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3321. Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.
作者: Yoshinaga Okugawa.;Yuji Toiyama.;Shusuke Toden.;Hiroki Mitoma.;Takeshi Nagasaka.;Koji Tanaka.;Yasuhiro Inoue.;Masato Kusunoki.;C Richard Boland.;Ajay Goel.
来源: Gut. 2017年66卷1期107-117页
Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clinical outcome of CRC patients. Recent evidence revealed the new role of small nucleolar RNAs (snoRNAs) in oncogenesis. Herein, we systematically evaluated dysregulation of snoRNAs in CRC and clarified their biomarker potential and biological significance in CRC.
3322. Development and validation of the Nancy histological index for UC.
作者: Aude Marchal-Bressenot.;Julia Salleron.;Camille Boulagnon-Rombi.;Claire Bastien.;Virginie Cahn.;Guillaume Cadiot.;Marie-Danièle Diebold.;Silvio Danese.;Walter Reinisch.;Stefan Schreiber.;Simon Travis.;Laurent Peyrin-Biroulet.
来源: Gut. 2017年66卷1期43-49页
We developed a validated index for assessing histological disease activity in UC and established its responsiveness.
3324. Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma.
作者: Xiaoguang Li.;Wenbo Yao.;Ya Yuan.;Peizhan Chen.;Bin Li.;Jingquan Li.;Ruiai Chu.;Haiyun Song.;Dong Xie.;Xiaoqing Jiang.;Hui Wang.
来源: Gut. 2017年66卷1期157-167页
Hepatocellular carcinoma (HCC) is an aggressive malignancy with limited effective treatment options. An alternative strategy is to target cells, such as tumour-infiltrating macrophages, in the HCC tumour microenvironment. The CCL2/CCR2 axis is required for recruitment of monocytes/macrophages and is implicated in various aspects of liver pathology, including HCC. We investigated the feasibility of CCL2/CCR2 as a therapeutic target against HCC.
3325. Specific members of the predominant gut microbiota predict pouchitis following colectomy and IPAA in UC.
作者: Kathleen Machiels.;João Sabino.;Leen Vandermosten.;Marie Joossens.;Ingrid Arijs.;Magali de Bruyn.;Venessa Eeckhaut.;Gert Van Assche.;Marc Ferrante.;Jan Verhaegen.;Kristel Van Steen.;Filip Van Immerseel.;Geert Huys.;Kristin Verbeke.;Albert Wolthuis.;Anthony de Buck Van Overstraeten.;Andre D'Hoore.;Paul Rutgeerts.;Séverine Vermeire.
来源: Gut. 2017年66卷1期79-88页
Pouchitis is the most common complication after colectomy with ileal pouch-anal anastomosis (IPAA) for UC and the risk is the highest within the 1st year after surgery. The pathogenesis is not completely understood but clinical response to antibiotics suggests a role for gut microbiota. We hypothesised that the risk for pouchitis can be predicted based on the faecal microbial composition before colectomy.
3326. Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen.
作者: Tian-Ying Zhang.;Quan Yuan.;Jing-Hua Zhao.;Ya-Li Zhang.;Lun-Zhi Yuan.;Ying Lan.;Yu-Chieh Lo.;Cheng-Pu Sun.;Chang-Ru Wu.;Jun-Fang Zhang.;Ying Zhang.;Jia-Li Cao.;Xue-Ran Guo.;Xuan Liu.;Xiao-Bing Mo.;Wen-Xin Luo.;Tong Cheng.;Yi-Xin Chen.;Mi-Hua Tao.;James Wk Shih.;Qin-Jian Zhao.;Jun Zhang.;Pei-Jer Chen.;Y Adam Yuan.;Ning-Shao Xia.
来源: Gut. 2016年65卷4期658-71页
This study aimed to investigate the therapeutic potential of monoclonal antibody (mAb) against HBV as a novel treatment approach to chronic hepatitis B (CHB) in mouse models.
3328. TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro.
作者: Maria Reich.;Kathleen Deutschmann.;Annika Sommerfeld.;Caroline Klindt.;Stefanie Kluge.;Ralf Kubitz.;Christoph Ullmer.;Wolfram T Knoefel.;Diran Herebian.;Ertan Mayatepek.;Dieter Häussinger.;Verena Keitel.
来源: Gut. 2016年65卷3期487-501页
Cholestatic liver diseases in humans as well as bile acid (BA)-feeding and common bile duct ligation (CBDL) in rodents trigger hyperplasia of cholangiocytes within the portal fields. Furthermore, elevation of BA levels enhances proliferation and invasiveness of cholangiocarcinoma (CCA) cells in animal models, thus promoting tumour progression. TGR5 is a G-protein coupled BA receptor, which is highly expressed in cholangiocytes and postulated to mediate the proliferative effects of BA.
3330. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome.
