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3401. Serum viral duplex-linear DNA proportion increases with the progression of liver disease in patients infected with HBV.
作者: Xing-Liang Zhao.;Jian-Rong Yang.;Sheng-Zhang Lin.;Hui Ma.;Fang Guo.;Rui-Feng Yang.;Heng-Hui Zhang.;Jin-Chao Han.;Lai Wei.;Xiao-Ben Pan.
来源: Gut. 2016年65卷3期502-11页
HBV has two forms of genomic DNA, relaxed-circular DNA (rcDNA) and duplex-linear DNA (dlDNA). Compared to rcDNA, dlDNA has been demonstrated to integrate more frequently into host cellular chromosomes, which may have oncogenic consequences. However, the dlDNA proportion relative to total HBV DNA and its clinical significance in patients remain to be investigated.
3402. Antibiotics promote inflammation through the translocation of native commensal colonic bacteria.
作者: Kathryn A Knoop.;Keely G McDonald.;Devesha H Kulkarni.;Rodney D Newberry.
来源: Gut. 2016年65卷7期1100-9页
Antibiotic use is associated with an increased risk of developing multiple inflammatory disorders, which in turn are linked to alterations in the intestinal microbiota. How these alterations in the intestinal microbiota translate into an increased risk for inflammatory responses is largely unknown. Here we investigated whether and how antibiotics promote inflammation via the translocation of live native gut commensal bacteria.
3403. A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection.
作者: David Y Zhang.;Nicolas Goossens.;Jinsheng Guo.;Ming-Chao Tsai.;Hsin-I Chou.;Civan Altunkaynak.;Angelo Sangiovanni.;Massimo Iavarone.;Massomo Colombo.;Masahiro Kobayashi.;Hiromitsu Kumada.;Augusto Villanueva.;Josep M Llovet.;Yujin Hoshida.;Scott L Friedman.
来源: Gut. 2016年65卷10期1754-64页
We used an informatics approach to identify and validate genes whose expression is unique to hepatic stellate cells and assessed the prognostic capability of their expression in cirrhosis.
3404. Monocyte-derived hepatocyte-like cells for causality assessment of idiosyncratic drug-induced liver injury.
Idiosyncratic drug-induced liver injury (iDILI) is a frequent cause of acute liver injury and a serious problem in late stage drug-development. Its diagnosis is one of the most challenging in hepatology, since it is done by exclusion and relies on expert opinion. Until now no reliable in vitro test exists to support the diagnosis of iDILI. In some instances it is impossible to determine the causative drug in polymedicated patients.
3405. Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease.
作者: E Quévrain.;M A Maubert.;C Michon.;F Chain.;R Marquant.;J Tailhades.;S Miquel.;L Carlier.;L G Bermúdez-Humarán.;B Pigneur.;O Lequin.;P Kharrat.;G Thomas.;D Rainteau.;C Aubry.;N Breyner.;C Afonso.;S Lavielle.;J-P Grill.;G Chassaing.;J M Chatel.;G Trugnan.;R Xavier.;P Langella.;H Sokol.;P Seksik.
来源: Gut. 2016年65卷3期415-425页
Crohn's disease (CD)-associated dysbiosis is characterised by a loss of Faecalibacterium prausnitzii, whose culture supernatant exerts an anti-inflammatory effect both in vitro and in vivo. However, the chemical nature of the anti-inflammatory compounds has not yet been determined.
3406. Management of acute-on-chronic liver failure: rotational thromboelastometry may reduce substitution of coagulation factors in liver cirrhosis.
作者: Sotiria Bedreli.;Jan-Peter Sowa.;Guido Gerken.;Fuat Hakan Saner.;Ali Canbay.
来源: Gut. 2016年65卷2期357-8页 3407. Serum macrophage inflammatory protein 3α levels predict the severity of HBV-related acute-on-chronic liver failure.
作者: Jiaojiao Xin.;Wenchao Ding.;Shaorui Hao.;Xin Chen.;Jianing Zhang.;Longyan Jiang.;Qian Zhou.;Dongyan Shi.;Liyuan Zhang.;Xiaowei Xu.;Hongcui Cao.;Lanjuan Li.;Jun Li.
