Structural variations (SVs) have significant effects on microbial phenotypes. The underlying mechanism of functional changes caused by gut microbial SVs in the development of ulcerative colitis (UC) need further investigation.

Cardiometabolic index (CMI) was proposed ten years ago as an indicator combining obesity and dyslipidemia. This study aimed to investigate the relationships between newly modified CMI (MCMI) with non-alcoholic fatty liver disease (NAFLD) and liver fibrosis.

The NAPOLI 3 trial demonstrated that compared to the nab-paclitaxel and gemcitabine (GemNab) regimen, the NALIRIFOX (5-fluorouracil, leucovorin, liposomal irinotecan, oxaliplatin) regimen can significantly improve patients' overall survival (OS) and progression-free survival (PFS), and the safety of this regimen is generally controllable. To ensure the appropriateness of the chosen treatment, economic evaluation is essential. Thus, from the perspective of American healthcare systems, we explored the cost-effectiveness comparison between NALIRIFOX or GemNab in treating patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) who had not previously received treatment.

Gallstones, a global hepatobiliary disorder, are linked to systemic inflammation, lipid disturbances, and metabolic-associated fatty liver disease (MAFLD). This population-based study aims to investigate the association of the novel inflammation-lipid composite biomarker high-sensitivity C-reactive protein-to-HDL cholesterol ratio (CHR) with gallstones and evaluate whether MAFLD mediates this relationship.

We aimed at developing a nomogram able to predict postoperative pulmonary complications (PPC) after gastrointestinal surgery.

The pace of artificial intelligence (AI) integration into health care has accelerated with rapid advances in generative AI (genAI). Gastroenterology and hepatology in particular will be transformed due to the multimodal workflows that integrate endoscopic video, radiologic imaging, tabular data, and unstructured note text. GenAI will impact the entire spectrum of clinical experience, from administrative tasks, diagnostic guidance, and treatment recommendations. Unlike traditional machine learning approaches, genAI is more flexible, with one platform able to be used across multiple tasks. Initial evidence suggests benefits in lower-level administrative tasks, such as clinical documentation, medical billing, and scheduling; and information tasks, such as patient education and summarization of the medical literature. No evidence exists for genAI solutions for more complex tasks relevant to clinical care, such as clinical reasoning for diagnostic and treatment decisions that may affect patient outcomes. Challenges of output reliability, data privacy, and useful integration remain; potential solutions include robust validation, regulatory oversight, and "human-AI teaming" strategies to ensure safe, effective deployment. We remain optimistic in the potential of genAI to augment clinical expertise due to the adaptability of genAI to handle multiple data modalities to obtain and focus relevant information flows and the human-friendly interfaces that facilitate ease of use. We believe that the potential of genAI for dynamic human-algorithmic interactions may allow for a degree of clinician-directed customization to enhance human presence.

Gastric cancer (GC) continues to pose a significant global health challenge, particularly in advanced stages where treatment options are severely constrained. Immunotherapy represents a groundbreaking advancement in cancer treatment, exhibiting promising therapeutic effects in patients diagnosed with gastric cancer. However, the efficacy of immunotherapy is not universally applicable to all individuals. Revealing precise biomarkers for tumor immunotherapy as targets or indicators for detection and evaluation can facilitate the resolution of this predicament. This study aims to identify serum tumor markers and blood cell ratios as predictive biomarkers to aid in the selection of gastric cancer patients who may benefit from PD-1 inhibitors therapy.

Subtotal laparoscopic cholecystectomy (LSC) is a rescue procedure in difficult case, retaining all advantages of minimally invasive surgery. The most reputed definition of subtotal cholecystectomy is the removal of 3/4th of gallbladder with closure of the infundibulum. The closure of the infundibulum can be with either intracorporeal interrupted suture or pre-knotted endo-loop. This study aims to share our experience with the stump closure techniques (either interrupted suture closure or endo-loop closure) during LSC so that the result of the study helps surgeons to choose an appropriate technique of the stump closure.

The higher prevalence of non-alcoholic fatty liver disease (NAFLD) in men than women before menopause and the reduced difference post-menopause suggest that sex hormones may influence liver lipid accumulation. This study compared the effects of sex hormones on lipid droplet (LD) accumulation in palmitate/ oleate-treated HepG2 cells.

Non-alcoholic fatty liver disease (NAFLD) is a global problem strongly interlinked with metabolic syndrome. Insulin resistance (IR) is a key factor both in pathogenesis and in the progression to liver fibrosis. This article highlights the frequency of IR in local population.

This study aimed to analyze the distribution characteristics of infecting microorganisms in the wound tissue of patients with perianal abscess and infection, as well as to identify factors affecting wound healing.

The purpose of this research is to evaluate the predictive capabilities of a radiomics model for the Ki67 index and its correlation with prognosis in advanced gastric tubular adenocarcinoma patients.

Non-alcoholic fatty liver disease is one of the most common chronic diseases all around the world, which significantly correlates with metabolic disorders and inflammatory cycles. Sarcopenia is a decrease in the mass of skeletal muscles interacting with factors such as inflammatory processes and chronic diseases. It can also lead to the aggravation of chronic diseases.

Hepatocellular carcinoma (HCC) has a poor prognosis, especially in elderly HCC patients. A growing number of studies have confirmed that nomogram based on demographic information, pathologic information, and treatment modalities are effective in predicting the prognosis of cancer patients. We aimed to develop an individualized and clinically useful nomogram for elderly patients.We also aimed to investigate the prognostic significance of different treatment modalities.

and aims: Although abdominal drainage tubes have been widely used to treat cholelithiasis, complications still affect patients' prognoses. There is no Standardized Nursing Process (SNP) for abdominal drainage tubes after Laparoscopic cholecystectomy (LC). This study aims to observe the clinical efficacy and explore the feasibility of SNP intervention for abdominal drainage tubes in cholelithiasis patients after LC.

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common chronic liver disease and represents a significant public health issue. Nevertheless, current risk stratification methods remain inadequate. The study aimed to use machine learning in the identification of significant features and the development of a predictive model to determine its usefulness in discrimination of MAFLD's risk stratification (low, moderate, and high) in adults.

Gastric cancer (GC) is one of the leading causes of cancer-related mortality worldwide, with limited therapeutic options and a poor prognosis, particularly in advanced stages. Glycometabolism, a hallmark of cancer, plays a critical role in tumor progression, immune evasion, and response to therapy. However, the specific roles of glycometabolism-related genes and their prognostic and therapeutic implications in GC remain inadequately understood.

Biliary disorders are a major health concern in Nigeria, where magnetic resonance cholangiopancreatography (MRCP), a non-invasive imaging tool offering effective duct visualization without radiation, is emerging as a key diagnostic modality. This retrospective study in Kano explored its role in diagnosing biliary and pancreatic disorders.