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308. Newly Onset Dyspnea During Pregnancy.
作者: Marie Vermant.;Valerie Van Ballaer.;Tine Follet.;Eveline Claeys.;Samuel De Bontridder.;Nico De Crem.;Adriana Dubbeldam.;Alexandros Kalkanis.;Laurens J De Sadeleer.;Ellen De Langhe.;Wim A Wuyts.
来源: Chest. 2025年168卷4期e115-e120页 309. Respiratory Dyskinesia With Refractory Tachypnea and Alkalosis Treated by Vesicular Monoamine Transporter 2 Inhibitor.
We present the case of a 69-year-old woman with a 25-year history of psychosis, managed with risperidone, who developed refractory tachypnea and alkalosis over 2 weeks. Despite multidisciplinary evaluation, she was initially misdiagnosed with psychogenic hyperventilation. Ultimately, a diagnosis of respiratory dyskinesia (RD) was established, and substantial clinical improvement was achieved after initiation of a vesicular monoamine transporter 2 (VMAT2) inhibitor. The substantial effectiveness of this therapy was confirmed over a 7-month follow-up period, with monitoring of both clinical symptoms and arterial blood gas parameters. This case highlights the diagnostic challenges posed by RD and underscores the potential utility of VMAT2 inhibitor as a novel therapeutic option.
310. A 44-Year-Old Man With a Solitary, Slowly Enlarging Mediastinal Lesion.
作者: Vasiliki Kolokotroni.;Garyfallia Perlepe.;Angeliki Cheva.;Christoforos Foroulis.;Konstantinos I Gourgoulianis.
来源: Chest. 2025年168卷4期e107-e110页
A 44-year-old man, who does not smoke, presented for investigation of a right mediastinum lesion as revealed on a routine radiograph that was performed as a requirement of his life insurance. The patient reported no associated symptoms. He did not report shortness of breath, cough, sputum, fever, chest pain, or hemoptysis. The remaining review of symptoms was also negative for issues such as muscle weakness, weight loss, night sweats, fatigue, skin rash, and visible, palpable, or painful lymphadenopathy. His medical history was unremarkable, and he did not receive any regular medication. The patient's professional occupation was not related to special exposure and he did not report alcohol consumption, illicit drug use, or any recent travel.
320. Lung Cancer Risk in Preserved Ratio Impaired Spirometry and Airway Obstruction: A UK Biobank Study.
Preserved ratio impaired spirometry (PRISm) has emerged as a distinct pulmonary pattern with potential clinical significance, but its association with lung cancer risk remains unclear.
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