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3182. The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon.
作者: Wesley A Grimm.;Jeannette S Messer.;Stephen F Murphy.;Thomas Nero.;James P Lodolce.;Christopher R Weber.;Mark F Logsdon.;Sarah Bartulis.;Brooke E Sylvester.;Amanda Springer.;Urszula Dougherty.;Timothy B Niewold.;Sonia S Kupfer.;Nathan Ellis.;Dezheng Huo.;Marc Bissonnette.;David L Boone.
来源: Gut. 2016年65卷3期456-64页
ATG16L1 is an autophagy gene known to control host immune responses to viruses and bacteria. Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously identified as a risk factor in Crohn's disease (CD), was associated with more favourable clinical outcomes in thyroid cancer. Mechanisms underlying this observation have not been proposed, nor is it clear whether an association between Thr300Ala and clinical outcomes will be observed in other cancers. We hypothesised that Thr300Ala influences clinical outcome in human colorectal cancer (CRC) and controls innate antiviral pathways in colon cancer cells.
3183. Time to progression of pancreatic ductal adenocarcinoma from low-to-high tumour stages.
作者: Jun Yu.;Amanda L Blackford.;Marco Dal Molin.;Christopher L Wolfgang.;Michael Goggins.
来源: Gut. 2015年64卷11期1783-9页
Although pancreatic ductal adenocarcinoma is considered a rapidly progressive disease, mathematical models estimate that it takes many years for an initiating pancreatic cancer cell to grow into an advanced stage cancer. In order to estimate the time it takes for a pancreatic cancer to progress through different tumor, node, metastasis (TNM) stages, we compared the mean age of patients with pancreatic cancers of different sizes and stages.
3184. Training and competence assessment in GI endoscopy: a systematic review.
作者: Vivian E Ekkelenkamp.;Arjun D Koch.;Robert A de Man.;Ernst J Kuipers.
来源: Gut. 2016年65卷4期607-15页
Training procedural skills in GI endoscopy once focused on threshold numbers. As threshold numbers poorly reflect individual competence, the focus gradually shifts towards a more individual approach. Tools to assess and document individual learning progress are being developed and incorporated in dedicated training curricula. However, there is a lack of consensus and training guidelines differ worldwide, which reflects uncertainties on optimal set-up of a training programme.
3185. Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites.
作者: Paolo Angeli.;Pere Gines.;Florence Wong.;Mauro Bernardi.;Thomas D Boyer.;Alexander Gerbes.;Richard Moreau.;Rajiv Jalan.;Shiv K Sarin.;Salvatore Piano.;Kevin Moore.;Samuel S Lee.;Francois Durand.;Francesco Salerno.;Paolo Caraceni.;W Ray Kim.;Vicente Arroyo.;Guadalupe Garcia-Tsao.; .
来源: Gut. 2015年64卷4期531-7页 3187. Colonisation with multidrug-resistant bacteria is associated with increased mortality in patients with cirrhosis.
作者: Oliver Waidmann.;Volkhard A Kempf.;Christian Brandt.;Stefan Zeuzem.;Albrecht Piiper.;Bernd Kronenberger.
来源: Gut. 2015年64卷7期1183-4页 3188. Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks.
作者: Andrey Morgun.;Amiran Dzutsev.;Xiaoxi Dong.;Renee L Greer.;D Joseph Sexton.;Jacques Ravel.;Martin Schuster.;William Hsiao.;Polly Matzinger.;Natalia Shulzhenko.
来源: Gut. 2015年64卷11期1732-43页
Despite widespread use of antibiotics for the treatment of life-threatening infections and for research on the role of commensal microbiota, our understanding of their effects on the host is still very limited.
3189. Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress.
作者: Hassan Melhem.;Franck Hansmannel.;Aude Bressenot.;Syue-Fang Battaglia-Hsu.;Vincent Billioud.;Jean Marc Alberto.;Jean Louis Gueant.;Laurent Peyrin-Biroulet.
来源: Gut. 2016年65卷4期595-606页
Methyl donor deficiency (MDD) aggravates experimental colitis in rats and increases endoplasmic reticulum (ER) stress through decreased sirtuin 1 (SIRT1) in neuronal cells and myocardium. ER stress plays a key role in IBD pathogenesis.
3190. Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages.
作者: Wenjiang Yan.;Xiao Liu.;Hongxin Ma.;Hualin Zhang.;Xiaojia Song.;Lifen Gao.;Xiaohong Liang.;Chunhong Ma.
来源: Gut. 2015年64卷10期1593-604页
Tumour-associated macrophages (TAMs) and their alternative activation contribute greatly to the development of hepatocellular carcinoma (HCC). Tim-3 is highly expressed on macrophages and regulates macrophage functions in several conditions. However, whether Tim-3 is involved in the activation and the function of TAMs has not been reported.
3191. A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.
作者: Bo Kong.;Weiwei Wu.;Tao Cheng.;Anna Melissa Schlitter.;Chengjia Qian.;Philipp Bruns.;Ziying Jian.;Carsten Jäger.;Ivonne Regel.;Susanne Raulefs.;Nora Behler.;Martin Irmler.;Johannes Beckers.;Helmut Friess.;Mert Erkan.;Jens T Siveke.;Andrea Tannapfel.;Stephan A Hahn.;Fabian J Theis.;Irene Esposito.;Jörg Kleeff.;Christoph W Michalski.