作者: Francesca De Filippis.;Nicoletta Pellegrini.;Lucia Vannini.;Ian B Jeffery.;Antonietta La Storia.;Luca Laghi.;Diana I Serrazanetti.;Raffaella Di Cagno.;Ilario Ferrocino.;Camilla Lazzi.;Silvia Turroni.;Luca Cocolin.;Patrizia Brigidi.;Erasmo Neviani.;Marco Gobbetti.;Paul W O'Toole.;Danilo Ercolini.
来源: Gut. 2016年65卷11期1812-1821页
Habitual diet plays a major role in shaping the composition of the gut microbiota, and also determines the repertoire of microbial metabolites that can influence the host. The typical Western diet corresponds to that of an omnivore; however, the Mediterranean diet (MD), common in the Western Mediterranean culture, is to date a nutritionally recommended dietary pattern that includes high-level consumption of cereals, fruit, vegetables and legumes. To investigate the potential benefits of the MD in this cross-sectional survey, we assessed the gut microbiota and metabolome in a cohort of Italian individuals in relation to their habitual diets.
3331. Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer.
作者: Jun Yu.;Qiang Feng.;Sunny Hei Wong.;Dongya Zhang.;Qiao Yi Liang.;Youwen Qin.;Longqing Tang.;Hui Zhao.;Jan Stenvang.;Yanli Li.;Xiaokai Wang.;Xiaoqiang Xu.;Ning Chen.;William Ka Kei Wu.;Jumana Al-Aama.;Hans Jørgen Nielsen.;Pia Kiilerich.;Benjamin Anderschou Holbech Jensen.;Tung On Yau.;Zhou Lan.;Huijue Jia.;Junhua Li.;Liang Xiao.;Thomas Yuen Tung Lam.;Siew Chien Ng.;Alfred Sze-Lok Cheng.;Vincent Wai-Sun Wong.;Francis Ka Leung Chan.;Xun Xu.;Huanming Yang.;Lise Madsen.;Christian Datz.;Herbert Tilg.;Jian Wang.;Nils Brünner.;Karsten Kristiansen.;Manimozhiyan Arumugam.;Joseph Jao-Yiu Sung.;Jun Wang.
来源: Gut. 2017年66卷1期70-78页
To evaluate the potential for diagnosing colorectal cancer (CRC) from faecal metagenomes.
3332. Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.
作者: Sabine Klein.;Johanna Rick.;Jennifer Lehmann.;Robert Schierwagen.;Irela Gretchen Schierwagen.;Len Verbeke.;Kanishka Hittatiya.;Frank Erhard Uschner.;Steffen Manekeller.;Christian P Strassburg.;Kay-Uwe Wagner.;Peter P Sayeski.;Dominik Wolf.;Wim Laleman.;Tilman Sauerbruch.;Jonel Trebicka.
来源: Gut. 2017年66卷1期145-155页
Angiotensin II (AngII) activates via angiotensin-II-type-I receptor (AT1R) Janus-kinase-2 (JAK2)/Arhgef1 pathway and subsequently RHOA/Rho-kinase (ROCK), which induces experimental and probably human liver fibrosis. This study investigated the relationship of JAK2 to experimental and human portal hypertension.
3333. Attendance and diagnostic yield of repeated two-sample faecal immunochemical test screening for colorectal cancer.
作者: Atija Kapidzic.;Aafke H C van Roon.;Monique E van Leerdam.;Anneke J van Vuuren.;Marjolein van Ballegooijen.;Iris Lansdorp-Vogelaar.;Wolfert Spijker.;Kirsten Izelaar.;Lieke Hol.;Ernst J Kuipers.
来源: Gut. 2017年66卷1期118-123页
Limited data exist on attendance and additional yield of 2-sample faecal immunochemical testing (FIT) screening during multiple rounds. We therefore conducted a population-based colorectal cancer screening trial comparing attendance and yield of repeated 1-sample and 2-sample FIT screenings.
3334. hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation.
作者: Changjiang Hu.;Zhenghong Ni.;Bo-Sheng Li.;Xin Yong.;Xin Yang.;Jian-Wei Zhang.;Dan Zhang.;Yong Qin.;Meng-Meng Jie.;Hui Dong.;Song Li.;Fengtian He.;Shi-Ming Yang.
来源: Gut. 2017年66卷1期31-42页
Human telomerase reverse transcriptase (hTERT) plays an important role in cancer invasion, but the relevant mechanism is not well known. This study aims to investigate the role and mechanism of hTERT in gastric cancer metastasis.
3335. IOIBD technical review on endoscopic indices for Crohn's disease clinical trials.
作者: L Vuitton.;P Marteau.;W J Sandborn.;B G Levesque.;B Feagan.;S Vermeire.;S Danese.;G D'Haens.;M Lowenberg.;R Khanna.;G Fiorino.;S Travis.;J Y Mary.;L Peyrin-Biroulet.
