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3381. Intestinal steroidogenesis controls PPARγ expression in the colon and is impaired during ulcerative colitis.
作者: Guillaume Bouguen.;Audrey Langlois.;Madjid Djouina.;Julien Branche.;Dine Koriche.;Edmone Dewaeles.;Alice Mongy.;Johan Auwerx.;Jean-Frederic Colombel.;Pierre Desreumaux.;Laurent Dubuquoy.;Benjamin Bertin.
来源: Gut. 2015年64卷6期901-10页
Immune tolerance breakdown during UC involves the peroxisome proliferator-activated receptor-γ (PPARγ), a key factor in mucosal homoeostasis and the therapeutic target of 5-aminosalycilates, which expression is impaired during UC. Here we assess the impact of glucocorticoids (GCs) on PPARγ expression, focusing especially on extra-adrenal cortisol production by colonic epithelial cells (CECs).
3382. Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
作者: M V Machado.;G A Michelotti.;T de Almeida Pereira.;J Boursier.;L Kruger.;M Swiderska-Syn.;G Karaca.;G Xie.;C D Guy.;B Bohinc.;K R Lindblom.;E Johnson.;S Kornbluth.;A M Diehl.
来源: Gut. 2015年64卷7期1148-57页
Caspase-2 is an initiator caspase involved in multiple apoptotic pathways, particularly in response to specific intracellular stressors (eg, DNA damage, ER stress). We recently reported that caspase-2 was pivotal for the induction of cell death triggered by excessive intracellular accumulation of long-chain fatty acids, a response known as lipoapoptosis. The liver is particularly susceptible to lipid-induced damage, explaining the pandemic status of non-alcoholic fatty liver disease (NAFLD). Progression from NAFLD to non-alcoholic steatohepatitis (NASH) results, in part, from hepatocyte apoptosis and consequential paracrine-mediated fibrogenesis. We evaluated the hypothesis that caspase-2 promotes NASH-related cirrhosis.
3383. Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.
作者: Na-Yu Chia.;Niantao Deng.;Kakoli Das.;Dachuan Huang.;Longyu Hu.;Yansong Zhu.;Kiat Hon Lim.;Ming-Hui Lee.;Jeanie Wu.;Xin Xiu Sam.;Gek San Tan.;Wei Keat Wan.;Willie Yu.;Anna Gan.;Angie Lay Keng Tan.;Su-Ting Tay.;Khee Chee Soo.;Wai Keong Wong.;Lourdes Trinidad M Dominguez.;Huck-Hui Ng.;Steve Rozen.;Liang-Kee Goh.;Bin-Tean Teh.;Patrick Tan.
来源: Gut. 2015年64卷5期707-19页
Gastric cancer (GC) is a deadly malignancy for which new therapeutic strategies are needed. Three transcription factors, KLF5, GATA4 and GATA6, have been previously reported to exhibit genomic amplification in GC. We sought to validate these findings, investigate how these factors function to promote GC, and identify potential treatment strategies for GCs harbouring these amplifications.
3384. Surveillance in patients with long-segment Barrett's oesophagus: a cost-effectiveness analysis.
作者: F Kastelein.;S van Olphen.;E W Steyerberg.;M Sikkema.;M C W Spaander.;C W N Looman.;E J Kuipers.;P D Siersema.;M J Bruno.;E W de Bekker-Grob.; .
来源: Gut. 2015年64卷6期864-71页
Surveillance is recommended for Barrett's oesophagus (BO) to detect early oesophageal adenocarcinoma (OAC). The aim of this study was to evaluate the cost-effectiveness of surveillance.
3385. Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.
作者: Jaroslaw Cendrowski.;Víctor J Sánchez-Arévalo Lobo.;Matthias Sendler.;Antonio Salas.;Jens-Peter Kühn.;Xavier Molero.;Rikiro Fukunaga.;Julia Mayerle.;Markus M Lerch.;Francisco X Real.
来源: Gut. 2015年64卷6期937-47页
Pancreatic acinar cell maturation is dependent on the activity of the pancreas transcription factor 1 (PTF1) complex. Induction of pancreatitis leads to MAP kinase activation and transient suppression of the acinar differentiation programme. We investigated the role of MAP kinase-interacting kinase 1 (Mnk1) in mouse exocrine pancreas development and in the response to secretagogue-induced pancreatitis.
3386. Abnormal fibre usage in UC in remission.
作者: Sally L James.;Claus T Christophersen.;Anthony R Bird.;Michael A Conlon.;Ourania Rosella.;Peter R Gibson.;Jane G Muir.
来源: Gut. 2015年64卷4期562-70页
Colonic fermentation in patients with UC in remission was compared with that in matched healthy subjects on habitual diets and when dietary fibre was increased.
3387. Barrett's oesophagus patients with low-grade dysplasia can be accurately risk-stratified after histological review by an expert pathology panel.
