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3401. Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection.
作者: Karen Fitzmaurice.;Jacob Hurst.;Megan Dring.;Andri Rauch.;Paul J McLaren.;Huldrych F Günthard.;Clair Gardiner.;Paul Klenerman.; .; .
来源: Gut. 2015年64卷5期813-9页
Chronic HCV infection is a leading cause of liver-related morbidity globally. The innate and adaptive immune responses are thought to be important in determining viral outcomes. Polymorphisms associated with the IFNL3 (IL28B) gene are strongly associated with spontaneous clearance and treatment outcomes.
3402. Long-term adenoma recurrence following wide-field endoscopic mucosal resection (WF-EMR) for advanced colonic mucosal neoplasia is infrequent: results and risk factors in 1000 cases from the Australian Colonic EMR (ACE) study.
作者: Alan Moss.;Stephen J Williams.;Luke F Hourigan.;Gregor Brown.;William Tam.;Rajvinder Singh.;Simon Zanati.;Nicholas G Burgess.;Rebecca Sonson.;Karen Byth.;Michael J Bourke.
来源: Gut. 2015年64卷1期57-65页
Wide-field endoscopic mucosal resection (WF-EMR) is an alternative to surgery for treatment of advanced colonic mucosal neoplasia up to 120 mm in size, but has been criticised for its potentially high recurrence rates. We aimed to quantify recurrence at 4 months (early) and 16 months (late) following successful WF-EMR and identify its risk factors and clinical significance.
3403. Gene expression alterations in ulcerative colitis patients after restorative proctocolectomy extend to the small bowel proximal to the pouch.
作者: Henit Yanai.;Shay Ben-Shachar.;Liran Baram.;Hofit Elad.;Gilad Gitstein.;Eli Brazowski.;Hagit Tulchinsky.;Metsada Pasmanik-Chor.;Iris Dotan.
来源: Gut. 2015年64卷5期756-64页
To evaluate molecular profiles in the small bowel (SB) mucosa proximal to the pouch in ulcerative colitis (UC) patients after pouch surgery.
3404. Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis.
作者: Carlos J Pirola.;Tomas Fernández Gianotti.;Gustavo O Castaño.;Pablo Mallardi.;Julio San Martino.;María Mora Gonzalez Lopez Ledesma.;Diego Flichman.;Faridodin Mirshahi.;Arun J Sanyal.;Silvia Sookoian.
来源: Gut. 2015年64卷5期800-12页
We used a screening strategy of global serum microRNA (miRNA) profiling, followed by a second stage of independent replication and exploration of liver expression of selected miRNAs to study: (1) the circulating miRNA signature associated with non-alcoholic fatty liver disease (NAFLD) progression and predictive power, (2) the role of miRNAs in disease biology and (3) the association between circulating miRNAs and features of the metabolic syndrome.
3406. Colon capsule versus CT colonography in patients with incomplete colonoscopy: a prospective, comparative trial.
作者: Cristiano Spada.;Cesare Hassan.;Brunella Barbaro.;Franco Iafrate.;Paola Cesaro.;Lucio Petruzziello.;Leonardo Minelli Grazioli.;Carlo Senore.;Gabriella Brizi.;Isabella Costamagna.;Giuseppe Alvaro.;Marcella Iannitti.;Marco Salsano.;Maria Ciolina.;Andrea Laghi.;Lorenzo Bonomo.;Guido Costamagna.
来源: Gut. 2015年64卷2期272-81页
In case of incomplete colonoscopy, several radiologic methods have traditionally been used, but more recently, capsule endoscopy was also shown to be accurate. Aim of this study was to compare colon capsule endoscopy (CCE) and CT colonography (CTC) in a prospective cohort of patients with incomplete colonoscopy.
3407. IL-9 and its receptor are predominantly involved in the pathogenesis of UC.
作者: Nancy Nalleweg.;Mircea Teodor Chiriac.;Eva Podstawa.;Christian Lehmann.;Tilman T Rau.;Raja Atreya.;Ekaterina Krauss.;Gheorghe Hundorfean.;Stefan Fichtner-Feigl.;Arndt Hartmann.;Christoph Becker.;Jonas Mudter.
