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3461. Exome sequencing identifies MUTYH mutations in a family with colorectal cancer and an atypical phenotype.
作者: Nuria Seguí.;Matilde Navarro.;Marta Pineda.;Nicole Köger.;Fernando Bellido.;Sara González.;Olga Campos.;Silvia Iglesias.;Rafael Valdés-Mas.;Adriana López-Doriga.;Marta Gut.;Ignacio Blanco.;Conxi Lázaro.;Gabriel Capellá.;Xose S Puente.;Guido Plotz.;Laura Valle.
来源: Gut. 2015年64卷2期355-6页 3462. TBL1XR1 promotes lymphangiogenesis and lymphatic metastasis in esophageal squamous cell carcinoma.
作者: Liping Liu.;Chuyong Lin.;Weijiang Liang.;Shu Wu.;Aibin Liu.;Jueheng Wu.;Xin Zhang.;Pengli Ren.;Mengfeng Li.;Libing Song.
来源: Gut. 2015年64卷1期26-36页
Transducin (β)-like 1 X-linked receptor 1 (TBL1XR1) plays an important role in controlling the precisely regulated switch between gene repression and gene activation in transcriptional regulation. We investigated its biological function and clinical significance in esophageal squamous cell carcinoma (ESCC).
3463. An updated Asia Pacific Consensus Recommendations on colorectal cancer screening.
作者: J J Y Sung.;S C Ng.;F K L Chan.;H M Chiu.;H S Kim.;T Matsuda.;S S M Ng.;J Y W Lau.;S Zheng.;S Adler.;N Reddy.;K G Yeoh.;K K F Tsoi.;J Y L Ching.;E J Kuipers.;L Rabeneck.;G P Young.;R J Steele.;D Lieberman.;K L Goh.; .
来源: Gut. 2015年64卷1期121-32页
Since the publication of the first Asia Pacific Consensus on Colorectal Cancer (CRC) in 2008, there are substantial advancements in the science and experience of implementing CRC screening. The Asia Pacific Working Group aimed to provide an updated set of consensus recommendations.
3464. A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS.
作者: Dan Rosmarin.;Claire Palles.;Alistair Pagnamenta.;Kulvinder Kaur.;Guillermo Pita.;Miguel Martin.;Enric Domingo.;Angela Jones.;Kimberley Howarth.;Luke Freeman-Mills.;Elaine Johnstone.;Haitao Wang.;Sharon Love.;Claire Scudder.;Patrick Julier.;Ceres Fernández-Rozadilla.;Clara Ruiz-Ponte.;Angel Carracedo.;Sergi Castellvi-Bel.;Antoni Castells.;Anna Gonzalez-Neira.;Jenny Taylor.;Rachel Kerr.;David Kerr.;Ian Tomlinson.
来源: Gut. 2015年64卷1期111-20页
Capecitabine is an oral 5-fluorouracil (5-FU) pro-drug commonly used to treat colorectal carcinoma and other tumours. About 35% of patients experience dose-limiting toxicity. The few proven genetic biomarkers of 5-FU toxicity are rare variants and polymorphisms, respectively, at candidate loci dihydropyrimidine dehydrogenase (DPYD) and thymidylate synthase (TYMS).
3465. Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives.
作者: Aung Ko Win.;Daniel D Buchanan.;Christophe Rosty.;Robert J MacInnis.;James G Dowty.;Gillian S Dite.;Graham G Giles.;Melissa C Southey.;Joanne P Young.;Mark Clendenning.;Michael D Walsh.;Rhiannon J Walters.;Alex Boussioutas.;Thomas C Smyrk.;Stephen N Thibodeau.;John A Baron.;John D Potter.;Polly A Newcomb.;Loïc Le Marchand.;Robert W Haile.;Steven Gallinger.;Noralane M Lindor.;John L Hopper.;Dennis J Ahnen.;Mark A Jenkins.
来源: Gut. 2015年64卷1期101-10页
To estimate risk of colorectal cancer (CRC) for first-degree relatives of CRC cases based on CRC molecular subtypes and tumour pathology features.
