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3421. A multicentre comparative prospective blinded analysis of EUS and MRI for screening of pancreatic cancer in high-risk individuals.
作者: F Harinck.;I C A W Konings.;I Kluijt.;J W Poley.;J E van Hooft.;H M van Dullemen.;C Y Nio.;N C Krak.;J J Hermans.;C M Aalfs.;A Wagner.;R H Sijmons.;K Biermann.;C H van Eijck.;D J Gouma.;M G W Dijkgraaf.;P Fockens.;M J Bruno.; .
来源: Gut. 2016年65卷9期1505-13页
Endoscopic ultrasonography (EUS) and MRI are promising tests to detect precursors and early-stage pancreatic ductal adenocarcinoma (PDAC) in high-risk individuals (HRIs). It is unclear which screening technique is to be preferred. We aimed to compare the efficacy of EUS and MRI in their ability to detect clinically relevant lesions in HRI.
3422. A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication.
作者: Kai-feng Pan.;Lian Zhang.;Markus Gerhard.;Jun-ling Ma.;Wei-dong Liu.;Kurt Ulm.;Jian-xi Wang.;Lei Zhang.;Yang Zhang.;Monther Bajbouj.;Lan-fu Zhang.;Ming Li.;Michael Vieth.;Rui-yong Liu.;Michael Quante.;Le-hua Wang.;Stepan Suchanek.;Tong Zhou.;Wei-xiang Guan.;Roland Schmid.;Meinhard Classen.;Wei-cheng You.
来源: Gut. 2016年65卷1期9-18页
To clarify the full range of benefits and adverse consequences of Helicobacter pylori eradication as a strategy for gastric cancer prevention, the community-based intervention trial was launched in Linqu County, China.
3423. In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression.
作者: Kiyotaka Asanuma.;Xiaofang Huo.;Agoston Agoston.;Xi Zhang.;Chunhua Yu.;Edaire Cheng.;Qiuyang Zhang.;Kerry B Dunbar.;Thai H Pham.;David H Wang.;Katsunori Iijima.;Tooru Shimosegawa.;Robert D Odze.;Stuart J Spechler.;Rhonda F Souza.
来源: Gut. 2016年65卷9期1416-26页
Barrett's metaplasia might develop if GORD causes oesophageal squamous cells to convert into columnar cells. Acid and bile exposures upregulate columnar differentiation genes like CDX2 in oesophageal squamous cells, but it is not known if such exposures downregulate squamous differentiation genes like SOX2. In addition to acid and bile, patients with GORD also have high oesophageal concentrations of nitric oxide (NO). This study aims to determine how acid, bile salts and NO affect genes that influence oesophageal cell phenotype.
3424. The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease.
作者: Frederike Schmitz.;Yvonne Kooy-Winkelaar.;Anna-Sophia Wiekmeijer.;Martijn H Brugman.;M Luisa Mearin.;Chris Mulder.;Susana Chuva de Sousa Lopes.;Christine L Mummery.;Frank Jt Staal.;Jeroen van Bergen.;Frits Koning.
来源: Gut. 2016年65卷8期1269-78页
Coeliac disease (CD), a gluten-induced enteropathy, alters the composition and function of duodenal intraepithelial T cells. The intestine also harbours four types of CD3-negative intraepithelial lymphocytes (IELs) with largely unknown function: CD56(-)CD127(-), CD56(-)CD127(+), CD56(+)CD127(-) and CD56(+)CD127(+). Here we aimed to gain insight into the potential function of these innate IELs in health and disease.
3425. PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury.
Endoplasmic reticulum (ER) stress is involved in liver injury, but molecular determinants are largely unknown. This study investigated the role of pleckstrin homology-like domain, family A, member-3 (PHLDA3), in hepatocyte death caused by ER stress and the regulatory basis.
3426. Tailored anti-TNF therapy during pregnancy in patients with IBD: maternal and fetal safety.
作者: A de Lima.;Z Zelinkova.;C van der Ent.;E A P Steegers.;C J van der Woude.
来源: Gut. 2016年65卷8期1261-8页
Antitumour necrosis factor (TNF) during pregnancy in patients with IBD is related to high fetal anti-TNF levels. We evaluated maternal and child safety on discontinuing anti-TNF in the second trimester of pregnancy.
3428. Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer.
作者: Lixia Xu.;Xiaoxing Li.;Muyan Cai.;Jinna Chen.;Xiangchun Li.;William K K Wu.;Wei Kang.;Joanna Tong.;Ka-Fai To.;Xin-Yuan Guan.;Joseph J Y Sung.;Francis K L Chan.;Jun Yu.
来源: Gut. 2016年65卷4期635-46页
Using whole genome sequencing, we identified gene amplification of solute carrier family 12 member 5 (SLC12A5) located at 20q13.12 in colorectal cancer (CRC). We analysed its amplification, overexpression, biological effects and prognostic significance in CRC.
3429. Reliability among central readers in the evaluation of endoscopic findings from patients with Crohn's disease.
作者: Reena Khanna.;Guangyong Zou.;Geert D'Haens.;Paul Rutgeerts.;J W D McDonald.;Marco Daperno.;Brian G Feagan.;William J Sandborn.;Elena Dubcenco.;Larry Stitt.;Margaret K Vandervoort.;Allan Donner.;Allison Luo.;Barrett G Levesque.
来源: Gut. 2016年65卷7期1119-25页
The Crohn's Disease Endoscopic Index of Severity (CDEIS) and Simple Endoscopic Score for Crohn's Disease (SES-CD) are commonly used to assess Crohn's disease (CD) activity; however, neither instrument has been fully validated. We assessed intra-rater and inter-rater reliability of these indices.