来源: Gut. 2015年64卷5期743-55页
Several pathogenic roles attributed over the past two decades to either T helper (Th)1 or Th2 cells are increasingly becoming associated with interleukin (IL)-17 and most recently IL-9 signalling. However, the implication of IL-9 in IBD has not been addressed so far.
3408. Small intestinal permeability in patients with eosinophilic oesophagitis during active phase and remission.
作者: David A Katzka.;Debra M Geno.;Hilary E Blair.;Jesse L Lamsam.;Jeffrey A Alexander.;Michael Camilleri.
来源: Gut. 2015年64卷4期538-43页
Eosinophilic oesophagitis (EoE) is presumed to be an isolated oesophageal disease; yet other allergic diseases associated with eosinophilic infiltration of target tissues, such as asthma and eczema, show perturbed functions of other sites that may be involved in the diathesis of allergy modulation.
3409. Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer.
作者: Jun Yu.;William K K Wu.;Xiangchun Li.;Jun He.;Xiao-Xing Li.;Simon S M Ng.;Chang Yu.;Zhibo Gao.;Jie Yang.;Miao Li.;Qiaoxiu Wang.;Qiaoyi Liang.;Yi Pan.;Joanna H Tong.;Ka F To.;Nathalie Wong.;Ning Zhang.;Jie Chen.;Youyong Lu.;Paul B S Lai.;Francis K L Chan.;Yingrui Li.;Hsiang-Fu Kung.;Huanming Yang.;Jun Wang.;Joseph J Y Sung.
来源: Gut. 2015年64卷4期636-45页
Characterisation of colorectal cancer (CRC) genomes by next-generation sequencing has led to the discovery of novel recurrently mutated genes. Nevertheless, genomic data has not yet been used for CRC prognostication.
3410. CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis.
作者: Yoku Hayakawa.;Guangchun Jin.;Hongshan Wang.;Xiaowei Chen.;Christoph B Westphalen.;Samuel Asfaha.;Bernhard W Renz.;Hiroshi Ariyama.;Zinaida A Dubeykovskaya.;Yoshihiro Takemoto.;Yoomi Lee.;Ashlesha Muley.;Yagnesh Tailor.;Duan Chen.;Sureshkumar Muthupalani.;James G Fox.;Arthur Shulkes.;Daniel L Worthley.;Shigeo Takaishi.;Timothy C Wang.
来源: Gut. 2015年64卷4期544-53页
Progastrin is the incompletely cleaved precursor of gastrin that is secreted by G-cells in the gastric antrum. Both gastrin and progastrin bind to the CCK2 receptor (Cckbr or CCK2R) expressed on a subset of gastric epithelial cells. Little is known about how gastrin peptides and CCK2R regulate gastric stem cells and carcinogenesis. Interconversion among progenitors in the intestine is documented, but the mechanisms by which this occurs are poorly defined.
3413. The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease.
作者: M Olivares.;A Neef.;G Castillejo.;G De Palma.;V Varea.;A Capilla.;F Palau.;E Nova.;A Marcos.;I Polanco.;C Ribes-Koninckx.;L Ortigosa.;L Izquierdo.;Y Sanz.
来源: Gut. 2015年64卷3期406-17页
Intestinal dysbiosis has been associated with coeliac disease (CD), but whether the alterations are cause or consequence of the disease is unknown. This study investigated whether the human leukocyte antigen (HLA)-DQ2 genotype is an independent factor influencing the early gut microbiota composition of healthy infants at family risk of CD.
3414. Endothelial progenitors promote hepatocarcinoma intrahepatic metastasis through monocyte chemotactic protein-1 induction of microRNA-21.
作者: Yu-Tsung Shih.;Mei-Cun Wang.;Jing Zhou.;Hsin-Hsin Peng.;Ding-Yu Lee.;Jeng-Jiann Chiu.
来源: Gut. 2015年64卷7期1132-47页
Endothelial progenitor cells (EPCs) circulate with increased numbers in the peripheral blood of patients with highly-vascularised hepatocellular carcinoma (HCC) and contribute to angiogenesis and neovascularisation. We hypothesised that angiogenic EPCs, that is, colony forming unit-endothelial cells (CFU-ECs), and outgrowth EPCs, that is, endothelial colony-forming cells, may exert paracrine effects on the behaviours and metastatic capacities of human hepatoma cells.
