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203. Expert Consensus Framework for Standardizing Lung Ultrasound Training for Neonatologists Issued by ESPNIC Neonatal Critical Care Section and Point-of-Care Ultrasound Working Group.
作者: Yogen Singh.;Manuel Sanchez Luna.;Belinda Chan.;Almudena Alonso-Ojembarrena.;Nadya Yousef.;Mahmoud Montasser.;Virginie Meau-Petit.;Iuri Corsini.;Pradeep Suryawanshi.;Alok Sharma.;Anna Milan.;Lukas Aichhorn.;Simona Vladareanu.;Francesco Raimondi.;Daniele De Luca.
来源: Chest. 2026年
To provide an expert consensus framework for standardizing lung ultrasound training for neonatologists.
204. The Epidemiology of Cryptogenic Organizing Pneumonia: An Analysis of Data From the Nationwide Inpatient Sample.
Cryptogenic organizing pneumonia (COP) is a rare form of interstitial lung disease with limited epidemiologic data. Large epidemiologic studies for COP, to our knowledge, do not exist; this hinders a broader understanding of its incidence, demographic distribution, and hospital outcomes.
206. Association of Sleep-Related Hypoxemia With Survival in Patients With Non-Small Cell Lung Cancer: The NEOSAS Groupe Français de Pneumo-Cancérologie Study Group.
作者: Grégoire Justeau.;Laurent Greillier.;Florent Vinas.;Lionel Falchero.;Olivier Bylicki.;Marie Bernardi.;Francis Martin.;Isabelle Simon.;Didier Debieuvre.;Chrystèle Locher.;Acya Bizieux-Thaminy.;Virginie Levrat.;Stéphanie Fry.;Camille Guguen.;Frédéric Goutorbe.;Philippe Masson.;Franck Soyez.;Christos Chouaid.;Patrick Saulnier.;Frédéric Gagnadoux.
来源: Chest. 2026年
OSA and its hypoxia-related consequences are associated with an increased lung cancer risk.
207. Effects of a Novel Dual Phosphodiesterase 3 and 4 Inhibitor TQC3721 in Patients With COPD in China (PACER-II): A Phase 2, Multicenter, Randomized, Double-Anonymized, Placebo-Controlled Trial.
作者: Li-Xiu He.;Ling Yang.;Zu-Ke Xiao.;Rong Qiu.;Fa-Ming Yu.;Li-Qin Wu.;Wei-Hua Zhang.;Xun-Chao Liu.;Ling-Feng Min.;Xiu-Qin Ma.;Jian-Zhong Jiang.;Bo Yuan.;Ran-Ran Dai.;Dong Liu.;Xiao-Hua Li.;Tao Wang.;Jie Cao.;Xiao-Bin Luo.;Xiao-Ju Liu.;Chao Chen.;Wei-Guo Li.;Ding Yu.;Zhu Luo.;Wei-Min Li.; .
来源: Chest. 2026年169卷6期1536-1550页
Dual phosphodiesterase (PDE) 3 and 4 inhibitors have emerged as a novel therapeutic strategy for COPD, but their applicability remains limited to specific treatment contexts. To our knowledge, TQC3721 is a novel inhaled dual PDE3 and PDE4 inhibitor with synergistic bronchodilator and antiinflammatory effects.
208. Real-World Use of Consumer Sleep Devices: A Rapid Review.
作者: Joshua Landvatter.;Jeanna T Ryan.;Christopher M Depner.;Kelly Baron.
来源: Chest. 2026年169卷4期1101-1110页
As awareness of sleep's role in health grows, consumer sleep technologies (CSTs) have gained wide use among both researchers and the public. These devices offer continuous, noninvasive sleep tracking in real-world environments. However, understanding their accuracy compared with that of polysomnography (PSG), the gold standard in sleep measurement, remains limited, particularly in free-living settings and clinical populations. Assessing CST performance and usability in these contexts is essential for guiding future adoption.
209. Prophylactic Hemostatic Treatment to Control Iatrogenic Bleeding During Endobronchial Biopsy (PROTECT Study): A Multicenter, Randomized, Single-Anonymized, Placebo-Controlled Study.
作者: Bei Li.;Li He.;Wei Wu.;Min Ji.;Wen Zhang.;Lina Wang.;Tanushree Kochar.;Fang Yue.;Aijun Zhang.;Yijun Ge.;Xiaoyan Jin.;Yan Zhang.;Hongying Ma.;Qunli Ding.;Fei Tang.;Chao Cao.
来源: Chest. 2026年
Iatrogenic bleeding related to endobronchial biopsy could be catastrophic and might lead to fatal outcomes. Although some guidelines and studies recommend the prophylactic use of hemostatic agents, there is still insufficient evidence from clinical studies.