3466. Functional analysis of ABCB4 mutations relates clinical outcomes of progressive familial intrahepatic cholestasis type 3 to the degree of MDR3 floppase activity.
作者: Raquel Gordo-Gilart.;Sara Andueza.;Loreto Hierro.;Pilar Martínez-Fernández.;Daniel D'Agostino.;Paloma Jara.;Luis Alvarez.
来源: Gut. 2015年64卷1期147-55页
Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a potentially lethal autosomal recessive liver disease associated with mutations in ABCB4, the gene encoding the canalicular translocator of phosphatidylcholine MDR3. While some affected children benefit from ursodeoxycholic acid (UDCA) therapy, others evolve to end-stage liver disease. We aimed to evaluate whether these different outcomes are related to the impact of ABCB4 mutations.
3467. The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation.
作者: Mariagnese Barbera.;Massimiliano di Pietro.;Elaine Walker.;Charlotte Brierley.;Shona MacRae.;Benjamin D Simons.;Phil H Jones.;John Stingl.;Rebecca C Fitzgerald.
来源: Gut. 2015年64卷1期11-9页
Knowledge of the cellular mechanisms involved in homeostasis of human squamous oesophagus in the steady state and following chronic injury is limited. We aimed to better understand these mechanisms by using a functional 3D approach.
3468. XIAP variants in male Crohn's disease.
作者: Yvonne Zeissig.;Britt-Sabina Petersen.;Snezana Milutinovic.;Esther Bosse.;Gabriele Mayr.;Kenneth Peuker.;Jelka Hartwig.;Andreas Keller.;Martina Kohl.;Martin W Laass.;Susanne Billmann-Born.;Heide Brandau.;Alfred C Feller.;Christoph Röcken.;Martin Schrappe.;Philip Rosenstiel.;John C Reed.;Stefan Schreiber.;Andre Franke.;Sebastian Zeissig.
来源: Gut. 2015年64卷1期66-76页
The genetic basis of inflammatory bowel disease (IBD) is incompletely understood. The aim of this study was to identify rare genetic variants involved in the pathogenesis of IBD.
3469. Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4.
作者: Liang Li.;Jing Tang.;Baohua Zhang.;Wen Yang.;Miyang LiuGao.;Ruoyu Wang.;Yexiong Tan.;Jianling Fan.;Yanxin Chang.;Jing Fu.;Feng Jiang.;Caiyang Chen.;Yingcheng Yang.;Jin Gu.;Dingming Wu.;Linna Guo.;Dan Cao.;Hengyu Li.;Guangwen Cao.;Mengchao Wu.;Michael Q Zhang.;Lei Chen.;Hongyang Wang.
来源: Gut. 2015年64卷1期156-67页
Liver tumour-initiating cells (T-ICs) are critical for hepatocarcinogenesis. However, the underlying mechanism regulating the function of liver T-ICs remains unclear.
3471. Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial--ANRS HB02 VAC-ADN.
作者: H Fontaine.;S Kahi.;C Chazallon.;M Bourgine.;A Varaut.;C Buffet.;O Godon.;J F Meritet.;Y Saïdi.;M L Michel.;D Scott-Algara.;J P Aboulker.;S Pol.; .
来源: Gut. 2015年64卷1期139-47页
The antiviral efficacy of nucleos(t)ide analogues whose main limitation is relapse after discontinuation requires long-term therapy. To overcome the risk of relapse and virological breakthrough during long-term therapy, we performed a phase I/II, open, prospective, multicentre trial using a HBV envelope-expressing DNA vaccine.
3479. Paneth cell marker CD24 in NOD2 knockout organoids and in inflammatory bowel disease (IBD).
作者: Johan Van Limbergen.;Kaoru Geddes.;Paul Henderson.;Richard K Russell.;Hazel E Drummond.;Jack Satsangi.;Anne M Griffiths.;Dana J Philpott.;David C Wilson.
来源: Gut. 2015年64卷2期353-4页 |