作者: Lucas C Duits.;K Nadine Phoa.;Wouter L Curvers.;Fiebo J W Ten Kate.;Gerrit A Meijer.;Cees A Seldenrijk.;G Johan Offerhaus.;Mike Visser.;Sybren L Meijer.;Kausilia K Krishnadath.;Jan G P Tijssen.;Rosalie C Mallant-Hent.;Jacques J G H M Bergman.
来源: Gut. 2015年64卷5期700-6页
Reported malignant progression rates for low-grade dysplasia (LGD) in Barrett's oesophagus (BO) vary widely. Expert histological review of LGD is advised, but limited data are available on its clinical value. This retrospective cohort study aimed to determine the value of an expert pathology panel organised in the Dutch Barrett's Advisory Committee (BAC) by investigating the incidence rates of high-grade dysplasia (HGD) and oesophageal adenocarcinoma (OAC) after expert histological review of LGD.
3389. Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study.
作者: Frank Ulrich Weiss.;Claudia Schurmann.;Annett Guenther.;Florian Ernst.;Alexander Teumer.;Julia Mayerle.;Peter Simon.;Henry Völzke.;Dörte Radke.;Andreas Greinacher.;Jens-Peter Kuehn.;Martin Zenker.;Uwe Völker.;Georg Homuth.;Markus M Lerch.
来源: Gut. 2015年64卷4期646-56页
Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the reference range and in the absence of pancreatitis-are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis.
3390. Integration of tumour and viral genomic characterizations in HBV-related hepatocellular carcinomas.
作者: Giuliana Amaddeo.;Qian Cao.;Yannick Ladeiro.;Sandrine Imbeaud.;Jean-Charles Nault.;Daphne Jaoui.;Yann Gaston Mathe.;Christophe Laurent.;Alexis Laurent.;Paulette Bioulac-Sage.;Julien Calderaro.;Jessica Zucman-Rossi.
来源: Gut. 2015年64卷5期820-9页
Hepatocellular carcinoma (HCC) is the most common liver cancer. We characterised HCC associated with infection compared with non-HBV-related HCC to understand interactions between viral and hepatocyte genomic alterations and their relationships with clinical features.
3391. Diets that differ in their FODMAP content alter the colonic luminal microenvironment.
作者: Emma P Halmos.;Claus T Christophersen.;Anthony R Bird.;Susan J Shepherd.;Peter R Gibson.;Jane G Muir.
来源: Gut. 2015年64卷1期93-100页
A low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols) diet reduces symptoms of IBS, but reduction of potential prebiotic and fermentative effects might adversely affect the colonic microenvironment. The effects of a low FODMAP diet with a typical Australian diet on biomarkers of colonic health were compared in a single-blinded, randomised, cross-over trial.
3392. Mechanisms of activation of mouse and human enteroendocrine cells by nutrients.
作者: Erin L Symonds.;Madusha Peiris.;Amanda J Page.;Bridgette Chia.;Harween Dogra.;Abigail Masding.;Vasileios Galanakis.;Michael Atiba.;David Bulmer.;Richard L Young.;L Ashley Blackshaw.
来源: Gut. 2015年64卷4期618-26页
Inhibition of food intake and glucose homeostasis are both promoted when nutrients stimulate enteroendocrine cells (EEC) to release gut hormones. Several specific nutrient receptors may be located on EEC that respond to dietary sugars, amino acids and fatty acids. Bypass surgery for obesity and type II diabetes works by shunting nutrients to the distal gut, where it increases activation of nutrient receptors and mediator release, but cellular mechanisms of activation are largely unknown. We determined which nutrient receptors are expressed in which gut regions and in which cells in mouse and human, how they are associated with different types of EEC, how they are activated leading to hormone and 5-HT release.
3393. Targeting tumour necrosis factor receptor 1 assembly reverses Th17-mediated colitis through boosting a Th2 response.
作者: Shin-Huei Fu.;Ming-Hong Lin.;Li-Tzu Yeh.;Yen-Ling Wang.;Ming-Wei Chien.;Shih-Hua Lin.;Deh-Ming Chang.;Huey-Kang Sytwu.
来源: Gut. 2015年64卷5期765-75页
The soluble preligand assembly domain (PLAD) of tumour necrosis factor receptor 1 (TNFR1) interferes with receptor trimerisation to block downstream signalling, and mediates Th17 suppression. We explored the therapeutic potential of recombinant PLAD.Fc protein on a spontaneous experimental colitis.
3394. Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease.
作者: Stephanie Arndt.;Eva Wacker.;Christoph Dorn.;Andreas Koch.;Michael Saugspier.;Wolfgang E Thasler.;Arndt Hartmann.;Anja Katrin Bosserhoff.;Claus Hellerbrand.
来源: Gut. 2015年64卷6期973-81页
Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis. However, its further role in liver pathology including non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH) is elusive. The aim of this study was to investigate the expression and function of BMP6 in chronic liver disease.
3395. Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians.
