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3422. Preliminary report: modulation of parasympathetic nervous system tone influences oesophageal pain hypersensitivity.
作者: Claude Botha.;Adam D Farmer.;Matias Nilsson.;Christina Brock.;Ana D Gavrila.;Asbjørn Mohr Drewes.;Charles H Knowles.;Qasim Aziz.
来源: Gut. 2015年64卷4期611-7页
Autonomic nervous system dysfunction has been implicated in visceral hypersensitivity. However, the specific contribution of the parasympathetic nervous system (PNS) is unclear. We aimed to determine whether physiological and pharmacological manipulation of parasympathetic tone influences the development of hypersensitivity in a validated model of acid-induced oesophageal pain.
3423. Fluorescence virus-guided capturing system of human colorectal circulating tumour cells for non-invasive companion diagnostics.
作者: Kunitoshi Shigeyasu.;Hiroshi Tazawa.;Yuuri Hashimoto.;Yoshiko Mori.;Masahiko Nishizaki.;Hiroyuki Kishimoto.;Takeshi Nagasaka.;Shinji Kuroda.;Yasuo Urata.;Ajay Goel.;Shunsuke Kagawa.;Toshiyoshi Fujiwara.
来源: Gut. 2015年64卷4期627-35页
Molecular-based companion diagnostic tests are being used with increasing frequency to predict their clinical response to various drugs, particularly for molecularly targeted drugs. However, invasive procedures are typically required to obtain tissues for this analysis. Circulating tumour cells (CTCs) are novel biomarkers that can be used for the prediction of disease progression and are also important surrogate sources of cancer cells. Because current CTC detection strategies mainly depend on epithelial cell-surface markers, the presence of heterogeneous populations of CTCs with epithelial and/or mesenchymal characteristics may pose obstacles to the detection of CTCs.
3424. MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB1.
作者: Tae-Su Han.;Keun Hur.;Guorong Xu.;Boram Choi.;Yoshinaga Okugawa.;Yuji Toiyama.;Hiroko Oshima.;Masanobu Oshima.;Hyuk-Joon Lee.;V Narry Kim.;Aaron N Chang.;Ajay Goel.;Han-Kwang Yang.
来源: Gut. 2015年64卷2期203-14页
Gastric cancer (GC) remains difficult to cure due to heterogeneity in a clinical challenge and the molecular mechanisms underlying this disease are complex and not completely understood. Accumulating evidence suggests that microRNAs (miRNAs) play an important role in GC, but the role of specific miRNAs involved in this disease remains elusive. We performed next generation sequencing (NGS)-based whole-transcriptome profiling to discover GC-specific miRNAs, followed by functional validation of results.
3427. Early endoscopic, laboratory and clinical predictors of poor disease course in paediatric ulcerative colitis.
作者: Amir Schechter.;Christopher Griffiths.;Juan Cristóbal Gana.;Ron Shaoul.;Raanan Shamir.;Eyal Shteyer.;Tali Bdolah-Abram.;Oren Ledder.;Dan Turner.
来源: Gut. 2015年64卷4期580-8页
Data to support treatment algorithms in ambulatory paediatric UC are scarce. We aimed to explore the 1 year outcome in an inception cohort of paediatric UC patients and to identify early predictors of good outcome that might serve as short term treatment targets.
3428. Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C.
作者: Fei Xiao.;Isabel Fofana.;Christine Thumann.;Laurent Mailly.;Roxane Alles.;Eric Robinet.;Nicolas Meyer.;Mickaël Schaeffer.;François Habersetzer.;Michel Doffoël.;Pieter Leyssen.;Johan Neyts.;Mirjam B Zeisel.;Thomas F Baumert.
来源: Gut. 2015年64卷3期483-94页
Although direct-acting antiviral agents (DAAs) have markedly improved the outcome of treatment in chronic HCV infection, there continues to be an unmet medical need for improved therapies in difficult-to-treat patients as well as liver graft infection. Viral entry is a promising target for antiviral therapy.