210. The Minimal Important Difference in N-Terminal Pro-Brain Natriuretic Peptide in Pulmonary Hypertension.
作者: Matthew R Lammi.;Sarah L Khan.;Youlan Rao.;Wei Zhao.;Aparna Balasubramanian.;Stephen C Mathai.
来源: Chest. 2026年
N-terminal pro-brain natriuretic peptide (NT-proBNP) is a commonly used biomarker of right-sided heart function in patients with pulmonary hypertension.
211. Antimicrobial Treatment of Mild Mycobacterium avium Complex Pulmonary Disease Predicted to Increase Survival and Quality-Adjusted Life Years: A Microsimulation Decision Analysis Model.
作者: Omri A Arbiv.;Gemma Postill.;Yunjoo Im.;Byung Woo Jhun.;Petros Pechlivanoglou.;Sarah K Brode.;Ahmed M Bayoumi.;Theodore K Marras.
来源: Chest. 2026年
Mycobacterium avium complex pulmonary disease (MAC-PD) can lead to chronic lung disease, which can necessitate intensive antimicrobial therapy. In patients with mild MAC-PD, uncertainty exists regarding whether guideline-based antimicrobial treatment should be used as compared with watchful waiting.
212. Can Matrix Metalloproteinase 12 Improve the Differentiation of Idiopathic Pulmonary Fibrosis and Fibrotic Hypersensitivity Pneumonitis and Associates With Antigen Response Pathways?
作者: Sam B Konkol.;Yong Huang.;Shwu-Fan Ma.;Stephen M Humphries.;David A Lynch.;Tessy Paul.;Numaan Malik.;Emma Strickland.;Hannah Mannem.;Justin M Oldham.;Ayodeji Adegunsoye.;Chad A Newton.;Andrea Oh.;Fernando Martinez.;Anne I Sperling.;John S Kim.;Imre Noth.
来源: Chest. 2026年
Accurate diagnosis of interstitial lung disease remains challenging. Multidisciplinary discussion is the current gold standard; however, it is resource-intensive and relies on expert opinion. Biologically based markers of disease are needed.
213. OSA Is Associated With Enhanced Coronary Collateral Circulation and Reduced Myocardial Injury During Acute Coronary Syndromes.
作者: Krish Dodani.;Albina Aldomà.;Adriano Targa.;Manuel Sánchez-de-la-Torre.;Alicia Sánchez-de-la-Torre.;Lucía Pinilla.;Jorge Abad.;Olga Mínguez.;Lydia Pascual.;Dolores Martínez.;Rafaela Vaca.;Ivan Juez-Garcia.;Ferran Barbé.;Ivan Benitez.
来源: Chest. 2026年
Some evidence suggests that OSA may attenuate myocardial injury and reduce infarct severity during acute coronary syndromes (ACSs), potentially through stimulation of coronary collateral circulation (CCC). However, the relationship between OSA and collateral development, and their combined impact on ACS event severity, remains unclear.
214. Clinical Sampling Challenges in Diagnosing Severe Respiratory Viral Infections.
作者: Antonio Piralla.;Cristina Russo.;Stefania Ranno.;Carla Acciarri.;Stefano Menzo.;Sara Uceda Renteria.;Annapaola Callegaro.;Maria Vittoria Francescon.;Elisa Vian.;Elisa Masi.;Elisabetta Pagani.;Giulia Piccirilli.;Tiziana Lazzarotto.;Alessandra Pierangeli.;Guido Antonelli.;Federica Novazzi.;Nicasio Mancini.;Fausto Baldanti.;Elena Pariani.; .
来源: Chest. 2026年
Respiratory viruses are a primary cause of pneumonia in both children and adults, particularly in cases of severe acute respiratory infection (SARI) requiring hospitalization. Although molecular diagnostic technologies have clearly enhanced detection capacity, the selection process of the sampling site substantially influences diagnostic accuracy.
215. Clinical Effectiveness and Cost-Effectiveness of Pulmonary Rehabilitation for People in Uganda With Post-TB Lung Disease: A Randomized Controlled Trial.
作者: Winceslaus Katagira.;Mark W Orme.;Richard Kasiita.;Jesse A Matheson.;Matthew Richardson.;Andy Barton.;Jalia Nanyonga.;Michael C Steiner.;Bruce Kirenga.;Sally J Singh.
来源: Chest. 2026年
Post-TB lung disease (PTLD) causes significant disability in survivors of TB. Pulmonary rehabilitation (PR) may offer effective disease management but lacks high-quality evidence in this underrepresented population.
216. Win Ratio Analysis to Clarify Clinical Benefits: A Post Hoc Analysis of Phase 3 BOREAS and NOTUS (Two Pivotal Studies to Assess the Efficacy, Safety, and Tolerability of Dupilumab in Patients With Moderate-to-Severe COPD With Type 2 Inflammation).
