea.;Stefano Colopi.;Cristian Caporali.;Teresa Pollicino.;Fabiola Milosa.;Aimilia Karampatou.;Paola Todesca.;Elena Bertolini.;Livia Maccio.;Maria Luz Martinez-Chantar.;Elena Turola.;Mariagrazia Del Buono.;Nicola De Maria.;Stefano Ballestri.;Filippo Schepis.;Paola Loria.;Giorgio Enrico Gerunda.;Luisa Losi.;Umberto Cillo.
来源: Gut. 2016年65卷5期861-9页
The biological heterogeneity of hepatocellular carcinoma (HCC) makes prognosis difficult. We translate the results of a genome-wide high-throughput analysis into a tool that accurately predicts at presentation tumour growth and survival of patients with HCC.
3474. Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum.
作者: Elizabeth R Mann.;David Bernardo.;Nicholas R English.;Jon Landy.;Hafid O Al-Hassi.;Simon T C Peake.;Ripple Man.;Timothy R Elliott.;Henning Spranger.;Gui Han Lee.;Alyssa Parian.;Steven R Brant.;Mark Lazarev.;Ailsa L Hart.;Xuhang Li.;Stella C Knight.
来源: Gut. 2016年65卷2期256-70页
Dendritic cells (DC) mediate intestinal immune tolerance. Despite striking differences between the colon and the ileum both in function and bacterial load, few studies distinguish between properties of immune cells in these compartments. Furthermore, information of gut DC in humans is scarce. We aimed to characterise human colonic versus ileal DC.
3475. Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein.
作者: Giuseppe A Sautto.;Karin Wisskirchen.;Nicola Clementi.;Matteo Castelli.;Roberta A Diotti.;Julia Graf.;Massimo Clementi.;Roberto Burioni.;Ulrike Protzer.;Nicasio Mancini.
来源: Gut. 2016年65卷3期512-23页
The recent availability of novel antiviral drugs has raised new hope for a more effective treatment of hepatitis C virus (HCV) infection and its severe sequelae. However, in the case of non-responding or relapsing patients, alternative strategies are needed. To this end we have used chimeric antigen receptors (CARs), a very promising approach recently used in several clinical trials to redirect primary human T cells against different tumours. In particular, we designed the first CARs against HCV targeting the HCV/E2 glycoprotein (HCV/E2).
3476. Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery.
作者: Thomas Reinert.;Lone V Schøler.;Rune Thomsen.;Heidi Tobiasen.;Søren Vang.;Iver Nordentoft.;Philippe Lamy.;Anne-Sofie Kannerup.;Frank V Mortensen.;Katrine Stribolt.;Stephen Hamilton-Dutoit.;Hans J Nielsen.;Søren Laurberg.;Niels Pallisgaard.;Jakob S Pedersen.;Torben F Ørntoft.;Claus L Andersen.
来源: Gut. 2016年65卷4期625-34页
To develop an affordable and robust pipeline for selection of patient-specific somatic structural variants (SSVs) being informative about radicality of the primary resection, response to adjuvant therapy, incipient recurrence and response to treatment performed in relation to diagnosis of recurrence.
3477. Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis.
作者: Oriol Morales-Ibanez.;Silvia Affò.;Daniel Rodrigo-Torres.;Delia Blaya.;Cristina Millán.;Mar Coll.;Luis Perea.;Gemma Odena.;Thomas Knorpp.;Markus F Templin.;Montserrat Moreno.;José Altamirano.;Rosa Miquel.;Vicente Arroyo.;Pere Ginès.;Juan Caballería.;Pau Sancho-Bru.;Ramon Bataller.
来源: Gut. 2016年65卷5期840-51页
Alcoholic hepatitis (AH) is often associated with advanced fibrosis, which negatively impacts survival. We aimed at identifying kinases deregulated in livers from patients with AH and advanced fibrosis in order to discover novel molecular targets.
3478. The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon.
作者: Wesley A Grimm.;Jeannette S Messer.;Stephen F Murphy.;Thomas Nero.;James P Lodolce.;Christopher R Weber.;Mark F Logsdon.;Sarah Bartulis.;Brooke E Sylvester.;Amanda Springer.;Urszula Dougherty.;Timothy B Niewold.;Sonia S Kupfer.;Nathan Ellis.;Dezheng Huo.;Marc Bissonnette.;David L Boone.
来源: Gut. 2016年65卷3期456-64页
ATG16L1 is an autophagy gene known to control host immune responses to viruses and bacteria. Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously identified as a risk factor in Crohn's disease (CD), was associated with more favourable clinical outcomes in thyroid cancer. Mechanisms underlying this observation have not been proposed, nor is it clear whether an association between Thr300Ala and clinical outcomes will be observed in other cancers. We hypothesised that Thr300Ala influences clinical outcome in human colorectal cancer (CRC) and controls innate antiviral pathways in colon cancer cells.
3479. Training and competence assessment in GI endoscopy: a systematic review.
作者: Vivian E Ekkelenkamp.;Arjun D Koch.;Robert A de Man.;Ernst J Kuipers.
来源: Gut. 2016年65卷4期607-15页
Training procedural skills in GI endoscopy once focused on threshold numbers. As threshold numbers poorly reflect individual competence, the focus gradually shifts towards a more individual approach. Tools to assess and document individual learning progress are being developed and incorporated in dedicated training curricula. However, there is a lack of consensus and training guidelines differ worldwide, which reflects uncertainties on optimal set-up of a training programme.
3480. Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress.
作者: Hassan Melhem.;Franck Hansmannel.;Aude Bressenot.;Syue-Fang Battaglia-Hsu.;Vincent Billioud.;Jean Marc Alberto.;Jean Louis Gueant.;Laurent Peyrin-Biroulet.
来源: Gut. 2016年65卷4期595-606页
Methyl donor deficiency (MDD) aggravates experimental colitis in rats and increases endoplasmic reticulum (ER) stress through decreased sirtuin 1 (SIRT1) in neuronal cells and myocardium. ER stress plays a key role in IBD pathogenesis.
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