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3361. A genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration.
作者: Lindsay Y King.;Claudia Canasto-Chibuque.;Kara B Johnson.;Shun Yip.;Xintong Chen.;Kensuke Kojima.;Manjeet Deshmukh.;Anu Venkatesh.;Poh Seng Tan.;Xiaochen Sun.;Augusto Villanueva.;Angelo Sangiovanni.;Venugopalan Nair.;Milind Mahajan.;Masahiro Kobayashi.;Hiromitsu Kumada.;Massimo Iavarone.;Massimo Colombo.;Maria Isabel Fiel.;Scott L Friedman.;Josep M Llovet.;Raymond T Chung.;Yujin Hoshida.
来源: Gut. 2015年64卷8期1296-302页
The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genomic and clinical variables to identify patients at high risk of disease progression.
3362. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants.
作者: Tanja Jaeggi.;Guus A M Kortman.;Diego Moretti.;Christophe Chassard.;Penny Holding.;Alexandra Dostal.;Jos Boekhorst.;Harro M Timmerman.;Dorine W Swinkels.;Harold Tjalsma.;Jane Njenga.;Alice Mwangi.;Jane Kvalsvig.;Christophe Lacroix.;Michael B Zimmermann.
来源: Gut. 2015年64卷5期731-42页
In-home iron fortification for infants in developing countries is recommended for control of anaemia, but low absorption typically results in >80% of the iron passing into the colon. Iron is essential for growth and virulence of many pathogenic enterobacteria. We determined the effect of high and low dose in-home iron fortification on the infant gut microbiome and intestinal inflammation.
3363. Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently.
作者: Anja Beilfuss.;Jan-Peter Sowa.;Svenja Sydor.;Mechthild Beste.;Lars P Bechmann.;Martin Schlattjan.;Wing-Kin Syn.;Inga Wedemeyer.;Zoltan Mathé.;Christoph Jochum.;Guido Gerken.;Robert K Gieseler.;Ali Canbay.
来源: Gut. 2015年64卷5期791-9页
Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity and constitutes part of the metabolic syndrome, which have been associated with low serum vitamin D (VD). Due to known crosstalk between VD and transforming growth factor (TGF)-β signalling, VD has been proposed as an antifibrotic treatment.
3364. A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis.
作者: Yuan Zhuang.;Ping Cheng.;Xiao-fei Liu.;Liu-sheng Peng.;Bo-sheng Li.;Ting-ting Wang.;Na Chen.;Wen-hua Li.;Yun Shi.;Weisan Chen.;Ken C Pang.;Ming Zeng.;Xu-hu Mao.;Shi-ming Yang.;Hong Guo.;Gang Guo.;Tao Liu.;Qian-fei Zuo.;Hui-jie Yang.;Liu-yang Yang.;Fang-yuan Mao.;Yi-pin Lv.;Quan-ming Zou.
来源: Gut. 2015年64卷9期1368-78页
Helper T (Th) cell responses are critical for the pathogenesis of Helicobacter pylori-induced gastritis. Th22 cells represent a newly discovered Th cell subset, but their relevance to H. pylori-induced gastritis is unknown.
3365. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells.
作者: Lydia E Wroblewski.;M Blanca Piazuelo.;Rupesh Chaturvedi.;Michael Schumacher.;Eitaro Aihara.;Rui Feng.;Jennifer M Noto.;Alberto Delgado.;Dawn A Israel.;Yana Zavros.;Marshall H Montrose.;Noah Shroyer.;Pelayo Correa.;Keith T Wilson.;Richard M Peek.
来源: Gut. 2015年64卷5期720-30页
Helicobacter pylori strains that express the oncoprotein CagA augment risk for gastric cancer. However, the precise mechanisms through which cag(+) strains heighten cancer risk have not been fully delineated and model systems that recapitulate the gastric niche are critical for understanding pathogenesis. Gastroids are three-dimensional organ-like structures that provide unique opportunities to study host-H. pylori interactions in a preclinical model. We used gastroids to inform and direct in vitro studies to define mechanisms through which H. pylori modulates expression of the cancer-associated tight junction protein claudin-7.
3366. Neurotensin--regulated miR-133α is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis.
作者: Ivy Ka Man Law.;Kyriaki Bakirtzi.;Christos Polytarchou.;Angelos Oikonomopoulos.;Daniel Hommes.;Dimitrios Iliopoulos.;Charalabos Pothoulakis.
来源: Gut. 2015年64卷7期1095-104页
Neurotensin (NT) mediates colonic inflammation through its receptor neurotensin receptor 1 (NTR1). NT stimulates miR-133α expression in colonic epithelial cells. We investigated the role of miR-133α in NT-associated colonic inflammation in vitro and in vivo.
3367. Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis.
作者: Mohammed Soutto.;DunFa Peng.;Ahmed Katsha.;Zheng Chen.;Maria Blanca Piazuelo.;Mary Kay Washington.;Abbes Belkhiri.;Pelayo Correa.;Wael El-Rifai.
来源: Gut. 2015年64卷7期1028-39页
In this study, we investigated the role of Trefoil factor 1 (TFF1) in regulating cell proliferation and tumour development through β-catenin signalling using in vivo and in vitro models of gastric tumorigenesis.
3371. Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study.