作者: Sanjay Ramakrishnan.;Nayia Petousi.;Jessica Bon.;Ian D Pavord.;Surya P Bhatt.;Klaus F Rabe.;Wenying Deng.;Changming Xia.;Jigna Heble.;Mena Soliman.;Simon Couillard.
来源: Chest. 2026年
Clinical trials often assess multiple end points; however, many do not consider the value of composite end points. Although some evaluations of composite end points consider each outcome to be of equal importance, win ratio analysis ranks outcomes by clinical severity, prioritizing more serious events that have the biggest impact on patients.
217. Evaluating the Association Between Patient Priorities and ICU Care Delivery in Adults Receiving Mechanical Ventilation.
作者: Kara A Donovan.;Madison Polley.;Geralyn Palmer.;Bret M Hanlon.;Lily N Stalter.;Helen K Donnelly.;Richard G Wunderink.;Catherine A Gao.;Jacqueline M Kruser.; .
来源: Chest. 2026年169卷6期1551-1560页
Understanding how ICU treatments align with a patient's priorities is crucial to evaluating and improving critical care. Measuring this alignment is challenging, however, because patient priorities evolve over time and are not systematically documented in electronic health records (EHRs).
218. Association of High Cardiovascular Disease Risk OSA With Incident Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis.
作者: Jing Xu.;Younghoon Kwon.;Neda Esmaeili.;Scott A Sands.;Mohammadreza Hajipour.;Daniel Vena.;Susan R Heckbert.;Elsayed Z Soliman.;Andrew Wellman.;Erin D Michos.;Daniel J Gottlieb.;Susan Redline.;Ali Azarbarzin.
来源: Chest. 2026年
OSA is associated with atrial fibrillation (AF), but this association varies by population and definitions of OSA and AF.
219. Demographic and Physiological Differences Between Fibrotic and Nonfibrotic CT Subtypes of Sarcoidosis.
作者: Ruchi Yadav.;Wren L Lippitt.;Kum Ju Chae.;Jared Rieck.;Nichole E Carlson.;Shu-Yi Liao.;Margaret M Mroz.;Briana Barkes.;Stephen M Humphries.;Andrea Oh.;Hye Jeon Hwang.;Katherine Parker.;Andrea I Fuentealba.;Thomas McLaren.;Cristina Marrocchio.;Tasha E Fingerlin.;Daniel A Culver.;David A Lynch.;Lisa A Maier.
来源: Chest. 2026年
One approach to categorizing patients using chest CT imaging manifestations of pulmonary sarcoidosis is to use 3 classifications: fibrotic, nonfibrotic, or no parenchymal abnormality. This study aimed to evaluate the relationships between these imaging subtypes and demographic and physiological variables in a large group of patients with sarcoidosis with chest CT imaging.
220. Understanding Pulmonary Fibrosis in Pediatric Interstitial Lung Disease: A Comprehensive Analysis.
作者: Handan Kekec.;Ayse Tana Aslan.;Ismail Akdulum.;Tugba Sismanlar Eyuboglu.;Ozge Ulgen.;Yasemin Mocan.;Sinem Can Oksay.;Deniz Dogru.;Ugur Ozcelık.;Meltem Akgul Erdal.;Figen Gulen.;Bahar Girgin Dindar.;Ece Ocak.;Fatma Nur Ayman.;Bahar Ece Tokdemir.;Gökçen Unal.;Fazılcan Zirek.;Esin Gizem Olgun.;Merve Nur Tekin.;Aysen Bingol.;Abdurrahman Erdem Basaran.;Betül Bankoglu Parlak.;Bülent Karadağ.;Merve Selcuk Balcı.;Almala Pınar Ergenekon.;Mehmet Kose.;Ali Ersoy.;Celebi Yıldırım.;Goksen Dilşa Tugcu.;Beste Ozsezen.;Zeynep Seda Uyan.;Ayşe Kalyoncu Ucar.;Tuğba Ramaslı Gursoy.;Mahir Serbes.;Sedat Oktem.;Pelin Asfuroglu.;Melih Hangul.;Halime Nayır Buyuksahın.;Mina Hızal.;Gokcen Kartal Ozturk.;Ayşe Ayzıt Kılınc Sakallı.;Ebru Yalcın.;Saniye Girit.;Sevgi Pekcan.;Nagehan Emiralioglu.;Nazan Cobanoglu.;Güzin Cinel.;Yasemin Gökdemir.;Diclehan Orhan.;Ahmet Cevdet Ceylan.;Berna Oguz.;Nural Kiper.
来源: Chest. 2026年
Childhood interstitial lung diseases (chILDs) encompass a wide range of rare, chronic respiratory disorders, with pulmonary fibrosis (PF) being the clinical entity closely associated with mortality and morbidity.
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