3429. The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation.
作者: Marco Genua.;Silvia D'Alessio.;Javier Cibella.;Alessandro Gandelli.;Emanuela Sala.;Carmen Correale.;Antonino Spinelli.;Vincenzo Arena.;Alberto Malesci.;Sergio Rutella.;Victoria A Ploplis.;Stefania Vetrano.;Silvio Danese.
来源: Gut. 2015年64卷4期589-600页
Inflammation plays crucial roles in the pathogenesis of several chronic inflammatory disorders, including Crohn's disease (CD) and UC, the two major forms of IBD. The urokinase plasminogen activator receptor (uPAR) exerts pleiotropic functions over the course of both physiological and pathological processes. uPAR not only has a key role in fibrinolysis but also modulates the development of protective immunity. Additionally, uPAR supports extracellular matrix degradation and regulates cell migration, adhesion and proliferation, thus influencing the development of inflammatory and immune responses. This study aimed to evaluate the role of uPAR in the pathogenesis of IBD.
3430. Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats.
作者: Marc Mejias.;Laura Coch.;Annalisa Berzigotti.;Ester Garcia-Pras.;Javier Gallego.;Jaime Bosch.;Mercedes Fernandez.
来源: Gut. 2015年64卷4期657-66页
Antiangiogenic strategies have been proposed as a promising new approach for the therapy of portal hypertension and chronic liver disease. Pigment epithelium-derived factor (PEDF) is a powerful endogenous angiogenesis inhibitor whose role in portal hypertension remains unknown. Therefore, we aimed at determining the involvement of PEDF in cirrhotic portal hypertension and the therapeutic efficacy of its supplementation.
3432. Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.
作者: Garima Juyal.;Sapna Negi.;Ajit Sood.;Aditi Gupta.;Pushplata Prasad.;Sabyasachi Senapati.;Jacques Zaneveld.;Shalini Singh.;Vandana Midha.;Suzanne van Sommeren.;Rinse K Weersma.;Jurg Ott.;Sanjay Jain.;Ramesh C Juyal.;B K Thelma.
来源: Gut. 2015年64卷4期571-9页
Over 100 ulcerative colitis (UC) loci have been identified by genome-wide association studies (GWASs) primarily in Caucasians (CEUs). Many of them have weak effects on disease susceptibility, and the bulk of the heritability cannot be ascribed to these loci. Very little is known about the genetic background of UC in non-CEU groups. Here we report the first GWAS on UC in a genetically distinct north Indian (NI) population.
3433. Galectin-3 regulates hepatic progenitor cell expansion during liver injury.
作者: Wei-Chen Hsieh.;Alison C Mackinnon.;Wei-Yu Lu.;Jonathan Jung.;Luke Boulter.;Neil C Henderson.;Kenneth J Simpson.;Baukje Schotanus.;Davina Wojtacha.;Tom G Bird.;Claire N Medine.;David C Hay.;Tariq Sethi.;John P Iredale.;Stuart J Forbes.
来源: Gut. 2015年64卷2期312-21页
Following chronic liver injury or when hepatocyte proliferation is impaired, ductular reactions containing hepatic progenitor cells (HPCs) appear in the periportal regions and can regenerate the liver parenchyma. HPCs exist in a niche composed of myofibroblasts, macrophages and laminin matrix. Galectin-3 (Gal-3) is a β-galactoside-binding lectin that binds to laminin and is expressed in injured liver in mice and humans.
3434. Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in IBS, UC and healthy volunteers.
作者: Julia Schmid.;Jost Langhorst.;Florian Gaß.;Nina Theysohn.;Sven Benson.;Harald Engler.;Elke R Gizewski.;Michael Forsting.;Sigrid Elsenbruch.
来源: Gut. 2015年64卷3期418-27页
Understanding the neural circuitry of placebo analgesia in the context of visceral pain is increasingly important given evidence of clinical benefit of placebo treatment in IBS. This functional MRI study addressed placebo analgesia in IBS, UC and healthy control (HC) volunteers.
3435. Treatment cessation of entecavir in Asian patients with hepatitis B e antigen negative chronic hepatitis B: a multicentre prospective study.
作者: Wai-Kay Seto.;Aric Josun Hui.;Vincent Wai-Sun Wong.;Grace Lai-Hung Wong.;Kevin Sze-Hang Liu.;Ching-Lung Lai.;Man-Fung Yuen.;Henry Lik-Yuen Chan.