作者: Christophe Hézode.;Gideon M Hirschfield.;Wayne Ghesquiere.;William Sievert.;Maribel Rodriguez-Torres.;Stephen D Shafran.;Paul J Thuluvath.;Harvey A Tatum.;Imam Waked.;Gamal Esmat.;Eric J Lawitz.;Vinod K Rustgi.;Stanislas Pol.;Nina Weis.;Paul J Pockros.;Marc Bourlière.;Lawrence Serfaty.;John M Vierling.;Michael W Fried.;Ola Weiland.;Maurizia R Brunetto.;Gregory T Everson.;Stefan Zeuzem.;Paul Y Kwo.;Mark Sulkowski.;Norbert Bräu.;Dennis Hernandez.;Fiona McPhee.;Megan Wind-Rotolo.;Zhaohui Liu.;Stephanie Noviello.;Eric A Hughes.;Philip D Yin.;Steven Schnittman.
来源: Gut. 2015年64卷6期948-56页
To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin.
3373. Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis.
作者: Shaoping Wu.;Yong-Guo Zhang.;Rong Lu.;Yinglin Xia.;David Zhou.;Elaine O Petrof.;Erika C Claud.;Di Chen.;Eugene B Chang.;Geert Carmeliet.;Jun Sun.
来源: Gut. 2015年64卷7期1082-94页
Vitamin D and the vitamin D receptor (VDR) appear to be important immunological regulators of inflammatory bowel diseases (IBD). Defective autophagy has also been implicated in IBD, where interestingly, polymorphisms of genes such as ATG16L1 have been associated with increased risk. Although vitamin D, the microbiome and autophagy are all involved in pathogenesis of IBD, it remains unclear whether these processes are related or function independently.
3374. Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner.
作者: Jinxiong Wei.;Jennifer M Noto.;Elena Zaika.;Judith Romero-Gallo.;Maria Blanca Piazuelo.;Barbara Schneider.;Wael El-Rifai.;Pelayo Correa.;Richard M Peek.;Alexander I Zaika.
来源: Gut. 2015年64卷7期1040-8页
Infection with Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the stomach. Tumorigenic transformation of gastric epithelium induced by H. pylori is a highly complex process driven by an active interplay between bacterial virulence and host factors, many aspects of which remain obscure. In this work, we investigated the degradation of p53 tumour suppressor induced by H. pylori.
3375. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice.
作者: Fernando F Anhê.;Denis Roy.;Geneviève Pilon.;Stéphanie Dudonné.;Sébastien Matamoros.;Thibault V Varin.;Carole Garofalo.;Quentin Moine.;Yves Desjardins.;Emile Levy.;André Marette.
来源: Gut. 2015年64卷6期872-83页
The increasing prevalence of obesity and type 2 diabetes (T2D) demonstrates the failure of conventional treatments to curb these diseases. The gut microbiota has been put forward as a key player in the pathophysiology of diet-induced T2D. Importantly, cranberry (Vaccinium macrocarpon Aiton) is associated with a number of beneficial health effects. We aimed to investigate the metabolic impact of a cranberry extract (CE) on high fat/high sucrose (HFHS)-fed mice and to determine whether its consequent antidiabetic effects are related to modulations in the gut microbiota.
3376. Species-specific and pathotype-specific binding of bacteria to zymogen granule membrane glycoprotein 2 (GP2).
作者: Peter Schierack.;Stefan Rödiger.;Rafal Kolenda.;Rico Hiemann.;Enrico Berger.;Krzysztof Grzymajło.;Alexander Swidsinski.;Thomas Juretzek.;Dirk Meissner.;Karsten Mydlak.;Dirk Reinhold.;Lisa K Nolan.;Dirk Roggenbuck.
来源: Gut. 2015年64卷3期517-9页 3377. Human hepatic stellate cells are not permissive for hepatitis C virus entry and replication.
作者: Alexandre Florimond.;Philippe Chouteau.;Patrice Bruscella.;Jacques Le Seyec.;Emilie Mérour.;Nazim Ahnou.;Ariane Mallat.;Sophie Lotersztajn.;Jean-Michel Pawlotsky.
来源: Gut. 2015年64卷6期957-65页
Chronic HCV infection is associated with the development of hepatic fibrosis. The direct role of HCV in the fibrogenic process is unknown. Specifically, whether HCV is able to infect hepatic stellate cells (HSCs) is debated.
3378. Human buccal epithelium acquires microbial hyporesponsiveness at birth, a role for secretory leukocyte protease inhibitor.
作者: Celia L Menckeberg.;Jeroen Hol.;Ytje Simons-Oosterhuis.;H Rolien C Raatgeep.;Lilian F de Ruiter.;Dicky J Lindenbergh-Kortleve.;Anita M Korteland-van Male.;Sahar El Aidy.;Pieter P E van Lierop.;Michiel Kleerebezem.;Michael Groeneweg.;Georg Kraal.;Beatrix E Elink-Schuurman.;Johan C de Jongste.;Edward E S Nieuwenhuis.;Janneke N Samsom.
来源: Gut. 2015年64卷6期884-93页
Repetitive interaction with microbial stimuli renders epithelial cells (ECs) hyporesponsive to microbial stimulation. Previously, we have reported that buccal ECs from a subset of paediatric patients with Crohn's disease are not hyporesponsive and spontaneously released chemokines. We now aimed to identify kinetics and mechanisms of acquisition of hyporesponsiveness to microbial stimulation using primary human buccal epithelium.
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