当前位置: 首页 >> 检索结果
3202. Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues.
作者: Rong Fan.;Jian Sun.;Quan Yuan.;Qing Xie.;Xuefan Bai.;Qin Ning.;Jun Cheng.;Yanyan Yu.;Junqi Niu.;Guangfeng Shi.;Hao Wang.;Deming Tan.;Mobin Wan.;Shijun Chen.;Min Xu.;Xinyue Chen.;Hong Tang.;Jifang Sheng.;Fengmin Lu.;Jidong Jia.;Hui Zhuang.;Ningshao Xia.;Jinlin Hou.; .
来源: Gut. 2016年65卷2期313-20页
The investigation regarding the clinical significance of quantitative hepatitis B core antibody (anti-HBc) during chronic hepatitis B (CHB) treatment is limited. The aim of this study was to determine the performance of anti-HBc as a predictor for hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive CHB patients treated with peginterferon (Peg-IFN) or nucleos(t)ide analogues (NUCs), respectively.
3203. Adherence to surveillance guidelines after removal of colorectal adenomas: a large, community-based study.
作者: Else-Mariëtte B van Heijningen.;Iris Lansdorp-Vogelaar.;Ewout W Steyerberg.;S Lucas Goede.;Evelien Dekker.;Wilco Lesterhuis.;Frank ter Borg.;Juda Vecht.;Pieter Spoelstra.;Leopold Engels.;Clemens J M Bolwerk.;Robin Timmer.;Jan H Kleibeuker.;Jan J Koornstra.;Harry J de Koning.;Ernst J Kuipers.;Marjolein van Ballegooijen.
来源: Gut. 2015年64卷10期1584-92页
To determine adherence to recommended surveillance intervals in clinical practice.
3204. Preoperative endoscopic ultrasound-guided fine needle aspiration does not impair survival of patients with resected pancreatic cancer.
作者: Saowanee Ngamruengphong.;Kristi M Swanson.;Nilay D Shah.;Michael B Wallace.
来源: Gut. 2015年64卷7期1105-10页
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) allows preoperative tissue confirmation of malignancy, but fear of tumour cell dissemination along the needle track has limited its use. We hypothesised that if tumour cell dissemination occurs with EUS-FNA, survival after complete resection would be impaired. We aimed to evaluate the association of preoperative EUS-FNA with long-term outcomes of patients with resected pancreatic cancer.
3208. Geographical patterns of the standing and active human gut microbiome in health and IBD.
作者: Ateequr Rehman.;Philipp Rausch.;Jun Wang.;Jurgita Skieceviciene.;Gediminas Kiudelis.;Ketan Bhagalia.;Deepak Amarapurkar.;Limas Kupcinskas.;Stefan Schreiber.;Philip Rosenstiel.;John F Baines.;Stephan Ott.
来源: Gut. 2016年65卷2期238-48页
A global increase of IBD has been reported, especially in countries that previously had low incidence rates. Also, the knowledge of the human gut microbiome is steadily increasing, however, limited information regarding its variation on a global scale is available. In the light of the microbial involvement in IBDs, we aimed to (1) identify shared and distinct IBD-associated mucosal microbiota patterns from different geographical regions including Europe (Germany, Lithuania) and South Asia (India) and (2) determine whether profiling based on 16S rRNA transcripts provides additional resolution, both of which may hold important clinical relevance.
3209. Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study.
作者: Palak J Trivedi.;Willem J Lammers.;Henk R van Buuren.;Albert Parés.;Annarosa Floreani.;Harry L A Janssen.;Pietro Invernizzi.;Pier Maria Battezzati.;Cyriel Y Ponsioen.;Christophe Corpechot.;Raoul Poupon.;Marlyn J Mayo.;Andrew K Burroughs.;Frederik Nevens.;Andrew L Mason.;Kris V Kowdley.;Ana Lleo.;Llorenç Caballeria.;Keith D Lindor.;Bettina E Hansen.;Gideon M Hirschfield.; .
来源: Gut. 2016年65卷2期321-9页
Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate risk factors for HCC development in patients with PBC.
3211. Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study.
作者: Walter Reinisch.;Julián Panés.;Sunil Khurana.;Gabor Toth.;Fei Hua.;Gail M Comer.;Michelle Hinz.;Karen Page.;Margot O'Toole.;Tara McDonnell Moorehead.;Hua Zhu.;YanHui Sun.;Fabio Cataldi.
来源: Gut. 2015年64卷6期894-900页
Interleukin 13 (IL-13) is thought to play a key role as an effector cytokine in UC. Anrukinzumab, a humanised antibody that inhibits human IL-13, was evaluated for the treatment of UC.
3215. A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro.
作者: Philipp Schlaermann.;Benjamin Toelle.;Hilmar Berger.;Sven C Schmidt.;Matthias Glanemann.;Jürgen Ordemann.;Sina Bartfeld.;Hans J Mollenkopf.;Thomas F Meyer.
来源: Gut. 2016年65卷2期202-13页
Helicobacter pylori is the causative agent of gastric diseases and the main risk factor in the development of gastric adenocarcinoma. In vitro studies with this bacterial pathogen largely rely on the use of transformed cell lines as infection model. However, this approach is intrinsically artificial and especially inappropriate when it comes to investigating the mechanisms of cancerogenesis. Moreover, common cell lines are often defective in crucial signalling pathways relevant to infection and cancer. A long-lived primary cell system would be preferable in order to better approximate the human in vivo situation.
3217. Motilin-induced gastric contractions signal hunger in man.
作者: J Tack.;E Deloose.;D Ang.;E Scarpellini.;T Vanuytsel.;L Van Oudenhove.;I Depoortere.
来源: Gut. 2016年65卷2期214-24页
Hunger is controlled by the brain, which receives input from signals of the GI tract (GIT). During fasting, GIT displays a cyclical motor pattern, the migrating motor complex (MMC), regulated by motilin.
3218. Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry.
作者: R J Haidry.;M A Butt.;J M Dunn.;A Gupta.;G Lipman.;H L Smart.;P Bhandari.;L Smith.;R Willert.;G Fullarton.;M Di Pietro.;C Gordon.;I Penman.;H Barr.;P Patel.;N Kapoor.;J Hoare.;R Narayanasamy.;Y Ang.;A Veitch.;K Ragunath.;M Novelli.;L B Lovat.; .
来源: Gut. 2015年64卷8期1192-9页
Barrett's oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA) is an alternative to surgery for patients with BE-related neoplasia.
3220. Randomised controlled trial of mesalazine in IBS.
作者: Giovanni Barbara.;Cesare Cremon.;Vito Annese.;Guido Basilisco.;Franco Bazzoli.;Massimo Bellini.;Antonio Benedetti.;Luigi Benini.;Fabrizio Bossa.;Paola Buldrini.;Michele Cicala.;Rosario Cuomo.;Bastianello Germanà.;Paola Molteni.;Matteo Neri.;Marcello Rodi.;Alfredo Saggioro.;Maria Lia Scribano.;Maurizio Vecchi.;Giorgio Zoli.;Roberto Corinaldesi.;Vincenzo Stanghellini.
来源: Gut. 2016年65卷1期82-90页
Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS.
|