来源: Gut. 2016年65卷2期355-7页 3408. EUS-guided gall bladder drainage with a lumen-apposing metal stent: a prospective long-term evaluation.
作者: Daisy Walter.;Anthony Y Teoh.;Takao Itoi.;Manuel Pérez-Miranda.;Alberto Larghi.;Andres Sanchez-Yague.;Peter D Siersema.;Frank P Vleggaar.
来源: Gut. 2016年65卷1期6-8页 3409. BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling.
作者: Bettina C Urban.;Tracey J Collard.;Catherine J Eagle.;Samantha L Southern.;Alexander Greenhough.;Maryam Hamdollah-Zadeh.;Anil Ghosh.;Richard Poulsom.;Christos Paraskeva.;Andrew Silver.;Ann C Williams.
来源: Gut. 2016年65卷7期1151-64页
Colorectal cancer remains the fourth most common cause of cancer-related mortality worldwide. Here we investigate the role of nuclear factor-κB (NF-κB) co-factor B-cell CLL/lymphoma 3 (BCL-3) in promoting colorectal tumour cell survival.
3410. POU2F2-oriented network promotes human gastric cancer metastasis.
作者: Si-Meng Wang.;Jun Tie.;Wen-Lan Wang.;Si-Jun Hu.;Ji-Peng Yin.;Xiao-Fang Yi.;Zu-Hong Tian.;Xiang-Yuan Zhang.;Meng-Bin Li.;Zeng-Shan Li.;Yong-Zhan Nie.;Kai-Chun Wu.;Dai-Ming Fan.
来源: Gut. 2016年65卷9期1427-38页
Aberrant upregulation of POU2F2 expression has been discovered in metastatic gastric cancer (GC). However, the mechanisms underlying the aberrant upregulation and the potential functions of POU2F2 remain uncertain.
3411. Prediction of oesophageal variceal bleeding by measuring spleen stiffness in patients with liver cirrhosis.
作者: Yoshitaka Takuma.;Kazuhiro Nouso.;Youichi Morimoto.;Junko Tomokuni.;Akiko Sahara.;Hiroyuki Takabatake.;Akira Doi.;Kazuhiro Matsueda.;Hiroshi Yamamoto.
来源: Gut. 2016年65卷2期354-5页 3412. Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease.
作者: Anna Janina Engstler.;Tobias Aumiller.;Christian Degen.;Marion Dürr.;Eva Weiss.;Ina Barbara Maier.;Jörn Markus Schattenberg.;Cheng Jun Jin.;Cathrin Sellmann.;Ina Bergheim.
来源: Gut. 2016年65卷9期1564-71页
Increased fasting blood ethanol levels, suggested to stem from an increased endogenous ethanol synthesis in the GI tract, are discussed to be critical in the development of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to further delineate the mechanisms involved in the elevated blood ethanol levels found in patients with NAFLD.
3413. Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study.
作者: Amir Zarrinpar.;Shakti Gupta.;Mano R Maurya.;Shankar Subramaniam.;Rohit Loomba.
来源: Gut. 2016年65卷9期1546-54页
In the setting where two individuals are genetically similar, epigenetic mechanisms could account for discordance in the presence or absence of non-alcoholic fatty liver disease (NAFLD). This study investigated if serum microRNAs (miRs) could explain discordance in NAFLD.
3414. Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer.
作者: Michael Kloth.;Vanessa Ruesseler.;Christoph Engel.;Katharina Koenig.;Martin Peifer.;Erika Mariotti.;Helen Kuenstlinger.;Alexandra Florin.;Ursula Rommerscheidt-Fuss.;Ulrike Koitzsch.;Claudia Wodtke.;Frank Ueckeroth.;Stefanie Holzapfel.;Stefan Aretz.;Peter Propping.;Markus Loeffler.;Sabine Merkelbach-Bruse.;Margarete Odenthal.;Nicolaus Friedrichs.;Lukas Carl Heukamp.;Thomas Zander.;Reinhard Buettner.
来源: Gut. 2016年65卷8期1296-305页
Microsatellite instability (MSI) is detected in approximately 15% of all colorectal cancers (CRC) and virtually in all cases with Lynch syndrome. The MSI phenotype is caused by dysfunctional mismatch repair (MMR) and leads to accumulation of DNA replication errors. Sporadic MSI CRC often harbours BRAF(V600E); however, no consistent data exist regarding targeted treatment approaches in BRAF(wt) MSI CRC.