3430. The applicability of hepatocellular carcinoma risk prediction scores in a North American patient population with chronic hepatitis B infection.
作者: Mahmoud Abu-Amara.;Orlando Cerocchi.;Gurtej Malhi.;Suraj Sharma.;Colina Yim.;Hemant Shah.;David K Wong.;Harry L A Janssen.;Jordan J Feld.
来源: Gut. 2016年65卷8期1347-58页
Patients with chronic hepatitis B (CHB) infection are at an increased risk of developing hepatocellular carcinoma (HCC). Risk scores have been developed in Asian populations to predict HCC risk over time.
3431. Clinical response to peroral endoscopic myotomy in patients with idiopathic achalasia at a minimum follow-up of 2 years.
作者: Yuki B Werner.;Guido Costamagna.;Lee L Swanström.;Daniel von Renteln.;Pietro Familiari.;Ahmed M Sharata.;Tania Noder.;Guido Schachschal.;Jan F Kersten.;Thomas Rösch.
来源: Gut. 2016年65卷6期899-906页
The recently developed technique for peroral endoscopic myotomy (POEM) has been shown to be effective in several short-term studies. Longer term outcome data are largely non-existent.
3432. Impact of surveillance for Barrett's oesophagus on tumour stage and survival of patients with neoplastic progression.
作者: F Kastelein.;S H van Olphen.;E W Steyerberg.;M C W Spaander.;M J Bruno.; .
来源: Gut. 2016年65卷4期548-54页
Endoscopic surveillance for Barrett's oesophagus (BO) is under discussion given the overall low incidence of neoplastic progression and lack of evidence that it prevents advanced oesophageal adenocarcinoma (OAC). The aim of this study was to evaluate the impact of endoscopic BO surveillance on tumour stage and survival of patients with neoplastic progression.
3433. Cross-immunogenicity: antibodies to infliximab in Remicade-treated patients with IBD similarly recognise the biosimilar Remsima.
作者: Shomron Ben-Horin.;Miri Yavzori.;Itai Benhar.;Ella Fudim.;Orit Picard.;Bella Ungar.;SooYoung Lee.;SungHwan Kim.;Rami Eliakim.;Yehuda Chowers.
来源: Gut. 2016年65卷7期1132-8页
The cross-immunogenicity of the recently approved infliximab-biosimilar Remsima (CT-P13) with the originator drug Remicade is still unknown.
3434. Identification and genetic manipulation of human and mouse oesophageal stem cells.
作者: Youngtae Jeong.;Horace Rhee.;Shanique Martin.;Daniel Klass.;Yuan Lin.;Le Xuan Truong Nguyen.;Weiguo Feng.;Maximilian Diehn.
来源: Gut. 2016年65卷7期1077-86页
Human oesophageal stem cell research is hampered by the lack of an optimal assay system to study self-renewal and differentiation. We aimed to identify and characterise human and mouse oesophageal stem/progenitor cells by establishing 3-dimensional organotypic sphere culture systems for both species.
3436. Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence.
作者: Monika Schaubeck.;Thomas Clavel.;Jelena Calasan.;Ilias Lagkouvardos.;Sven Bastiaan Haange.;Nico Jehmlich.;Marijana Basic.;Aline Dupont.;Mathias Hornef.;Martin von Bergen.;André Bleich.;Dirk Haller.
来源: Gut. 2016年65卷2期225-37页
Dysbiosis of the intestinal microbiota is associated with Crohn's disease (CD). Functional evidence for a causal role of bacteria in the development of chronic small intestinal inflammation is lacking. Similar to human pathology, TNF(deltaARE) mice develop a tumour necrosis factor (TNF)-driven CD-like transmural inflammation with predominant ileal involvement.
3438. Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements: a prospective cohort study.
作者: Raymond Kwok.;Kai Chow Choi.;Grace Lai-Hung Wong.;Yuying Zhang.;Henry Lik-Yuen Chan.;Andrea On-Yan Luk.;Sally She-Ting Shu.;Anthony Wing-Hung Chan.;Ming-Wai Yeung.;Juliana Chung-Ngor Chan.;Alice Pik-Shan Kong.;Vincent Wai-Sun Wong.
来源: Gut. 2016年65卷8期1359-68页
Type 2 diabetes is an important risk factor for non-alcoholic fatty liver disease (NAFLD), but current guidelines provide conflicting recommendations on whether diabetic patients should be screened for NAFLD. We therefore studied the strategy of screening diabetic patients by FibroScan.
3439. Detection of precancerous gastric lesions and gastric cancer through exhaled breath.
作者: Haitham Amal.;Marcis Leja.;Konrads Funka.;Roberts Skapars.;Armands Sivins.;Guntis Ancans.;Inta Liepniece-Karele.;Ilze Kikuste.;Ieva Lasina.;Hossam Haick.
来源: Gut. 2016年65卷3期400-7页
Timely detection of gastric cancer (GC) and the related precancerous lesions could provide a tool for decreasing both cancer mortality and incidence.
3440. Antibodies to adalimumab are associated with future inflammation in Crohn's patients receiving maintenance adalimumab therapy: a post hoc analysis of the Karmiris trial.
作者: Filip Baert.;Venkateswarlu Kondragunta.;Steven Lockton.;Niels Vande Casteele.;Scott Hauenstein.;Sharat Singh.;Konstantinos Karmiris.;Marc Ferrante.;Ann Gils.;Séverine Vermeire.
来源: Gut. 2016年65卷7期1126-31页
Data on immunogenicity to adalimumab (ADL) therapy in patients with IBD is limited. We performed additional analyses on the Karmiris cohort using the homogeneous mobility shift assay (HMSA) focusing on the inter-relationship of serum ADL concentration, antibodies-to-adalimumab (ATA), inflammatory markers and sustained response.
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