作者: Pauline Arends.;Milan J Sonneveld.;Roeland Zoutendijk.;Ivana Carey.;Ashley Brown.;Massimo Fasano.;David Mutimer.;Katja Deterding.;Jurriën G P Reijnders.;Ye Oo.;Jörg Petersen.;Florian van Bömmel.;Robert J de Knegt.;Teresa Santantonio.;Thomas Berg.;Tania M Welzel.;Heiner Wedemeyer.;Maria Buti.;Pierre Pradat.;Fabien Zoulim.;Bettina Hansen.;Harry L A Janssen.; .
来源: Gut. 2015年64卷8期1289-95页
Hepatocellular carcinoma (HCC) risk-scores may predict HCC in Asian entecavir (ETV)-treated patients. We aimed to study risk factors and performance of risk scores during ETV treatment in an ethnically diverse Western population.
3396. FCGR polymorphisms and cetuximab efficacy in chemorefractory metastatic colorectal cancer: an international consortium study.
作者: Ravit Geva.;Loredana Vecchione.;Konstantinos T Kalogeras.;Benny Vittrup Jensen.;Heinz-Josef Lenz.;Takayuki Yoshino.;David Paez.;Clara Montagut.;John Souglakos.;Federico Cappuzzo.;Andrés Cervantes.;Milo Frattini.;George Fountzilas.;Julia S Johansen.;Estrid Vilma Høgdall.;Wu Zhang.;Dongyun Yang.;Kentaro Yamazaki.;Tomohiro Nishina.;Demetris Papamichael.;Bruno Vincenzi.;Teresa Macarulla.;Fotios Loupakis.;Jef De Schutter.;Karen Lise Garm Spindler.;Per Pfeiffer.;Fortunato Ciardiello.;Hubert Piessevaux.;Sabine Tejpar.
来源: Gut. 2015年64卷6期921-8页
We aimed to better clarify the role of germline variants of the FCG2 receptor, FCGR2A-H131R and FCGR3A-V158F, on the therapeutic efficacy of cetuximab in metastatic colorectal cancer (mCRC). A large cohort with sufficient statistical power was assembled.
3397. Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays.
作者: Kelli L VanDussen.;Jeffrey M Marinshaw.;Nurmohammad Shaikh.;Hiroyuki Miyoshi.;Clara Moon.;Phillip I Tarr.;Matthew A Ciorba.;Thaddeus S Stappenbeck.
来源: Gut. 2015年64卷6期911-20页
The technology for the growth of human intestinal epithelial cells is rapidly progressing. An exciting possibility is that this system could serve as a platform for individualised medicine and research. However, to achieve this goal, human epithelial culture must be enhanced so that biopsies from individuals can be used to reproducibly generate cell lines in a short time frame so that multiple, functional assays can be performed (ie, barrier function and host-microbial interactions).
3398. Liver injury in acute hepatitis A is associated with decreased frequency of regulatory T cells caused by Fas-mediated apoptosis.
作者: Yoon Seok Choi.;Jeewon Lee.;Hyun Woong Lee.;Dong-Yeop Chang.;Pil Soo Sung.;Min Kyung Jung.;Jun Yong Park.;Ja Kyung Kim.;Jung Il Lee.;Hana Park.;Jae Youn Cheong.;Kyung-Suk Suh.;Hyung Joon Kim.;June Sung Lee.;Kyung-Ah Kim.;Eui-Cheol Shin.
来源: Gut. 2015年64卷8期1303-13页
Foxp3(+)CD4(+)CD25(+) regulatory T cells (Tregs) control immune responses, but their role in acute viral hepatitis remains elusive. Herein, we investigated alteration in the peripheral blood Treg population during acute hepatitis A (AHA) and its implication in the immune-mediated liver injury.
3399. Progressive genomic convergence of two Helicobacter pylori strains during mixed infection of a patient with chronic gastritis.
作者: Qizhi Cao.;Xavier Didelot.;Zhongbiao Wu.;Zongwei Li.;Lihua He.;Yunsheng Li.;Ming Ni.;Yuanhai You.;Xi Lin.;Zhen Li.;Yanan Gong.;Minqiao Zheng.;Minli Zhang.;Jie Liu.;Weijun Wang.;Xiaochen Bo.;Daniel Falush.;Shengqi Wang.;Jianzhong Zhang.
来源: Gut. 2015年64卷4期554-61页
To study the detailed nature of genomic microevolution during mixed infection with multiple Helicobacter pylori strains in an individual.
3400. Serological and clinical outcomes of horizontally transmitted chronic hepatitis B infection in New Zealand Māori: results from a 28-year follow-up study.
作者: Tien Huey Lim.;Edward Gane.;Chris Moyes.;Barry Borman.;Chris Cunningham.
来源: Gut. 2015年64卷6期966-72页
Chronic hepatitis B infection is endemic in New Zealand and has high prevalence in New Zealand Māori. Previous longitudinal studies in populations with predominantly vertically acquired chronic hepatitis B have shown low spontaneous hepatitis B surface-antigen (HBsAg) seroclearance rates: 0.5-1.4% annually (mean age of clearance 48 years). We report the 28-year follow-up data on clinical and serological outcomes in indigenous New Zealand Māori with early horizontally acquired HBV.
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