3415. Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer.
作者: Chenzhang Shi.;Yongzhi Yang.;Yang Xia.;Yoshinaga Okugawa.;Jun Yang.;Yong Liang.;Hongqi Chen.;Peng Zhang.;Feng Wang.;Huazhong Han.;Wen Wu.;Renyuan Gao.;Christoph Gasche.;Huanlong Qin.;Yanlei Ma.;Ajay Goel.
来源: Gut. 2016年65卷9期1470-81页
miR-21 was found to be overexpressed in the colon tissues and serum of patients with UC and colorectal cancer (CRC); however, the exact roles of miR-21 in colitis-associated CRC remain unclear. The aim of our study was to investigate the biological mechanisms of miR-21 in colitis-associated colon cancer (CAC).
3416. Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α.
作者: Yanlei Ma.;Yongzhi Yang.;Feng Wang.;Mary-Pat Moyer.;Qing Wei.;Peng Zhang.;Zhe Yang.;Weijie Liu.;Huizhen Zhang.;Niwei Chen.;Hua Wang.;Huamin Wang.;Huanlong Qin.
来源: Gut. 2016年65卷9期1494-504页
Long non-coding RNAs (lncRNAs) are emerging as key molecules in cancers, yet their potential molecular mechanisms are not well understood. The objective of this study is to examine the expression and functions of lncRNAs in the development of colorectal cancer (CRC).
3417. Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C.
作者: Thomas Müller.;Insha Rasool.;Peter Heinz-Erian.;Eva Mildenberger.;Christian Hülstrunk.;Andreas Müller.;Laurent Michaud.;Bart G P Koot.;Antje Ballauff.;Julia Vodopiutz.;Stefan Rosipal.;Britt-Sabina Petersen.;Andre Franke.;Irene Fuchs.;Heiko Witt.;Heinz Zoller.;Andreas R Janecke.;Sandhya S Visweswariah.
来源: Gut. 2016年65卷8期1306-13页
Congenital sodium diarrhoea (CSD) refers to a form of secretory diarrhoea with intrauterine onset and high faecal losses of sodium without congenital malformations. The molecular basis for CSD remains unknown. We clinically characterised a cohort of infants with CSD and set out to identify disease-causing mutations by genome-wide genetic testing.
3418. Adolescent body mass index and erythrocyte sedimentation rate in relation to colorectal cancer risk.
作者: Elizabeth D Kantor.;Ruzan Udumyan.;Lisa B Signorello.;Edward L Giovannucci.;Scott Montgomery.;Katja Fall.
来源: Gut. 2016年65卷8期1289-95页
Adult obesity and inflammation have been associated with risk of colorectal cancer (CRC); however, less is known about how adolescent body mass index (BMI) and inflammation, as measured by erythrocyte sedimentation rate (ESR), relate to CRC risk. We sought to evaluate these associations in a cohort of 239 658 Swedish men who underwent compulsory military enlistment examinations in late adolescence (ages 16-20 years).
3419. Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up.
作者: Robert V Bryant.;Daniel C Burger.;Joseph Delo.;Alissa J Walsh.;Sally Thomas.;Axel von Herbay.;Otto C Buchel.;Lydia White.;Oliver Brain.;Satish Keshav.;Bryan F Warren.;Simon P L Travis.
来源: Gut. 2016年65卷3期408-14页
Endoscopic mucosal healing is an established treatment target for UC, yet the value of achieving histological remission remains unclear.
3420. Higher plasma motilin levels in obese patients decrease after Roux-en-Y gastric bypass surgery and regulate hunger.
作者: E Deloose.;P Janssen.;M Lannoo.;B Van der Schueren.;I Depoortere.;J Tack.
来源: Gut. 2016年65卷7期1110-8页
Motilin-induced phase III contractions of the migrating motor complex (MMC) signal hunger in healthy volunteers. The current aim was to study the role of motilin as a hunger-inducing factor in obese patients and to evaluate the effect of Roux-en-Y gastric bypass (RYGB) surgery on plasma motilin levels and hunger scores.
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