来源: Gut. 2015年64卷4期667-72页
The off-treatment durability of nucleos(t)ide analogue therapy in Asian hepatitis B e antigen (HBeAg) negative chronic hepatitis B (CHB) and the role of hepatitis B surface antigen (HBsAg) levels in predicting off-treatment durability has not been well investigated.
3436. Outcome measures for clinical trials in paediatric IBD: an evidence-based, expert-driven practical statement paper of the paediatric ECCO committee.
作者: Frank M Ruemmele.;Jeffrey S Hyams.;Anthony Otley.;Anne Griffiths.;Kaija-Leena Kolho.;Jorge Amil Dias.;Arie Levine.;Johanna C Escher.;Jan Taminiau.;Gabor Veres.;Jean-Frederic Colombel.;Séverine Vermeire.;David C Wilson.;Dan Turner.
来源: Gut. 2015年64卷3期438-46页
Although paediatric-onset IBD is becoming more common, few medications have a registered paediatric indication. There are multiple hurdles to performing clinical trials in children, emphasising the importance of choosing an appropriate outcome measure, which can facilitate enrolment, and thereby also drug approval. The aim of this consensus statement is to highlight paediatric specific issues and key factors critical for the optimal conduct of paediatric IBD trials.
3437. Reliable prediction of clinical outcome in patients with chronic HCV infection and compensated advanced hepatic fibrosis: a validated model using objective and readily available clinical parameters.
作者: Adriaan J van der Meer.;Bettina E Hansen.;Giovanna Fattovich.;Jordan J Feld.;Heiner Wedemeyer.;Jean-François Dufour.;Frank Lammert.;Andres Duarte-Rojo.;Michael P Manns.;Donatella Ieluzzi.;Stefan Zeuzem.;W Peter Hofmann.;Robert J de Knegt.;Bart J Veldt.;Harry L A Janssen.
来源: Gut. 2015年64卷2期322-31页
Reliable tools to predict long-term outcome among patients with well compensated advanced liver disease due to chronic HCV infection are lacking.
3438. Colorectal cancer screening uptake over three biennial invitation rounds in the English bowel cancer screening programme.
作者: Siu Hing Lo.;Stephen Halloran.;Julia Snowball.;Helen Seaman.;Jane Wardle.;Christian von Wagner.
来源: Gut. 2015年64卷2期282-91页
To examine patterns of colorectal cancer (CRC) screening uptake over three biennial invitation rounds in the National Health Service (NHS) Bowel Cancer Screening Programme (BCSP) in England.
3439. Pepsin in saliva for the diagnosis of gastro-oesophageal reflux disease.
作者: Jamal O Hayat.;Shirley Gabieta-Somnez.;Etsuro Yazaki.;Jin-Yong Kang.;Andrew Woodcock.;Peter Dettmar.;Jerry Mabary.;Charles H Knowles.;Daniel Sifrim.
来源: Gut. 2015年64卷3期373-80页
Current diagnostic methods for gastro-oesophageal reflux disease (GORD) have moderate sensitivity/specificity and can be invasive and expensive. Pepsin detection in saliva has been proposed as an 'office-based' method for GORD diagnosis. The aims of this study were to establish normal values of salivary pepsin in healthy asymptomatic subjects and to determine its value to discriminate patients with reflux-related symptoms (GORD, hypersensitive oesophagus (HO)) from functional heartburn (FH).
3440. Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide.
作者: Aline Dupont.;Yani Kaconis.;Ines Yang.;Thorben Albers.;Sabrina Woltemate.;Lena Heinbockel.;Mats Andersson.;Sebastian Suerbaum.;Klaus Brandenburg.;Mathias W Hornef.
来源: Gut. 2015年64卷2期222-32页
Antimicrobial peptides (AMP) provide protection from infection by pathogenic microorganisms and restrict bacterial growth at epithelial surfaces to maintain mucosal homeostasis. In addition, they exert a significant anti-inflammatory activity. Here we analysed the anatomical distribution and biological activity of an orally administered AMP in the context of bacterial infection and host-microbial homeostasis.
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