3416. Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis.
作者: Jef Verbeek.;Matthias Lannoo.;Eija Pirinen.;Dongryeol Ryu.;Pieter Spincemaille.;Ingrid Vander Elst.;Petra Windmolders.;Karin Thevissen.;Bruno P A Cammue.;Jos van Pelt.;Sabine Fransis.;Peter Van Eyken.;Chantal Ceuterick-De Groote.;Paul P Van Veldhoven.;Pierre Bedossa.;Frederik Nevens.;Johan Auwerx.;David Cassiman.
来源: Gut. 2015年64卷4期673-83页
No therapy for non-alcoholic steatohepatitis (NASH) has been approved so far. Roux-en-y gastric bypass (RYGB) is emerging as a therapeutic option, although its effect on NASH and related hepatic molecular pathways is unclear from human studies. We studied the effect of RYGB on pre-existent NASH and hepatic mitochondrial dysfunction-a key player in NASH pathogenesis-in a novel diet-induced mouse model nicely mimicking human disease.
3417. Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect.
Commensal bacteria and innate immunity play a major role in the development of colorectal cancer (CRC). We propose that selected commensals polarise colon macrophages to produce endogenous mutagens that initiate chromosomal instability (CIN), lead to expression of progenitor and tumour stem cell markers, and drive CRC through a bystander effect.
3418. Protective effects of Fc-fused PD-L1 on two different animal models of colitis.
作者: Mi-Young Song.;Chun-Pyo Hong.;Seong Jeong Park.;Jung-Hwan Kim.;Bo-Gie Yang.;Yunji Park.;Sae Won Kim.;Kwang Soon Kim.;Ji Yeung Lee.;Seung-Woo Lee.;Myoung Ho Jang.;Young-Chul Sung.
来源: Gut. 2015年64卷2期260-71页
Programmed death-ligand 1 (PD-L1) has been shown to negatively regulate immune responses via its interaction with PD-1 receptor. In this study, we investigated the effects of PD-L1-Fc treatment on intestinal inflammation using two murine models of inflammatory colitis induced by dextran sulfate sodium (DSS) and T-cell transfer.
3419. Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice.
作者: J D Coombes.;M Swiderska-Syn.;L Dollé.;D Reid.;B Eksteen.;L Claridge.;M A Briones-Orta.;S Shetty.;Y H Oo.;A Riva.;S Chokshi.;S Papa.;Z Mi.;P C Kuo.;R Williams.;A Canbay.;D H Adams.;A M Diehl.;L A van Grunsven.;S S Choi.;W K Syn.
来源: Gut. 2015年64卷7期1120-31页
Chronic liver injury triggers a progenitor cell repair response, and liver fibrosis occurs when repair becomes deregulated. Previously, we reported that reactivation of the hedgehog pathway promotes fibrogenic liver repair. Osteopontin (OPN) is a hedgehog-target, and a cytokine that is highly upregulated in fibrotic tissues, and regulates stem-cell fate. Thus, we hypothesised that OPN may modulate liver progenitor cell response, and thereby, modulate fibrotic outcomes. We further evaluated the impact of OPN-neutralisation on murine liver fibrosis.
3420. Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associated Escherichia coli colonisation.
作者: Jérémy Denizot.;Alexis Desrichard.;Allison Agus.;Nancy Uhrhammer.;Nicolas Dreux.;Valérie Vouret-Craviari.;Paul Hofman.;Arlette Darfeuille-Michaud.;Nicolas Barnich.
来源: Gut. 2015年64卷3期428-37页
Adherent-invasive Escherichia coli (AIEC) are abnormally predominant on Crohn's disease (CD) ileal mucosa. AIEC strains adhere to enterocytes via interaction between type 1 pili and CEACAM6 receptors abnormally expressed on CD ileal mucosa, leading to gut inflammation. We analysed whether epigenetic mechanisms are involved in the upregulation of CEACAM6 expression in intestinal epithelial cells (IECs).
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