来源: Gut. 2016年65卷9期1447-55页
Crohn's disease (CD) is a chronic disabling and progressive IBD. Only strategies looking beyond symptoms and based on tight monitoring of objective signs of inflammation such as mucosal lesions may have the potential for disease modification. Endoscopic evaluation is currently the gold standard to assess mucosal lesions and has become a major therapeutic endpoint in clinical trials. Several endoscopic indices have been proposed to evaluate disease activity; unvalidated and arbitrary definitions have been used in clinical trials for defining endoscopic response and endoscopic remission in CD.
3336. MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.
作者: Eva M Serrao.;Mikko I Kettunen.;Tiago B Rodrigues.;Piotr Dzien.;Alan J Wright.;Aarthi Gopinathan.;Ferdia A Gallagher.;David Y Lewis.;Kristopher K Frese.;Jaime Almeida.;William J Howat.;David A Tuveson.;Kevin M Brindle.
来源: Gut. 2016年65卷3期465-75页
Pancreatic cancer (PCa) is treatable by surgery when detected at an early stage. Non-invasive imaging methods able to detect both established tumours and their precursor lesions are needed to select patients for surgery. We investigated here whether pancreatic preneoplasia could be detected prior to the development of invasive cancers in genetically engineered mouse models of PCa using metabolic imaging.
3337. Biomarkers for bile acid diarrhoea in functional bowel disorder with diarrhoea: a systematic review and meta-analysis.
作者: Nelson Valentin.;Michael Camilleri.;Osama Altayar.;Priya Vijayvargiya.;Andres Acosta.;Alfred D Nelson.;M Hassan Murad.
来源: Gut. 2016年65卷12期1951-1959页
There is no universally available laboratory test to diagnose bile acid diarrhoea (BAD).
3338. Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease.
作者: Paolo Biancheri.;Antonio Di Sabatino.;Maria Rescigno.;Paolo Giuffrida.;Giulia Fornasa.;Katerina Tsilingiri.;Sylvia L F Pender.;Cinzia Papadia.;Eleanor Wood.;Alessandra Pasini.;Cristina Ubezio.;Alessandro Vanoli.;Alastair Forbes.;Thomas T MacDonald.;Gino R Corazza.
来源: Gut. 2016年65卷10期1670-80页
The short isoform of thymic stromal lymphopoietin (TSLP), a cytokine constitutively expressed by epithelial cells, is crucial in preserving immune tolerance in the gut. TSLP deficiency has been implicated in sustaining intestinal damage in Crohn's disease. We explored mucosal TSLP expression and function in refractory and uncomplicated coeliac disease (CD), a T-cell-mediated enteropathy induced by gluten in genetically susceptible individuals.
3339. Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression.
作者: Xavier Loyer.;Valérie Paradis.;Carole Hénique.;Anne-Clémence Vion.;Nathalie Colnot.;Coralie L Guerin.;Cécile Devue.;Sissi On.;Jérémy Scetbun.;Mélissa Romain.;Jean-Louis Paul.;Marc E Rothenberg.;Patrick Marcellin.;François Durand.;Pierre Bedossa.;Carina Prip-Buus.;Eric Baugé.;Bart Staels.;Chantal M Boulanger.;Alain Tedgui.;Pierre-Emmanuel Rautou.
来源: Gut. 2016年65卷11期1882-1894页
Previous studies suggested that microRNA-21 may be upregulated in the liver in non-alcoholic steatohepatitis (NASH), but its role in the development of this disease remains unknown. This study aimed to determine the role of microRNA-21 in NASH.
3340. SETD2 histone modifier loss in aggressive GI stromal tumours.
作者: Kie Kyon Huang.;John R McPherson.;Su Ting Tay.;Kakoli Das.;Iain Beehuat Tan.;Cedric Chuan Young Ng.;Na-Yu Chia.;Shen Li Zhang.;Swe Swe Myint.;Longyu Hu.;Vikneswari Rajasegaran.;Dachuan Huang.;Jia Liang Loh.;Anna Gan.;Alisa Noor Hidayah Sairi.;Xin Xiu Sam.;Lourdes Trinidad Dominguez.;Minghui Lee.;Khee Chee Soo.;London Lucien Peng Jin Ooi.;Hock Soo Ong.;Alexander Chung.;Pierce Kah-Hoe Chow.;Wai Keong Wong.;Sathiyamoorthy Selvarajan.;Choon Kiat Ong.;Kiat Hon Lim.;Tannistha Nandi.;Steve Rozen.;Bin Tean Teh.;Richard Quek.;Patrick Tan.
来源: Gut. 2016年65卷12期1960-1972页
GI stromal tumours (GISTs) are clinically heterogenous exhibiting varying degrees of disease aggressiveness in individual patients.
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