来源: Gut. 2016年65卷4期647-57页
Oncogenic Kras-activated robust Mek/Erk signals phosphorylate to the tuberous sclerosis complex (Tsc) and deactivates mammalian target of rapamycin (mTOR) suppression in pancreatic ductal adenocarcinoma (PDAC); however, Mek and mTOR inhibitors alone have demonstrated minimal clinical antitumor activity.
3193. Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers.
作者: A Lavelle.;G Lennon.;O O'Sullivan.;N Docherty.;A Balfe.;A Maguire.;H E Mulcahy.;G Doherty.;D O'Donoghue.;J Hyland.;R P Ross.;J C Coffey.;K Sheahan.;P D Cotter.;F Shanahan.;D C Winter.;P R O'Connell.
来源: Gut. 2015年64卷10期1553-61页
The relevance of spatial composition in the microbial changes associated with UC is unclear. We coupled luminal brush samples, mucosal biopsies and laser capture microdissection with deep sequencing of the gut microbiota to develop an integrated spatial assessment of the microbial community in controls and UC.
3194. Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.
作者: Gregory A Michelotti.;Anikia Tucker.;Marzena Swiderska-Syn.;Mariana Verdelho Machado.;Steve S Choi.;Leandi Kruger.;Erik Soderblom.;J Will Thompson.;Meredith Mayer-Salman.;Heather A Himburg.;Cynthia A Moylan.;Cynthia D Guy.;Katherine S Garman.;Richard T Premont.;John P Chute.;Anna Mae Diehl.
来源: Gut. 2016年65卷4期683-92页
The ductular reaction (DR) involves mobilisation of reactive-appearing duct-like cells (RDC) along canals of Hering, and myofibroblastic (MF) differentiation of hepatic stellate cells (HSC) in the space of Disse. Perivascular cells in stem cell niches produce pleiotrophin (PTN) to inactivate the PTN receptor, protein tyrosine phosphatase receptor zeta-1 (PTPRZ1), thereby augmenting phosphoprotein-dependent signalling. We hypothesised that the DR is regulated by PTN/PTPRZ1 signalling.
3196. Tenofovir monotherapy versus tenofovir and entecavir combination therapy in patients with entecavir-resistant chronic hepatitis B with multiple drug failure: results of a randomised trial.
作者: Young-Suk Lim.;Kwan Soo Byun.;Byung Chul Yoo.;So Young Kwon.;Yoon Jun Kim.;Jihyun An.;Han Chu Lee.;Yung Sang Lee.
来源: Gut. 2016年65卷5期852-60页
Little clinical data are available regarding the optimal treatment of patients who harbour entecavir (ETV)-resistant HBV.
3197. The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.
作者: Paola Martinelli.;Francesc Madriles.;Marta Cañamero.;Enrique Carrillo-de Santa Pau.;Natalia Del Pozo.;Carmen Guerra.;Francisco X Real.
来源: Gut. 2016年65卷3期476-86页
Gata6 is required to complete and maintain acinar differentiation in the mouse pancreas. Pancreas-specific Gata6 ablation during development causes extensive and persistent acinar-ductal metaplasia, which is considered an initial step of mutant KRas-driven carcinogenesis. Therefore, the Gata6-null pancreas might represent a tumour-prone environment. We investigated whether Gata6 plays a role during pancreatic tumorigenesis.
3198. Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
作者: Mingyang Song.;Reiko Nishihara.;Molin Wang.;Andrew T Chan.;Zhi Rong Qian.;Kentaro Inamura.;Xuehong Zhang.;Kimmie Ng.;Sun A Kim.;Kosuke Mima.;Yasutaka Sukawa.;Katsuhiko Nosho.;Charles S Fuchs.;Edward L Giovannucci.;Kana Wu.;Shuji Ogino.
来源: Gut. 2016年65卷2期296-304页
Evidence suggests protective effects of vitamin D and antitumour immunity on colorectal cancer risk. Immune cells in tumour microenvironment can convert 25-hydroxyvitamin D [25(OH)D] to bioactive 1α,25-dihydroxyvitamin D3, which influences neoplastic and immune cells as an autocrine and paracrine factor. Thus, we hypothesised that the inverse association between vitamin D and colorectal cancer risk might be stronger for cancers with high-level immune response than those with low-level immune response.
3199. Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria.
作者: Antony Cougnoux.;Julien Delmas.;Lucie Gibold.;Tiphanie Faïs.;Chiara Romagnoli.;Frederic Robin.;Gabriel Cuevas-Ramos.;Eric Oswald.;Arlette Darfeuille-Michaud.;Fabio Prati.;Guillaume Dalmasso.;Richard Bonnet.
来源: Gut. 2016年65卷2期278-85页
Colorectal cancers (CRCs) are frequently colonised by colibactin toxin-producing Escherichia coli bacteria that induce DNA damage in host cells and exhibit protumoural activities. Our objective was to identify small molecules inhibiting the toxic effects induced by these colibactin-producing bacteria.
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